RWD2B_MOUSE
ID RWD2B_MOUSE Reviewed; 290 AA.
AC Q99M03; Q9JLH4;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=RWD domain-containing protein 2B;
GN Name=Rwdd2b; Synonyms=ORF5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=10729227; DOI=10.1006/geno.1999.6109;
RA Orti R., Rachidi M., Vialard F., Toyama K., Lopes C., Taudien S.,
RA Rosenthal A., Yaspo M.-L., Sinet P.-M., Delabar J.-M.;
RT "Characterization of a novel gene, C21orf6, mapping to a critical region of
RT chromosome 21q22.1 involved in the monosomy 21 phenotype and of its murine
RT ortholog, orf5.";
RL Genomics 64:203-210(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AF177771; AAF63681.1; -; mRNA.
DR EMBL; AK084966; BAC39322.1; -; mRNA.
DR EMBL; BC002143; AAH02143.1; -; mRNA.
DR CCDS; CCDS37383.1; -.
DR RefSeq; NP_058620.2; NM_016924.2.
DR AlphaFoldDB; Q99M03; -.
DR SMR; Q99M03; -.
DR STRING; 10090.ENSMUSP00000049168; -.
DR iPTMnet; Q99M03; -.
DR PhosphoSitePlus; Q99M03; -.
DR EPD; Q99M03; -.
DR jPOST; Q99M03; -.
DR MaxQB; Q99M03; -.
DR PaxDb; Q99M03; -.
DR PRIDE; Q99M03; -.
DR ProteomicsDB; 255427; -.
DR Antibodypedia; 6351; 12 antibodies from 9 providers.
DR DNASU; 53858; -.
DR Ensembl; ENSMUST00000039101; ENSMUSP00000049168; ENSMUSG00000041079.
DR GeneID; 53858; -.
DR KEGG; mmu:53858; -.
DR UCSC; uc007zui.1; mouse.
DR CTD; 10069; -.
DR MGI; MGI:1858215; Rwdd2b.
DR VEuPathDB; HostDB:ENSMUSG00000041079; -.
DR eggNOG; ENOG502QR2G; Eukaryota.
DR GeneTree; ENSGT00390000007224; -.
DR HOGENOM; CLU_046295_1_0_1; -.
DR InParanoid; Q99M03; -.
DR OMA; SMFPYEE; -.
DR OrthoDB; 1387276at2759; -.
DR PhylomeDB; Q99M03; -.
DR TreeFam; TF324344; -.
DR BioGRID-ORCS; 53858; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Rwdd2b; mouse.
DR PRO; PR:Q99M03; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q99M03; protein.
DR Bgee; ENSMUSG00000041079; Expressed in ear vesicle and 244 other tissues.
DR Genevisible; Q99M03; MM.
DR Gene3D; 3.10.110.10; -; 1.
DR InterPro; IPR010541; Prp3_C.
DR InterPro; IPR006575; RWD-domain.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR InterPro; IPR017359; UCP038021_RWD.
DR PANTHER; PTHR15955; PTHR15955; 1.
DR Pfam; PF06544; DUF1115; 1.
DR Pfam; PF05773; RWD; 1.
DR PIRSF; PIRSF038021; UCP038021_RWDD2; 1.
DR SMART; SM00591; RWD; 1.
DR SUPFAM; SSF54495; SSF54495; 1.
DR PROSITE; PS50908; RWD; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..290
FT /note="RWD domain-containing protein 2B"
FT /id="PRO_0000079505"
FT DOMAIN 12..136
FT /note="RWD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00179"
FT CONFLICT 35..37
FT /note="LAE -> FGTR (in Ref. 1; AAF63681)"
FT /evidence="ECO:0000305"
FT CONFLICT 220
FT /note="K -> E (in Ref. 1; AAF63681)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 290 AA; 32892 MW; 85ACC401AA03ACDE CRC64;
MVEMEQAEAQ LSELDLLASM FPSENELIVN DQLALAELKD CIEKRTMEGR SSQVYFTINV
SLDLSEAAVV TFSLSCILPF KYPTVLPEIT VRSVSLSRSQ QTQLNTDLIA YLQKNCLGDV
CILNATEWVK EHAFDYVNIE ALPSPARQST AQPEDLAFTR LWIYSHHIYN KCKRRNILEW
AKELSLTGFS MPGKPGVVCV EGPQSACEEF WSRLRKLNWK RILIRHREDI PLDGTAGGME
GQRKFPILEE KAFSVHGARG NHMDFGQLYQ FLNARGCGDV FQMFFGVEGQ
