RWDD1_MOUSE
ID RWDD1_MOUSE Reviewed; 243 AA.
AC Q9CQK7;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=RWD domain-containing protein 1;
DE AltName: Full=DRG family-regulatory protein 2;
DE AltName: Full=IH1;
GN Name=Rwdd1; Synonyms=Dfrp2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Thymus;
RA Li C., Li Y., He W.;
RT "A novel gene associated with murine thymus atrophy.";
RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Limb;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP INTERACTION WITH DRG2, AND FUNCTION.
RX PubMed=15676025; DOI=10.1111/j.1365-2443.2005.00825.x;
RA Ishikawa K., Azuma S., Ikawa S., Semba K., Inoue J.;
RT "Identification of DRG family regulatory proteins (DFRPs): specific
RT regulation of DRG1 and DRG2.";
RL Genes Cells 10:139-150(2005).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Protects DRG2 from proteolytic degradation.
CC {ECO:0000269|PubMed:15676025}.
CC -!- SUBUNIT: Interacts with androgen receptor (By similarity). Interacts
CC with DRG2. {ECO:0000250, ECO:0000269|PubMed:15676025}.
CC -!- SIMILARITY: Belongs to the RWDD1/GIR2 family. {ECO:0000305}.
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DR EMBL; AF503942; AAM27457.1; -; mRNA.
DR EMBL; AK003262; BAB22678.2; ALT_SEQ; mRNA.
DR EMBL; AK005278; BAB23927.1; -; mRNA.
DR EMBL; AK011277; BAB27511.1; -; mRNA.
DR EMBL; BC062136; AAH62136.1; -; mRNA.
DR CCDS; CCDS23773.1; -.
DR RefSeq; NP_079890.1; NM_025614.3.
DR AlphaFoldDB; Q9CQK7; -.
DR BMRB; Q9CQK7; -.
DR SMR; Q9CQK7; -.
DR BioGRID; 211532; 3.
DR IntAct; Q9CQK7; 1.
DR MINT; Q9CQK7; -.
DR STRING; 10090.ENSMUSP00000019917; -.
DR iPTMnet; Q9CQK7; -.
DR PhosphoSitePlus; Q9CQK7; -.
DR EPD; Q9CQK7; -.
DR MaxQB; Q9CQK7; -.
DR PaxDb; Q9CQK7; -.
DR PeptideAtlas; Q9CQK7; -.
DR PRIDE; Q9CQK7; -.
DR ProteomicsDB; 260960; -.
DR Antibodypedia; 32499; 124 antibodies from 24 providers.
DR DNASU; 66521; -.
DR Ensembl; ENSMUST00000019917; ENSMUSP00000019917; ENSMUSG00000019782.
DR GeneID; 66521; -.
DR KEGG; mmu:66521; -.
DR UCSC; uc007eun.1; mouse.
DR CTD; 51389; -.
DR MGI; MGI:1913771; Rwdd1.
DR VEuPathDB; HostDB:ENSMUSG00000019782; -.
DR eggNOG; KOG4018; Eukaryota.
DR GeneTree; ENSGT00390000009168; -.
DR HOGENOM; CLU_084528_2_0_1; -.
DR InParanoid; Q9CQK7; -.
DR OMA; IYCGELE; -.
DR OrthoDB; 1269244at2759; -.
DR PhylomeDB; Q9CQK7; -.
DR TreeFam; TF313662; -.
DR BioGRID-ORCS; 66521; 5 hits in 72 CRISPR screens.
DR ChiTaRS; Rwdd1; mouse.
DR PRO; PR:Q9CQK7; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q9CQK7; protein.
DR Bgee; ENSMUSG00000019782; Expressed in hindlimb stylopod muscle and 60 other tissues.
DR Genevisible; Q9CQK7; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:CAFA.
DR GO; GO:0005844; C:polysome; IBA:GO_Central.
DR GO; GO:0030521; P:androgen receptor signaling pathway; IMP:CAFA.
DR GO; GO:0034599; P:cellular response to oxidative stress; IDA:CAFA.
DR GO; GO:0071394; P:cellular response to testosterone stimulus; IMP:CAFA.
DR GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR GO; GO:2000825; P:positive regulation of androgen receptor activity; IMP:CAFA.
DR DisProt; DP00587; -.
DR Gene3D; 3.10.110.10; -; 1.
DR InterPro; IPR040213; GIR2-like.
DR InterPro; IPR006575; RWD-domain.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR InterPro; IPR032378; ZC3H15/TMA46_C.
DR PANTHER; PTHR12292; PTHR12292; 1.
DR Pfam; PF16543; DFRP_C; 1.
DR Pfam; PF05773; RWD; 1.
DR SMART; SM00591; RWD; 1.
DR SUPFAM; SSF54495; SSF54495; 1.
DR PROSITE; PS50908; RWD; 1.
PE 1: Evidence at protein level;
KW Acetylation; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9H446"
FT CHAIN 2..243
FT /note="RWD domain-containing protein 1"
FT /id="PRO_0000097541"
FT DOMAIN 10..114
FT /note="RWD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00179"
FT REGION 142..197
FT /note="Interaction with DRG2"
FT /evidence="ECO:0000269|PubMed:15676025"
FT REGION 208..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..231
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylthreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9H446"
FT MOD_RES 144
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9H446"
SQ SEQUENCE 243 AA; 27785 MW; 7CF857F6CC055F65 CRC64;
MTDYGEEQRN ELEALESIYP DSFTVLSESP PSFTITVTSE AGENDETVQT TLKFTYSEKY
PDETPLYEIF SQENLEDNDV SDILKLLALQ AEENLGMVMI FTLVTAVQEK LNEIVDQIKT
RREEEKKQKE KEAEEAEKKL FHGTPVTIEN FLSWKAKFDA ELLEIKKKRM KEEEQAGKNK
LSGKQLFETD HNLDTSDIQF LEDAGNNVEV DESLFQEMDD LELEDGEDDP DYNPVAPGSD
SSD
