ID   RWDD1_RAT               Reviewed;         243 AA.
AC   Q99ND9;
DT   15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=RWD domain-containing protein 1;
DE   AltName: Full=Small androgen receptor-interacting protein;
GN   Name=Rwdd1; Synonyms=Sarip;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Rouleau N., Reeben M., Palvimo J.J., Janne O.A.;
RT   "A small novel protein interacts with androgen receptor.";
RL   Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Protects DRG2 from proteolytic degradation. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with DRG2 (By similarity). Interacts with androgen
CC       receptor. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RWDD1/GIR2 family. {ECO:0000305}.
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DR   EMBL; AJ132390; CAC24710.1; -; mRNA.
DR   RefSeq; NP_671487.1; NM_147146.2.
DR   AlphaFoldDB; Q99ND9; -.
DR   BMRB; Q99ND9; -.
DR   SMR; Q99ND9; -.
DR   STRING; 10116.ENSRNOP00000062656; -.
DR   jPOST; Q99ND9; -.
DR   PaxDb; Q99ND9; -.
DR   PRIDE; Q99ND9; -.
DR   Ensembl; ENSRNOT00000095504; ENSRNOP00000085613; ENSRNOG00000042916.
DR   GeneID; 259218; -.
DR   KEGG; rno:259218; -.
DR   UCSC; RGD:631337; rat.
DR   CTD; 51389; -.
DR   RGD; 631337; Rwdd1.
DR   eggNOG; KOG4018; Eukaryota.
DR   GeneTree; ENSGT00390000009168; -.
DR   HOGENOM; CLU_084528_2_0_1; -.
DR   InParanoid; Q99ND9; -.
DR   OMA; IYCGELE; -.
DR   OrthoDB; 1269244at2759; -.
DR   PhylomeDB; Q99ND9; -.
DR   PRO; PR:Q99ND9; -.
DR   Proteomes; UP000002494; Chromosome 20.
DR   Bgee; ENSRNOG00000042916; Expressed in pancreas and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005844; C:polysome; IBA:GO_Central.
DR   GO; GO:0030521; P:androgen receptor signaling pathway; ISO:RGD.
DR   GO; GO:0034599; P:cellular response to oxidative stress; ISO:RGD.
DR   GO; GO:0071394; P:cellular response to testosterone stimulus; ISO:RGD.
DR   GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR   GO; GO:2000825; P:positive regulation of androgen receptor activity; ISO:RGD.
DR   Gene3D; 3.10.110.10; -; 1.
DR   InterPro; IPR040213; GIR2-like.
DR   InterPro; IPR006575; RWD-domain.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   InterPro; IPR032378; ZC3H15/TMA46_C.
DR   PANTHER; PTHR12292; PTHR12292; 1.
DR   Pfam; PF16543; DFRP_C; 1.
DR   Pfam; PF05773; RWD; 1.
DR   SMART; SM00591; RWD; 1.
DR   SUPFAM; SSF54495; SSF54495; 1.
DR   PROSITE; PS50908; RWD; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H446"
FT   CHAIN           2..243
FT                   /note="RWD domain-containing protein 1"
FT                   /id="PRO_0000097542"
FT   DOMAIN          10..114
FT                   /note="RWD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00179"
FT   REGION          142..197
FT                   /note="Interaction with DRG2"
FT                   /evidence="ECO:0000250"
FT   REGION          208..243
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..231
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylthreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H446"
FT   MOD_RES         144
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H446"
SQ   SEQUENCE   243 AA;  27782 MW;  57EA63249E2B3813 CRC64;
     MTDYGEEQRN ELEALESIYP DSFTVLSENP PSFTITVTSE AGENDETVQT TLKFTYSEKY
     PDEAPLYEIF SQENLEDNDV SDILKLLALQ AEENLGMVMI FTLVTAVQEK LNEIVDQIKT
     RREEEKKQKE KEAEEAEKKL FHGTPVTIEN FLSWKAKFDA ELLEIKKKRM KEEEQAGKNK
     LSGKQLFETD HNLDTSDIQF LEDAGNNVEV DESLFQEMDD LELEDGEDDP DYNPVAPGSD
     SSD