ID   RX1_ASTFA               Reviewed;         334 AA.
AC   Q9I9D5;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Retinal homeobox protein Rx1;
GN   Name=rx1;
OS   Astyanax fasciatus (Blind cave fish) (Astyanax mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Psalidodon.
OX   NCBI_TaxID=223369;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12068949;
RA   Strickler A.G., Famuditimi K., Jeffery W.R.;
RT   "Retinal homeobox genes and the role of cell proliferation in cavefish eye
RT   degeneration.";
RL   Int. J. Dev. Biol. 46:285-294(2002).
CC   -!- FUNCTION: Plays a critical role in eye formation by regulating the
CC       initial specification of retinal cells and/or their subsequent
CC       proliferation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC       ECO:0000255|PROSITE-ProRule:PRU00138}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF264703; AAF72201.1; -; mRNA.
DR   AlphaFoldDB; Q9I9D5; -.
DR   SMR; Q9I9D5; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR003654; OAR_dom.
DR   InterPro; IPR043562; RAX/RAX2.
DR   PANTHER; PTHR46271; PTHR46271; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03826; OAR; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS50803; OAR; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..334
FT                   /note="Retinal homeobox protein Rx1"
FT                   /id="PRO_0000049282"
FT   DNA_BIND        142..201
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          76..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          118..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           37..44
FT                   /note="Octapeptide motif"
FT   MOTIF           311..324
FT                   /note="OAR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT   MOTIF           317..321
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        118..142
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   334 AA;  37547 MW;  4D86BDADFD0652DE CRC64;
     MHLSLDTMNM VDDSCLSPGN FPEMVKGGMA AIGNRVHSID VILGFTKDQG PTLLNPGANT
     LTVPQKVEVE SLGQLGKQDH PTHPYGQLPL RDSSEQPAFH GTLDTEIFSN KCESELGEVR
     KVSDSDRKSP EQGDEEQPKK KHRRNRTTFT TYQLHELERA FEKSHYPDVY SREELAMKVN
     LPEVRVQVWF QNRRAKWRRQ EKMDASAVKL HDSPMLSFNR PPMHTNVGPM SNSLPLDPWL
     TSPLTSTTPV HSIPGFMGPS QGLQAGYPGH GFLNTPQSMG QSMQPMAPPP YQCPAVFTDK
     YPLEDTNQRS SSIASLRMKA KEHIQSMDKT WQPM