ID   RX1_CHICK               Reviewed;         228 AA.
AC   Q9PVY0; Q547X8;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=Retinal homeobox protein Rx1;
DE            Short=cRax1;
GN   Name=RX1; Synonyms=RAX1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10415362; DOI=10.1016/s0925-4773(99)00094-5;
RA   Ohuchi H., Tomonari S., Itoh H., Mikawa T., Noji S.;
RT   "Identification of chick rax/rx genes with overlapping patterns of
RT   expression during early eye and brain development.";
RL   Mech. Dev. 85:193-195(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12403708; DOI=10.1242/dev.00114;
RA   Chen C.-M.A., Cepko C.L.;
RT   "The chicken RaxL gene plays a role in the initiation of photoreceptor
RT   differentiation.";
RL   Development 129:5363-5375(2002).
CC   -!- FUNCTION: Plays a critical role in eye formation by regulating the
CC       initial specification of retinal cells and/or their subsequent
CC       proliferation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC       ECO:0000255|PROSITE-ProRule:PRU00138}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AB015750; BAA84748.1; -; mRNA.
DR   EMBL; AF420601; AAN32719.1; -; mRNA.
DR   RefSeq; NP_989435.2; NM_204104.2.
DR   AlphaFoldDB; Q9PVY0; -.
DR   SMR; Q9PVY0; -.
DR   STRING; 9031.ENSGALP00000031663; -.
DR   PaxDb; Q9PVY0; -.
DR   Ensembl; ENSGALT00000032299; ENSGALP00000031663; ENSGALG00000013431.
DR   GeneID; 373893; -.
DR   KEGG; gga:373893; -.
DR   CTD; 84839; -.
DR   VEuPathDB; HostDB:geneid_373893; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   GeneTree; ENSGT00940000163917; -.
DR   HOGENOM; CLU_047013_2_0_1; -.
DR   InParanoid; Q9PVY0; -.
DR   OMA; MTANVGP; -.
DR   OrthoDB; 1085093at2759; -.
DR   PhylomeDB; Q9PVY0; -.
DR   PRO; PR:Q9PVY0; -.
DR   Proteomes; UP000000539; Chromosome 28.
DR   Bgee; ENSGALG00000013431; Expressed in granulocyte and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR003654; OAR_dom.
DR   InterPro; IPR043562; RAX/RAX2.
DR   PANTHER; PTHR46271; PTHR46271; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03826; OAR; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS50803; OAR; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..228
FT                   /note="Retinal homeobox protein Rx1"
FT                   /id="PRO_0000049280"
FT   DNA_BIND        36..95
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           205..218
FT                   /note="OAR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT   MOTIF           211..215
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   228 AA;  25844 MW;  ACFBEA26CB34980E CRC64;
     MFLNKCEGDL GELRKPGDSE GTPPAAAEEE QPKKKHRRNR TTFTTYQLHE LERAFEKSHY
     PDVYSREELA MKVNLPEVRV QVWFQNRRAK WRRQEKMEAS SMKLHDTPML SFNRPPMTAN
     VGPMSNSLPL DPWLTSPISS ATPVHSIPGF MGAPQALQPP YGGHSFLNTP PGMAQGMQPM
     APAPYQCGTP FVDKYPLEDV DQRSSSIASL RMKAKEHIQT IDKTWQPI