ID   RX1_DANRE               Reviewed;         330 AA.
AC   O42356;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 2.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Retinal homeobox protein Rx1;
GN   Name=rx1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11180949; DOI=10.1006/dbio.2000.0125;
RA   Chuang J.C., Raymond P.A.;
RT   "Zebrafish genes rx1 and rx2 help define the region of forebrain that gives
RT   rise to retina.";
RL   Dev. Biol. 231:13-30(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 129-330.
RC   TISSUE=Embryo;
RX   PubMed=9177348; DOI=10.1038/42475;
RA   Mathers P.H., Grinberg A., Mahon K.A., Jamrich M.;
RT   "The Rx homeobox gene is essential for vertebrate eye development.";
RL   Nature 387:603-607(1997).
CC   -!- FUNCTION: Plays a critical role in eye formation by regulating the
CC       initial specification of retinal cells and/or their subsequent
CC       proliferation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC       ECO:0000255|PROSITE-ProRule:PRU00138}.
CC   -!- TISSUE SPECIFICITY: Expressed in the outer nuclear layer, in cone
CC       photoreceptor.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the optic primordia and in cone
CC       photoreceptors of the differentiated neural retina.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF001907; AAB62325.2; -; mRNA.
DR   AlphaFoldDB; O42356; -.
DR   SMR; O42356; -.
DR   STRING; 7955.ENSDARP00000096944; -.
DR   PaxDb; O42356; -.
DR   ZFIN; ZDB-GENE-990415-236; rx1.
DR   eggNOG; KOG0490; Eukaryota.
DR   InParanoid; O42356; -.
DR   PRO; PR:O42356; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0060219; P:camera-type eye photoreceptor cell differentiation; IMP:ZFIN.
DR   GO; GO:0003407; P:neural retina development; IMP:ZFIN.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0010842; P:retina layer formation; IMP:ZFIN.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR003654; OAR_dom.
DR   InterPro; IPR043562; RAX/RAX2.
DR   PANTHER; PTHR46271; PTHR46271; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03826; OAR; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS50803; OAR; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..330
FT                   /note="Retinal homeobox protein Rx1"
FT                   /id="PRO_0000049283"
FT   DNA_BIND        137..196
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          66..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          118..142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           37..44
FT                   /note="Octapeptide motif"
FT   MOTIF           306..319
FT                   /note="OAR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT   MOTIF           312..316
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        118..136
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   330 AA;  36936 MW;  15F8658CA97EC248 CRC64;
     MHLSLDTMNM VDDSCLSPSN FHDMVKAGGA VVGTRVHSID VILGFNKDQD SLLNPGDNAV
     AHKVGGESLG EPGKLDQRVQ PYGHLPPLRD GSEQPTFHDA DMFSNKCDGD LGDLRKAIES
     DSKSPDSADG EQPKKKHRRN RTTFTTYQLH ELERAFEKSH YPDVYSREEL AMKVNLPEVR
     VQVWFQNRRA KWRRQEKIDA STMKLHDSPM LSFNRPSMHP TVGPMNNSLP LDPWLPSPLS
     SATPVHSIPG FMGPTQGLQT GYPGHSFLSP PQPMAQSMQP MAPPPYQCPP PFTDKYPLED
     VDQRSSSIAA LRMKAKEHIQ SMDKTWQPMC