ID   RX2_CHICK               Reviewed;         317 AA.
AC   Q9PVX0;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Retinal homeobox protein Rx2;
DE            Short=cRax2;
GN   Name=RX2; Synonyms=RAX2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10415362; DOI=10.1016/s0925-4773(99)00094-5;
RA   Ohuchi H., Tomonari S., Itoh H., Mikawa T., Noji S.;
RT   "Identification of chick rax/rx genes with overlapping patterns of
RT   expression during early eye and brain development.";
RL   Mech. Dev. 85:193-195(1999).
CC   -!- FUNCTION: Plays a critical role in eye formation by regulating the
CC       initial specification of retinal cells and/or their subsequent
CC       proliferation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC       ECO:0000255|PROSITE-ProRule:PRU00138}.
CC   -!- DEVELOPMENTAL STAGE: Expressed at stage 4 in the ectoderm, at stage 6
CC       in the anterior most neural plate, at stage 7 and 8 in the anterior
CC       neural fold and at stage 9-10 in the evaginating optic vesicles. At
CC       stage 14, highly expressed in developing retina and in infundibulum
CC       region.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AB020318; BAA84749.1; -; mRNA.
DR   AlphaFoldDB; Q9PVX0; -.
DR   STRING; 9031.ENSGALP00000040726; -.
DR   VEuPathDB; HostDB:geneid_100677794; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   InParanoid; Q9PVX0; -.
DR   PhylomeDB; Q9PVX0; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR003654; OAR_dom.
DR   InterPro; IPR043562; RAX/RAX2.
DR   PANTHER; PTHR46271; PTHR46271; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03826; OAR; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS50803; OAR; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..317
FT                   /note="Retinal homeobox protein Rx2"
FT                   /id="PRO_0000049281"
FT   DNA_BIND        122..181
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          44..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           33..40
FT                   /note="Octapeptide motif"
FT   MOTIF           294..307
FT                   /note="OAR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT   MOTIF           300..304
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        108..122
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   317 AA;  34057 MW;  10DDF1BEC9A24910 CRC64;
     MHPPGAPFAM AEGAFSLSAP AARSPGGNPS RLHSIEAILG FTKDDGLLGP FQPDGGAGSA
     KEAADKRGPR HCLPKGPAEP PPAEHQGRFQ EPYCPGSASP ELPAGDGGDG KPSDEEQPKK
     KHRRNRTTFT TYQLHELERA FEKSHYPDVY SREELAMKVN LPEVRVQVWF QNRRAKWRRQ
     EKLEVSSMKL QDSPILSFSR SPQAAPVGAL GGSLPLETWL GPPVPGGAAL QSLPGFAAPP
     QGLPASYTPP PFLNSPAVTH ALQPLGAMGP PPPYQCGAAF VDKFPLDEGD PRNTSIASLR
     MKAKEHIQSI GKPWQTI