ID   RX2_DANRE               Reviewed;         327 AA.
AC   O42357;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Retinal homeobox protein Rx2;
GN   Name=rx2;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo;
RX   PubMed=9177348; DOI=10.1038/42475;
RA   Mathers P.H., Grinberg A., Mahon K.A., Jamrich M.;
RT   "The Rx homeobox gene is essential for vertebrate eye development.";
RL   Nature 387:603-607(1997).
CC   -!- FUNCTION: Plays a critical role in eye formation by regulating the
CC       initial specification of retinal cells and/or their subsequent
CC       proliferation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC       ECO:0000255|PROSITE-ProRule:PRU00138}.
CC   -!- TISSUE SPECIFICITY: Expressed in the outer nuclear layer, in cone
CC       photoreceptor.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the developing retina.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF001908; AAB62326.1; -; mRNA.
DR   AlphaFoldDB; O42357; -.
DR   SMR; O42357; -.
DR   STRING; 7955.ENSDARP00000105437; -.
DR   PaxDb; O42357; -.
DR   ZFIN; ZDB-GENE-990415-237; rx2.
DR   eggNOG; KOG0490; Eukaryota.
DR   InParanoid; O42357; -.
DR   PhylomeDB; O42357; -.
DR   PRO; PR:O42357; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0060219; P:camera-type eye photoreceptor cell differentiation; IGI:ZFIN.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR003654; OAR_dom.
DR   InterPro; IPR043562; RAX/RAX2.
DR   PANTHER; PTHR46271; PTHR46271; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03826; OAR; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS50803; OAR; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..327
FT                   /note="Retinal homeobox protein Rx2"
FT                   /id="PRO_0000049284"
FT   DNA_BIND        135..194
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          48..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          100..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           37..44
FT                   /note="Octapeptide motif"
FT   MOTIF           304..317
FT                   /note="OAR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT   MOTIF           310..314
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        52..73
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        106..135
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   327 AA;  37153 MW;  A55EFF31888297BA CRC64;
     MHLSPDTMNM VDDGCLSTES YHDLGKGGVS GISGRVHSID VILGFSKDQD PLLEPSGRHK
     VDEDQLEEQE KQVNADPYSH LQIPDQTQQQ QSVYHDTGLF STDKCDADLG DPRSNVESDS
     RSPDIPDEDQ PKKKHRRNRT TFTTYQLHEL ERAFEKSHYP DVYSREELAM KVNLPEVRVQ
     VWFQNRRAKW RRQEKMDTGT MKLHDSPIRS FNRPPMAPNV GPMSNSLPLD PWLSSPLSSA
     TPMHSIPGFM GPGQSLQPTY TAHPGFLNTS PGMMQNIQPM PPPPYQCQPV FNDKYPLEDV
     DRSSSIAALR MKAKEHIQSM DKTWQPM