ID   RX3_DANRE               Reviewed;         292 AA.
AC   O42358;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Retinal homeobox protein Rx3;
GN   Name=rx3;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo;
RX   PubMed=9177348; DOI=10.1038/42475;
RA   Mathers P.H., Grinberg A., Mahon K.A., Jamrich M.;
RT   "The Rx homeobox gene is essential for vertebrate eye development.";
RL   Nature 387:603-607(1997).
CC   -!- FUNCTION: Plays a critical role in eye formation by regulating the
CC       initial specification of retinal cells and/or their subsequent
CC       proliferation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC       ECO:0000255|PROSITE-ProRule:PRU00138}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the ventral forebrain.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF001909; AAB62327.1; -; mRNA.
DR   RefSeq; NP_571302.1; NM_131227.1.
DR   AlphaFoldDB; O42358; -.
DR   SMR; O42358; -.
DR   STRING; 7955.ENSDARP00000069319; -.
DR   PaxDb; O42358; -.
DR   GeneID; 30474; -.
DR   KEGG; dre:30474; -.
DR   CTD; 30474; -.
DR   ZFIN; ZDB-GENE-990415-238; rx3.
DR   eggNOG; KOG0490; Eukaryota.
DR   InParanoid; O42358; -.
DR   OrthoDB; 1085093at2759; -.
DR   PhylomeDB; O42358; -.
DR   PRO; PR:O42358; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0021984; P:adenohypophysis development; IMP:ZFIN.
DR   GO; GO:0048593; P:camera-type eye morphogenesis; IMP:ZFIN.
DR   GO; GO:0001708; P:cell fate specification; IMP:ZFIN.
DR   GO; GO:0048596; P:embryonic camera-type eye morphogenesis; IMP:ZFIN.
DR   GO; GO:0001654; P:eye development; IMP:ZFIN.
DR   GO; GO:0060898; P:eye field cell fate commitment involved in camera-type eye formation; IMP:ZFIN.
DR   GO; GO:0030900; P:forebrain development; IMP:ZFIN.
DR   GO; GO:0021854; P:hypothalamus development; IMP:ZFIN.
DR   GO; GO:0001755; P:neural crest cell migration; IMP:ZFIN.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0060041; P:retina development in camera-type eye; IMP:ZFIN.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR003654; OAR_dom.
DR   InterPro; IPR043562; RAX/RAX2.
DR   PANTHER; PTHR46271; PTHR46271; 2.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03826; OAR; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS50803; OAR; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..292
FT                   /note="Retinal homeobox protein Rx3"
FT                   /id="PRO_0000049285"
FT   DNA_BIND        106..165
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          53..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          85..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           32..39
FT                   /note="Octapeptide motif"
FT   MOTIF           272..285
FT                   /note="OAR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT   MOTIF           278..282
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..17
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        92..106
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   292 AA;  32757 MW;  391892B067AA7A96 CRC64;
     MRLVGSQYKD MEDRLSPSAR LVRSPGSQTR IHSIESILGF KGETLFHPAF PYGSGKTGKD
     TEHLSPKKDS NKHFDGVCRS TVMVSPDLPD ADGGKLSDDE NPKKKHRRNR TTFTTFQLHE
     LERAFEKSHY PDVYSREELA LKVNLPEVRV QVWFQNRRAK WRRQEKLEVS SIKLQESSML
     SIPRSGPLSL GSGLPLEPWL TGPISTSSSP LQSLPSFITP QQAVPASYTP PQFLSSSTLN
     HSLPHIGAVC PPYQCSGFMD KFSLQEADPR NTSIASLRMK AKEHIQSIGK TW