ID   RXB_XENLA               Reviewed;         325 AA.
AC   O42567; Q0IHH4;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   23-MAR-2010, sequence version 2.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Retinal homeobox protein Rx-B;
DE   AltName: Full=Retina and anterior neural fold homeobox protein B;
DE   AltName: Full=Rx2A;
DE            Short=Xrx2;
GN   Name=rax-b; Synonyms=rx2, rx2a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Ectoderm;
RX   PubMed=9177348; DOI=10.1038/42475;
RA   Mathers P.H., Grinberg A., Mahon K.A., Jamrich M.;
RT   "The Rx homeobox gene is essential for vertebrate eye development.";
RL   Nature 387:603-607(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a critical role in eye formation by regulating the
CC       initial specification of retinal cells and/or their subsequent
CC       proliferation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC       ECO:0000255|PROSITE-ProRule:PRU00138}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in anterior neural plate followed
CC       by neural retina, pigmented epithelium, in pineal gland, diencephalon
CC       floor and epiphysis. At later stages, the neuroretina remains the
CC       primary site of expression. No expression in the developing lens and
CC       cornea. {ECO:0000269|PubMed:9177348}.
CC   -!- DEVELOPMENTAL STAGE: Expression begins in stage 11 (late-gastrula)
CC       embryos and then appears to be maintained at fairly stable levels up to
CC       stage 45 (late tadpole), when it declines.
CC       {ECO:0000269|PubMed:9177348}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-9 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; AF001049; AAB62323.1; -; mRNA.
DR   EMBL; BC123153; AAI23154.1; -; mRNA.
DR   RefSeq; NP_001081689.1; NM_001088220.1.
DR   AlphaFoldDB; O42567; -.
DR   SMR; O42567; -.
DR   DNASU; 397999; -.
DR   GeneID; 397999; -.
DR   KEGG; xla:397999; -.
DR   CTD; 397999; -.
DR   Xenbase; XB-GENE-866185; rax.L.
DR   OMA; AYRPEEC; -.
DR   OrthoDB; 1085093at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 397999; Expressed in camera-type eye and 2 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR003654; OAR_dom.
DR   InterPro; IPR043562; RAX/RAX2.
DR   PANTHER; PTHR46271; PTHR46271; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03826; OAR; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS50803; OAR; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..325
FT                   /note="Retinal homeobox protein Rx-B"
FT                   /id="PRO_0000049279"
FT   DNA_BIND        130..189
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          75..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           32..39
FT                   /note="Octapeptide motif"
FT   MOTIF           302..315
FT                   /note="OAR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT   MOTIF           308..312
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        95..119
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        288
FT                   /note="F -> Y (in Ref. 1; AAB62323)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   325 AA;  36314 MW;  8F9D4CCA840D3B1F CRC64;
     MHLHSPPLMA DGSFSLSGHL LRSPGGNPSR LHSIEAILGF AKEDSVLGSF QSEVSPRNAK
     EVDKRSSRHC LHKMTEEIHP QQEHLEDGQT GGYGDPYSAK TSSECLSPGL STSNSDNKLS
     DDEQQPKKKH RRNRTTFTTY QLHELERAFE KSHYPDVYSR EELAMKVNLP EVRVQVWFQN
     RRAKWRRQEK LEVTSMKLQD SPMLSFNRSP QPSAMSALSS SLPLDSWLTP PLSNSTALQS
     LPGFVTTPTS LPGSYTPPPF INPASMGHAL QPLGAMGPPP PYQCGANFVD KYPLEEIDPR
     NNSIASLRMK AKEHIQSFGK PWQTI