ID   RXLAB_PHYIT             Reviewed;         154 AA.
AC   P0CU90; D0NSE5;
DT   18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2019, sequence version 1.
DT   03-AUG-2022, entry version 10.
DE   RecName: Full=Secreted RxLR effector protein PITG_21681 {ECO:0000303|PubMed:31234322};
DE   Flags: Precursor;
GN   ORFNames=PITG_21681;
OS   Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=403677;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND INDUCTION.
RC   STRAIN=T30-4;
RX   PubMed=19741609; DOI=10.1038/nature08358;
RG   The Broad Institute Genome Sequencing Platform;
RA   Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA   Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA   Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA   Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA   Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA   Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA   Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA   Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA   Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA   Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA   Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA   Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA   Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA   Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA   Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA   Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA   Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA   Nusbaum C.;
RT   "Genome sequence and analysis of the Irish potato famine pathogen
RT   Phytophthora infestans.";
RL   Nature 461:393-398(2009).
RN   [2]
RP   INDUCTION, AND FUNCTION.
RX   PubMed=31234322; DOI=10.3390/ijms20123031;
RA   Wang J., Gao C., Li L., Cao W., Dong R., Ding X., Zhu C., Chu Z.;
RT   "Transgenic RXLR effector PITG_15718.2 suppresses immunity and reduces
RT   vegetative growth in potato.";
RL   Int. J. Mol. Sci. 20:0-0(2019).
CC   -!- FUNCTION: Secreted effector that is involved in host plant infection
CC       (By similarity). Increases the susceptibility to P.infestans and
CC       reduces the plant growth (By similarity). Affects the expression of
CC       host genes (By similarity). {ECO:0000250|UniProtKB:P0CU89}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0CU89}. Host
CC       cell {ECO:0000250|UniProtKB:P0CU89}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000250|UniProtKB:P0CU89}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; DS028863; EEY68897.1; -; Genomic_DNA.
DR   RefSeq; XP_002897993.1; XM_002897947.1.
DR   RefSeq; XP_002996886.1; XM_002996840.1.
DR   AlphaFoldDB; P0CU90; -.
DR   GeneID; 9473566; -.
DR   GeneID; 9475463; -.
DR   KEGG; pif:PITG_15718; -.
DR   KEGG; pif:PITG_21681; -.
DR   VEuPathDB; FungiDB:PITG_15718; -.
DR   VEuPathDB; FungiDB:PITG_21681; -.
DR   Proteomes; UP000006643; Partially assembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043657; C:host cell; IEA:UniProtKB-SubCell.
DR   InterPro; IPR031825; RXLR.
DR   Pfam; PF16810; RXLR; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Signal; Virulence.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..154
FT                   /note="Secreted RxLR effector protein PITG_21681"
FT                   /id="PRO_0000447985"
FT   REGION          42..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           53..72
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000250|UniProtKB:P0CU89"
SQ   SEQUENCE   154 AA;  17417 MW;  5BEF043B40E6F6F8 CRC64;
     MRRYAALMVI DAVLLSTSQA LSSSHASELR SQLSAADAMF PSAERDGGIP NKRSLRRISV
     TESNDGERDE ERGFQISILT KLQKWATKMK LPKTTKNLQF RIWPKEKKDP KAVYAELKLA
     GLDPKAAKAN PEFADYLAYS KIWNHRGGRY MTRS