ID   RXLAD_PHYIT             Reviewed;         229 AA.
AC   D0NNI8;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2009, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Secreted RxLR effector protein PITG_22926 {ECO:0000303|PubMed:19741609};
DE   Flags: Precursor;
GN   ORFNames=PITG_14054;
OS   Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=403677;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T30-4;
RX   PubMed=19741609; DOI=10.1038/nature08358;
RG   The Broad Institute Genome Sequencing Platform;
RA   Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA   Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA   Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA   Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA   Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA   Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA   Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA   Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA   Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA   Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA   Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA   Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA   Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA   Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA   Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA   Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA   Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA   Nusbaum C.;
RT   "Genome sequence and analysis of the Irish potato famine pathogen
RT   Phytophthora infestans.";
RL   Nature 461:393-398(2009).
RN   [2]
RP   FUNCTION, AND INDUCTION.
RX   DOI=10.1007/s10658-017-1222-9;
RA   Vetukuri R.R., Whisson S.C., Grenville-Briggs L.J.;
RT   "Phytophthora infestans effector Pi14054 is a novel candidate suppressor of
RT   host silencing mechanisms.";
RL   Eur. J. Plant Pathol. 149:771-777(2017).
CC   -!- FUNCTION: Secreted effector that acts as a RNA silencing suppressor,
CC       probably by inhibiting the biogenesis of small RNAs in the host plant,
CC       to manipulate host immune responses and promote Phytophthora infection.
CC       {ECO:0000269|Ref.2}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|Ref.2}. Host nucleus
CC       {ECO:0000305|Ref.2}.
CC   -!- INDUCTION: Expression is specifically induced early in the infection
CC       process, in contact with host tissue. {ECO:0000269|Ref.2}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:19741609}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; DS028149; EEY62159.1; -; Genomic_DNA.
DR   RefSeq; XP_002899190.1; XM_002899144.1.
DR   AlphaFoldDB; D0NNI8; -.
DR   SMR; D0NNI8; -.
DR   EnsemblProtists; PITG_14054T0; PITG_14054T0; PITG_14054.
DR   GeneID; 9468277; -.
DR   KEGG; pif:PITG_14054; -.
DR   VEuPathDB; FungiDB:PITG_14054; -.
DR   eggNOG; ENOG502RFQ3; Eukaryota.
DR   HOGENOM; CLU_071191_1_0_1; -.
DR   InParanoid; D0NNI8; -.
DR   OMA; SWHVLEM; -.
DR   OrthoDB; 1345205at2759; -.
DR   Proteomes; UP000006643; Partially assembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host nucleus; Reference proteome; Secreted; Signal; Virulence.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..229
FT                   /note="Secreted RxLR effector protein PITG_22926"
FT                   /id="PRO_5003012675"
FT   MOTIF           34..45
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:19741609"
SQ   SEQUENCE   229 AA;  26413 MW;  99C18CFE6065121D CRC64;
     MRCNHTLCVV AITFLVSWSQ TLSTPVESRR TESPLVRSVS ATEERNIFSQ TAEAVAKWGT
     TTALLNLGKT DDEVKKILGL EKLSGEALKA HSNYHLLDDF ITKLRDRKVT GWLHKDTTTD
     EVWKTLQLDD LFAKLDAKEF RHSDELKTYV QYVKKLDDDI WNYKRASFEP DSSSPLELAV
     KIHIWAKAKR PSWHVLEMMG NNALKGSKNR KFYREYLLLI KGKKPIIDF