ID   RXLR2_PHYPR             Reviewed;         158 AA.
AC   W2MBG9;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   19-MAR-2014, sequence version 1.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=Secreted RxLR effector protein 2 {ECO:0000303|PubMed:29165046};
DE   Flags: Precursor;
GN   Name=RxLR2 {ECO:0000303|PubMed:29165046}; ORFNames=L914_19142;
OS   Phytophthora parasitica (Potato buckeye rot agent).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=4792;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAC_01/95;
RG   The Broad Institute Genomics Platform;
RA   Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA   Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA   Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA   Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA   Wortman J., Nusbaum C., Birren B.;
RT   "The genome sequence of Phytophthora parasitica IAC_01/95.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   INDUCTION, AND FUNCTION.
RX   PubMed=29165046; DOI=10.1094/mpmi-07-17-0158-fi;
RA   Dalio R.J.D., Maximo H.J., Oliveira T.S., Dias R.O., Breton M.C.,
RA   Felizatti H., Machado M.;
RT   "Phytophthora parasitica effector PpRxLR2 suppresses Nicotiana benthamiana
RT   immunity.";
RL   Mol. Plant Microbe Interact. 31:481-493(2018).
CC   -!- FUNCTION: Secreted effector that completely suppresses elicitor-induced
CC       cell death in host and enhances virulence of P.parasitica.
CC       {ECO:0000269|PubMed:29165046}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:29165046}. Host cell
CC       {ECO:0000305|PubMed:29165046}.
CC   -!- INDUCTION: Expression is induced in presence of citrus root extracts or
CC       during the interaction with the susceptible host.
CC       {ECO:0000269|PubMed:29165046}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:29165046}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; KI695989; ETM33645.1; -; Genomic_DNA.
DR   AlphaFoldDB; W2MBG9; -.
DR   EnsemblProtists; ETM33645; ETM33645; L914_19142.
DR   VEuPathDB; FungiDB:PPTG_17847; -.
DR   Proteomes; UP000054532; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043657; C:host cell; IEA:UniProtKB-SubCell.
DR   InterPro; IPR031825; RXLR.
DR   Pfam; PF16810; RXLR; 1.
PE   2: Evidence at transcript level;
KW   Secreted; Signal; Virulence.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..158
FT                   /note="Secreted RxLR effector protein 2"
FT                   /id="PRO_5004819863"
FT   MOTIF           54..75
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:29165046"
SQ   SEQUENCE   158 AA;  18417 MW;  4B0422FDB2EACD55 CRC64;
     MRLLLWVLLV TLVTFLSSGD AAPVDSNKQL ERAAINKVTS RNLANDNSLK HEKRFLRGDR
     SNIVNLKDGD ENEERKIGQK MTTALKSIKV WYLKWEQKIL LPGFKKMAKK EMTYSKLMDR
     FRVRMMNSGR WGTPSGFKRY GRLYKDYLIS INRADLTV