ID   RXLR3_PHYPR             Reviewed;         127 AA.
AC   W2P2K7;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   19-MAR-2014, sequence version 1.
DT   25-MAY-2022, entry version 13.
DE   RecName: Full=Secreted RxLR effector protein 3 {ECO:0000303|PubMed:29165046};
DE   Flags: Precursor;
GN   Name=RxLR3 {ECO:0000303|PubMed:29165046}; ORFNames=L914_01796;
OS   Phytophthora parasitica (Potato buckeye rot agent).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=4792;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAC_01/95;
RG   The Broad Institute Genomics Platform;
RA   Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA   Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA   Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA   Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA   Wortman J., Nusbaum C., Birren B.;
RT   "The genome sequence of Phytophthora parasitica IAC_01/95.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   INDUCTION, AND FUNCTION.
RX   PubMed=29165046; DOI=10.1094/mpmi-07-17-0158-fi;
RA   Dalio R.J.D., Maximo H.J., Oliveira T.S., Dias R.O., Breton M.C.,
RA   Felizatti H., Machado M.;
RT   "Phytophthora parasitica effector PpRxLR2 suppresses Nicotiana benthamiana
RT   immunity.";
RL   Mol. Plant Microbe Interact. 31:481-493(2018).
CC   -!- FUNCTION: Secreted effector that partially suppresses elicitor-induced
CC       cell death in host and enhances virulence of P.parasitica.
CC       {ECO:0000269|PubMed:29165046}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:29165046}. Host cell
CC       {ECO:0000305|PubMed:29165046}.
CC   -!- INDUCTION: Expression is induced in presence of citrus root extracts or
CC       during the interaction with the susceptible host.
CC       {ECO:0000269|PubMed:29165046}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:29165046}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; KI690869; ETM54925.1; -; Genomic_DNA.
DR   AlphaFoldDB; W2P2K7; -.
DR   EnsemblProtists; ETM54925; ETM54925; L914_01796.
DR   VEuPathDB; FungiDB:PPTG_06988; -.
DR   Proteomes; UP000054532; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043657; C:host cell; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Secreted; Signal; Virulence.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..127
FT                   /note="Secreted RxLR effector protein 3"
FT                   /id="PRO_5004821246"
FT   MOTIF           30..48
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:29165046"
SQ   SEQUENCE   127 AA;  14526 MW;  7219A6E0C0D642AD CRC64;
     MRPPLLLFLT VTVLVSCASA VSTGNAAELR SLRSIKTTTN DDAAEEERGG FYHKFDLNFL
     DDIFHGLPEQ FQRMRNQPER LRTMFENWKT GWMSVDDAVA YMTREGLSEK AISQFKAAYQ
     AYLKHKG