ID   RXLR5_PHYPR             Reviewed;         180 AA.
AC   W2N2K3;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   19-MAR-2014, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=Secreted RxLR effector protein 5 {ECO:0000303|PubMed:29165046};
DE   Flags: Precursor;
GN   Name=RxLR3 {ECO:0000303|PubMed:29165046}; ORFNames=L914_11512;
OS   Phytophthora parasitica (Potato buckeye rot agent).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=4792;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAC_01/95;
RG   The Broad Institute Genomics Platform;
RA   Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA   Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA   Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA   Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA   Wortman J., Nusbaum C., Birren B.;
RT   "The genome sequence of Phytophthora parasitica IAC_01/95.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   INDUCTION, AND FUNCTION.
RX   PubMed=29165046; DOI=10.1094/mpmi-07-17-0158-fi;
RA   Dalio R.J.D., Maximo H.J., Oliveira T.S., Dias R.O., Breton M.C.,
RA   Felizatti H., Machado M.;
RT   "Phytophthora parasitica effector PpRxLR2 suppresses Nicotiana benthamiana
RT   immunity.";
RL   Mol. Plant Microbe Interact. 31:481-493(2018).
CC   -!- FUNCTION: Secreted effector that partially suppresses elicitor-induced
CC       cell death in host and enhances virulence of P.parasitica.
CC       {ECO:0000269|PubMed:29165046}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:29165046}. Host cell
CC       {ECO:0000305|PubMed:29165046}.
CC   -!- INDUCTION: Expression is induced in presence of citrus root extracts or
CC       during the interaction with the susceptible host.
CC       {ECO:0000269|PubMed:29165046}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:29165046}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; KI693697; ETM42907.1; -; Genomic_DNA.
DR   AlphaFoldDB; W2N2K3; -.
DR   SMR; W2N2K3; -.
DR   EnsemblProtists; ETM42907; ETM42907; L914_11512.
DR   VEuPathDB; FungiDB:PPTG_12769; -.
DR   Proteomes; UP000054532; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043657; C:host cell; IEA:UniProtKB-SubCell.
DR   InterPro; IPR031825; RXLR.
DR   Pfam; PF16810; RXLR; 1.
PE   2: Evidence at transcript level;
KW   Secreted; Signal; Virulence.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..180
FT                   /note="Secreted RxLR effector protein 5"
FT                   /id="PRO_5004820376"
FT   MOTIF           44..60
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:29165046"
SQ   SEQUENCE   180 AA;  20601 MW;  70626F528AC0AD78 CRC64;
     MRFYYTLLAT AAALLVHSDA LSAAAETSLN QLTAVDGTTT TSQRFLRRHT DSETTDNEER
     LNSGPIVLDT AKKIDDLFEV EKLDKILDPK MADKFLDGKT FFGWLDKSAL DEALNGNIAQ
     KTKVFEHWRE KRLRPKALTK VLTTDPAVRK KYKFVYEMYD SYIKYVARKK LSGLKRNRGD