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RXLRQ_PHYIT
ID   RXLRQ_PHYIT             Reviewed;         709 AA.
AC   D0NRP3;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2009, sequence version 1.
DT   03-AUG-2022, entry version 31.
DE   RecName: Full=RxLR effector protein PITG_15110 {ECO:0000303|PubMed:30329083};
DE   Flags: Precursor;
GN   ORFNames=PITG_15110;
OS   Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=403677;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND INDUCTION.
RC   STRAIN=T30-4;
RX   PubMed=19741609; DOI=10.1038/nature08358;
RG   The Broad Institute Genome Sequencing Platform;
RA   Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA   Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA   Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA   Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA   Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA   Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA   Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA   Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA   Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA   Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA   Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA   Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA   Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA   Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA   Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA   Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA   Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA   Nusbaum C.;
RT   "Genome sequence and analysis of the Irish potato famine pathogen
RT   Phytophthora infestans.";
RL   Nature 461:393-398(2009).
RN   [2]
RP   INDUCTION.
RX   PubMed=28228125; DOI=10.1186/s12864-017-3585-x;
RA   Ah-Fong A.M., Kim K.S., Judelson H.S.;
RT   "RNA-seq of life stages of the oomycete Phytophthora infestans reveals
RT   dynamic changes in metabolic, signal transduction, and pathogenesis genes
RT   and a major role for calcium signaling in development.";
RL   BMC Genomics 18:198-198(2017).
RN   [3]
RP   INDUCTION, AND DOMAIN.
RX   PubMed=29312401; DOI=10.3389/fpls.2017.02155;
RA   Yin J., Gu B., Huang G., Tian Y., Quan J., Lindqvist-Kreuze H., Shan W.;
RT   "Conserved RXLR effector genes of Phytophthora infestans expressed at the
RT   early stage of potato infection are suppressive to host defense.";
RL   Front. Plant Sci. 8:2155-2155(2017).
RN   [4]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=30329083; DOI=10.1093/jxb/ery360;
RA   Wang S., McLellan H., Bukharova T., He Q., Murphy F., Shi J., Sun S.,
RA   van Weymers P., Ren Y., Thilliez G., Wang H., Chen X., Engelhardt S.,
RA   Vleeshouwers V., Gilroy E.M., Whisson S.C., Hein I., Wang X., Tian Z.,
RA   Birch P.R.J., Boevink P.C.;
RT   "Phytophthora infestans RXLR effectors act in concert at diverse
RT   subcellular locations to enhance host colonization.";
RL   J. Exp. Bot. 70:343-356(2019).
CC   -!- FUNCTION: Effector that enhances P.infestans colonization of Nicotiana
CC       benthamiana leaves. {ECO:0000269|PubMed:30329083}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30329083}. Host
CC       cytoplasm, host cytoskeleton. Note=Associates with host microtubules.
CC       {ECO:0000269|PubMed:30329083}.
CC   -!- INDUCTION: Expression is induced during host plant infection.
CC       {ECO:0000269|PubMed:19741609, ECO:0000269|PubMed:28228125,
CC       ECO:0000269|PubMed:29312401}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:29312401}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; DS028155; EEY63393.1; -; Genomic_DNA.
DR   RefSeq; XP_002898278.1; XM_002898232.1.
DR   AlphaFoldDB; D0NRP3; -.
DR   SMR; D0NRP3; -.
DR   EnsemblProtists; PITG_15110T0; PITG_15110T0; PITG_15110.
DR   GeneID; 9475997; -.
DR   KEGG; pif:PITG_15110; -.
DR   VEuPathDB; FungiDB:PITG_15110; -.
DR   eggNOG; ENOG502SRJH; Eukaryota.
DR   HOGENOM; CLU_021192_3_0_1; -.
DR   InParanoid; D0NRP3; -.
DR   OMA; NTRRMAN; -.
DR   Proteomes; UP000006643; Partially assembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0044163; C:host cytoskeleton; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host cytoplasm; Host cytoskeleton; Reference proteome; Secreted; Signal;
KW   Virulence.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..709
FT                   /note="RxLR effector protein PITG_15110"
FT                   /id="PRO_5003012319"
FT   MOTIF           51..66
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:29312401"
SQ   SEQUENCE   709 AA;  79039 MW;  A9DFA34C7BF474B5 CRC64;
     MHAYSAAVLM GLLMVAEGAY VSTTACAHSA PNPTIQRYEP ESIPTRLAPN RLLREPETTE
     ASNEDRVVSI HAGIEKLSDL IKTGVSKVHG YLNLGPSATR DQPADEILRI YKLDDGIEKA
     LVSPNLKAME SHVKELSTKN RKSEASVIGI LTSHYGDDAV AKALVTAQKT VQSDDDVKTI
     WRLRNAQLSS WFSSDKSVDD VFTLLKLRHD DYLALASPKM EVLDDYMKLI NRVTSGQETL
     LNVLTKGFGG EQTMAKLLLR GKEEPQTREL ATALQNALLN KWVTDKFQPE SVLKKLKLDR
     DLMNALSDPT RHTLTSYIAV FNTRNPGKKA SFIGTLSAHY GDEMVANVLI AASRNGNTRR
     MANQLRTDQL SDWLNNQKSA DEVFSLLKLR ADLPNIDGAL ASGKLKLLED YIKLFNREKA
     GDETLLKTLT TGFDGESNLA KALLTAEINP HSNKMVVKLQ GELLNQWLLK GLKPESVLKN
     LGLDRGMKEV LSDPNRHFLT KYIWEYNSRN RFDRTSLILT LSAHYGDDVV ARALAVAKGD
     SGLARTAAIL QRQQLEGWLS SGKSADDVFT LLRIGADDFL PLNSQNLETL EDFVWLLNLK
     NRRIQTNIFT VVENKFGGDV QLARAVVKAL NEADERGLRD SVGIASRYRS KLFGRWFDKS
     IEPKDVYAMI LKVNGASADA LEKSIVSRYT AFYKKRLAKA FTFDSPRRL
 
 
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