ID   BECNB_DICDI             Reviewed;         855 AA.
AC   Q54JI9;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Beclin-1-like protein B;
DE   AltName: Full=Autophagy-related protein 6B;
GN   Name=atg6B; Synonyms=apg6B; ORFNames=DDB_G0288021;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   FUNCTION.
RX   PubMed=14736886; DOI=10.1074/jbc.m311139200;
RA   Otto G.P., Wu M.Y., Kazgan N., Anderson O.R., Kessin R.H.;
RT   "Dictyostelium macroautophagy mutants vary in the severity of their
RT   developmental defects.";
RL   J. Biol. Chem. 279:15621-15629(2004).
CC   -!- FUNCTION: Involved in autophagy. May be required to recruit the atg8-
CC       phosphatidylinositol conjugate and the atg12-atg5 conjugate to the pre-
CC       autophagosomal structure (By similarity). {ECO:0000250,
CC       ECO:0000269|PubMed:14736886}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beclin family. {ECO:0000305}.
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DR   EMBL; AAFI02000107; EAL63436.1; -; Genomic_DNA.
DR   RefSeq; XP_636942.1; XM_631850.1.
DR   AlphaFoldDB; Q54JI9; -.
DR   SMR; Q54JI9; -.
DR   STRING; 44689.DDB0220127; -.
DR   PaxDb; Q54JI9; -.
DR   EnsemblProtists; EAL63436; EAL63436; DDB_G0288021.
DR   GeneID; 8626417; -.
DR   KEGG; ddi:DDB_G0288021; -.
DR   dictyBase; DDB_G0288021; atg6B.
DR   eggNOG; KOG2751; Eukaryota.
DR   HOGENOM; CLU_334177_0_0_1; -.
DR   InParanoid; Q54JI9; -.
DR   OMA; DAFHLWH; -.
DR   Reactome; R-DDI-1632852; Macroautophagy.
DR   Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR   PRO; PR:Q54JI9; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000407; C:phagophore assembly site; IBA:GO_Central.
DR   GO; GO:0034271; C:phosphatidylinositol 3-kinase complex, class III, type I; IBA:GO_Central.
DR   GO; GO:0034272; C:phosphatidylinositol 3-kinase complex, class III, type II; IBA:GO_Central.
DR   GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central.
DR   GO; GO:0006995; P:cellular response to nitrogen starvation; IBA:GO_Central.
DR   GO; GO:0045324; P:late endosome to vacuole transport; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.418.40; -; 1.
DR   InterPro; IPR007243; Atg6/Beclin.
DR   InterPro; IPR038274; Atg6/Beclin_C_sf.
DR   InterPro; IPR041691; Atg6/beclin_CC.
DR   InterPro; IPR040455; Atg6_BARA.
DR   PANTHER; PTHR12768; PTHR12768; 1.
DR   Pfam; PF04111; APG6; 1.
DR   Pfam; PF17675; APG6_N; 1.
PE   3: Inferred from homology;
KW   Autophagy; Coiled coil; Endosome; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..855
FT                   /note="Beclin-1-like protein B"
FT                   /id="PRO_0000327430"
FT   REGION          92..212
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          236..271
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          294..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          407..475
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          826..855
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          538..595
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        95..120
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..212
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        410..475
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   855 AA;  94924 MW;  484CC2E8EC37E0B0 CRC64;
     MDLYCQKCYK QLELDDSLLD IDQSLFLKTN IHEIIEELEE LSLKPVPKER ETLILKQQQQ
     QLLQQQEQAA AAAAIQSPQT VSKMSKLKSG LFGKRKELTQ SNSTTPTTPA TPTATPTSSS
     LSLPTPPPLP QQQQQQQQQQ QQTFNDQSKL TATTPTQPTP IEEKKQQSFK TFYPAAHSNN
     SSNGSDHGGN VNTTGVSPSS PGGGAHSFGS LSQHRLSSSL SLKSISSGGG NSSSNLVADI
     NNNNNSVNKD NNTTISSSTV TTSNSISESN NQDSKLLVAT TTTTTTTTTT TILATIPTTT
     TTSTPTTPST VGGTTPSPPS SSSSSSSSSS VITSPISRIS PSNITSPSKL SQQSTPRQRP
     LTIAPTKLNI SQVSSPQKPR LKYLRTSSKS LSMASLPAVG PDGTIIVDGG ASSGTESTSM
     TNHHSSFLNQ STLPLGSSPV QTTPPLLSNS MNNSTNNLQS LQQQQQQQQQ QQQQPISENN
     YYKYMKGLSL FKIATDLINY DLPLCLECTK LTIGELEDEG SILDGEVSIY SAYLKQLEKG
     KTEEDLEELG KEMTLLCEEE EQLRLMIENT HQERKEVEQL TLQLQDRIAT LKSLEDSYWS
     CFSEFHYETF RNKDERDQTT VQIQWVNDHL ESLKQTNILN DAFHLWHDGH FGTINSLRLG
     KLPSQPVEWN EINAAWGLAV SLLDAMAKKL KFKFQQFTLV PNGSCSRVDK RDVDPPLAYE
     LYGTNDISLG RLFWYRRFDN GMIAFLQCIK ELCEHITEKD PEFSVPYKID KEYIGGMCIK
     LQFTNDDTWT KSLKFMLTNL KWILIWIVKN ETLTLFNNQQ FQQSKLNNNQ NNNNINNNNN
     NNINNNNNNN VNKRN