ABCGB_DICDI
ID ABCGB_DICDI Reviewed; 1442 AA.
AC Q55DQ2; Q8T681;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=ABC transporter G family member 11;
DE AltName: Full=ABC transporter ABCG.11;
GN Name=abcG11; ORFNames=DDB_G0269212;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF482390; AAL91497.1; -; Genomic_DNA.
DR EMBL; AAFI02000005; EAL71956.1; -; Genomic_DNA.
DR RefSeq; XP_646079.1; XM_640987.1.
DR AlphaFoldDB; Q55DQ2; -.
DR SMR; Q55DQ2; -.
DR STRING; 44689.DDB0191518; -.
DR PaxDb; Q55DQ2; -.
DR EnsemblProtists; EAL71956; EAL71956; DDB_G0269212.
DR GeneID; 8617029; -.
DR KEGG; ddi:DDB_G0269212; -.
DR dictyBase; DDB_G0269212; abcG11.
DR eggNOG; KOG0065; Eukaryota.
DR HOGENOM; CLU_000604_35_6_1; -.
DR InParanoid; Q55DQ2; -.
DR OMA; SSWGQWI; -.
DR PhylomeDB; Q55DQ2; -.
DR PRO; PR:Q55DQ2; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IGC:dictyBase.
DR GO; GO:0031152; P:aggregation involved in sorocarp development; IBA:GO_Central.
DR GO; GO:0031288; P:sorocarp morphogenesis; IBA:GO_Central.
DR CDD; cd03233; ABCG_PDR_domain1; 1.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR029481; ABC_trans_N.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034001; ABCG_PDR_1.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010929; PDR_CDR_ABC.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF14510; ABC_trans_N; 1.
DR Pfam; PF06422; PDR_CDR; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1442
FT /note="ABC transporter G family member 11"
FT /id="PRO_0000391398"
FT TRANSMEM 482..502
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 518..538
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 567..587
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 592..612
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 627..647
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 737..757
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1147..1167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1181..1201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1220..1240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1259..1279
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1286..1306
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1416..1436
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 125..373
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 478..718
FT /note="ABC transmembrane type-2 1"
FT DOMAIN 808..1052
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1144..1369
FT /note="ABC transmembrane type-2 2"
FT BINDING 844..851
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CONFLICT 1157..1164
FT /note="GLIIGFTF -> VKYWFYI (in Ref. 1; AAL91497)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1442 AA; 164045 MW; 6BFEB0051BEE9CF2 CRC64;
MVHNNDGDNN DQEMQEIGIN EKRSQFPHIS VEESRQEFDS FSNNIEGESK QFGMNRDAES
NMAVESEEDF KLRKYFENSN RMHLENGGNE KKMGVSIRNL TVVGLGADAS VIADMSTPFY
GLVKLFTPSF WTKKTSTFDI LHDVTTFCKD GEMVLVLGRP GAGCSTLLRV IANQTASYVS
VKGDITYGGI PSKEFEKYRG EPIYTPEEDS HHPTLTVRET LDFALKCKTP GNRLPDETKR
SFRDKVFNLL LSMFGIVHQA DTIVGNEFIR GLSGGERKRL TITEAMVSSA SITCWDCSTR
GLDAASAFDY AKSIRIMSDT LHKTTIASFY QASDSIYNVF DKVCVLEKGR CIYFGPVGMA
KQYFMSLGFD CEPRKSTPDF LTGVTNPQER IIKKGFEGRT PETSADFEEA WKNSDIYRDQ
LQEQKEYEEL IERTQPKVAF VQEVRDANSK TNFKKSQYTT SFVTQVIALI KRNFALVLND
KFGMYSKYLS VLIQGFVYAS LFYNMDTDIT GLFTRGGAIL SAVIFNAFLS IGEMAMTFYG
RRVLQKHKSY ALYRPSALHI AQVVTDIPFT AIQVFLFSII AYFMFGLQYD AGKFFIFCFT
LLGASLACTA LFRCFGYLCP SMYIAQNISN VFIIFMLTYS GYTIPIPKMH PWFSWFRHIN
IFTYAFKALM ANEFEGLDFN CKESAIPYGP AYQGSEFDAY RICPLGGIEQ GSLYFKGDFY
MDKTLSFATG EMSQNVIIVY CWWVFFVVCN MFAMEYIDHT SGGYTHKVYK KGKAPKMNDV
EEEKQQNAIV AKATSNMKDT LHMDGGIFTW QNIRYTVKVP GGERLLLDNI EGWIKPGQMT
ALMGSSGAGK TTLLDVLAKR KTLGVVEGDS HLNGRELEID FERITGYVEQ MDVHNPGLTV
REALRFSAKL RQEPEVSLEE KFKYVEHVLE MMEMKHLGDA LIGTLETGVG ISVEERKRLT
IGVELVAKPQ ILFLDEPTSG LDAQSSYNII KFIRKLADAG MPLVCTIHQP SSVLFEHFDR
ILLLAKGGKT VYFGDIGEKS KTLTSYFERH GVRPCTESEN PAEYILEATG AGVHGKSDVN
WPEAWKQSPE LADISRELAA LKEQGAQQYK PRSDGPAREF SQSTWYQTKE VYKRLNLIWW
RDPYYTYGSF VQAALCGLII GFTFWNLQGS SSDMNQRIFF IFEALMLGIL LIFVVMPQLI
IQREYFKRDF ASKFYSWFPF AISIVVVELP FIVISGTIFF FCSFWTAGLH KTSDDEQTFY
FWFIFIIFMF FCVSFGQAVA AVCINMFFAM TLIPLLIVFL FLFCGVMVPP SSIPTFWRGW
VYHLNPCRYF MEGIITNILK TVRVECSEED MAIFTFPKSY NTCQNYTSAF QSYKPSGYVE
SATLNGEPAC GYCIYKNGEE YYETLGWSAD NRWRNVGIII GFFVFNILMV ILFVYLTRKG
SR
