ID   RX_DUGJA                Reviewed;         268 AA.
AC   O97039;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Retinal homeobox protein Rax;
DE   AltName: Full=DjRax;
DE   Flags: Fragment;
GN   Name=RAX;
OS   Dugesia japonica (Planarian).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Seriata; Tricladida; Continenticola; Geoplanoidea;
OC   Dugesiidae; Dugesia.
OX   NCBI_TaxID=6161;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=GI;
RA   Sakai F., Agata K., Orii H., Umesono Y., Watanabe K.;
RT   "Organization and reorganization of the eye in the planarian, Dugesia
RT   japonica.";
RL   Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the ventral forebrain.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AB017633; BAA75673.1; -; mRNA.
DR   AlphaFoldDB; O97039; -.
DR   SMR; O97039; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR032967; Rx-like.
DR   PANTHER; PTHR24329:SF405; PTHR24329:SF405; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           <1..268
FT                   /note="Retinal homeobox protein Rax"
FT                   /id="PRO_0000049287"
FT   DNA_BIND        87..146
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          56..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..80
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   268 AA;  30986 MW;  5C9D97E4B59A865B CRC64;
     INKRYNIDDI LGIPDQKSLM LNNYQHQSVV ENEICDSYQK KDISVNNREL LMVKRCPKDS
     SEQSPAISEA DETESSPDQL SNCNKKHRRN RTTFTTYQLH ELERAFEKSH YPDVYSREEL
     AMKISLPEVR VQVWFQNRRA KWRRQEKIEA ANHTHNLQEV FPNVGKSLTS SLFPANPYPF
     LNMSLPSVES TSFFYHQNGM LNPMSMVNNL GFSNFSSLNL EPPKIPMTLP YGLFNEFSNF
     LSTRSSSKDL NSNSKTCSIR TADNLNTE