RX_RAT
ID RX_RAT Reviewed; 342 AA.
AC Q9JLT7; Q99PA4;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Retinal homeobox protein Rx;
DE AltName: Full=Retina and anterior neural fold homeobox protein;
GN Name=Rax; Synonyms=Rx;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE, AND ALTERNATIVE INITIATION.
RC STRAIN=Sprague-Dawley;
RA Tucker P., Laemle L., Munson A., Kanekar S., Schlecht H., Vetter M.,
RA Glaser T.;
RT "The eyeless mouse mutation (ey1) removes an alternative start codon from
RT the Rx/rax homeobox gene and acts as a hypomorphic allele.";
RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE.
RA Nishida K., Gage F.H.;
RT "Transcription factor cascade for neural progenitor differentiation into
RT retinal neuron.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a critical role in eye formation by regulating the
CC initial specification of retinal cells and/or their subsequent
CC proliferation. Binds to the photoreceptor conserved element-I (PCE-
CC 1/Ret 1) in the photoreceptor cell-specific arrestin promoter (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative initiation; Named isoforms=2;
CC Name=Long;
CC IsoId=Q9JLT7-1; Sequence=Displayed;
CC Name=Short;
CC IsoId=Q9JLT7-2; Sequence=VSP_018806;
CC -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC {ECO:0000305}.
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DR EMBL; AF320225; AAK07422.1; -; Genomic_DNA.
DR EMBL; AF320224; AAK07422.1; JOINED; Genomic_DNA.
DR EMBL; AF320225; AAK07423.1; -; Genomic_DNA.
DR EMBL; AF320224; AAK07423.1; JOINED; Genomic_DNA.
DR EMBL; AF135839; AAF61631.1; -; mRNA.
DR RefSeq; NP_446130.1; NM_053678.1. [Q9JLT7-1]
DR AlphaFoldDB; Q9JLT7; -.
DR SMR; Q9JLT7; -.
DR STRING; 10116.ENSRNOP00000022785; -.
DR PaxDb; Q9JLT7; -.
DR Ensembl; ENSRNOT00000022784; ENSRNOP00000022785; ENSRNOG00000016944. [Q9JLT7-1]
DR GeneID; 114213; -.
DR KEGG; rno:114213; -.
DR UCSC; RGD:620371; rat. [Q9JLT7-1]
DR CTD; 30062; -.
DR RGD; 620371; Rax.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000162144; -.
DR InParanoid; Q9JLT7; -.
DR OrthoDB; 1085093at2759; -.
DR PhylomeDB; Q9JLT7; -.
DR PRO; PR:Q9JLT7; -.
DR Proteomes; UP000002494; Chromosome 18.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0007420; P:brain development; ISO:RGD.
DR GO; GO:0043010; P:camera-type eye development; ISO:RGD.
DR GO; GO:0021854; P:hypothalamus development; ISO:RGD.
DR GO; GO:0060173; P:limb development; ISO:RGD.
DR GO; GO:0007389; P:pattern specification process; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR InterPro; IPR043562; RAX/RAX2.
DR PANTHER; PTHR46271; PTHR46271; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 2: Evidence at transcript level;
KW Alternative initiation; Developmental protein; DNA-binding; Homeobox;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..342
FT /note="Retinal homeobox protein Rx"
FT /id="PRO_0000013493"
FT DNA_BIND 137..196
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 49..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 33..40
FT /note="Octapeptide motif"
FT MOTIF 319..332
FT /note="OAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT MOTIF 325..329
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 49..69
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..295
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..9
FT /note="Missing (in isoform Short)"
FT /evidence="ECO:0000305"
FT /id="VSP_018806"
SQ SEQUENCE 342 AA; 36337 MW; 03CD1F495EE64EC3 CRC64;
MHLPGCPPAM ADGSFSLAGH LLRSPGGSTS RLHSIEAILG FTKEDGILDT FPAERSSRGS
KERDPRLGAR SACPKAPAGG SESSPPAAPG LVPEFEATRP CYPKEQGEAR PSPGLPVGPA
AGDSKLSEEE EPPKKKHRRN RTTFTTYQLH ELERAFEKSH YPDVYSREEL AGKVNLPEVR
VQVWFQNRRA KWRRQEKLEV SSMKLQDSPL LSFSRSPPSS ALAPLGGPGS GSGPPGSALP
LEPWLGPPLP GGGATALQSL PGFGPPGQGL PASYTPPPPF LNSAPLGPGL QQLGPPPAYP
CAPAFGDKFS LEEAYPRNSS IAALRLKAKE HIQAIGKPWQ AL
