ID   RYBPA_DANRE             Reviewed;         385 AA.
AC   Q7SYB3;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=RING1 and YY1-binding protein A;
DE   AltName: Full=Death effector domain-associated factor A;
DE            Short=DED-associated factor A;
GN   Name=rybpa {ECO:0000312|ZFIN:ZDB-GENE-030424-3};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000312|EMBL:AAH54937.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB {ECO:0000312|EMBL:AAH54937.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be implicated in the regulation of the transcription as a
CC       repressor of the transcriptional activity of E4TF1.
CC       {ECO:0000250|UniProtKB:Q8N488}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8N488}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8N488}. Note=Primarily found in the nucleus.
CC       {ECO:0000250|UniProtKB:Q8N488}.
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DR   EMBL; BC054937; AAH54937.1; -; mRNA.
DR   AlphaFoldDB; Q7SYB3; -.
DR   SMR; Q7SYB3; -.
DR   STRING; 7955.ENSDARP00000055037; -.
DR   PaxDb; Q7SYB3; -.
DR   ZFIN; ZDB-GENE-030424-3; rybpa.
DR   eggNOG; KOG4477; Eukaryota.
DR   InParanoid; Q7SYB3; -.
DR   PhylomeDB; Q7SYB3; -.
DR   PRO; PR:Q7SYB3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR039958; RYBP/YAF2.
DR   InterPro; IPR033774; YAF2_RYBP.
DR   InterPro; IPR001876; Znf_RanBP2.
DR   InterPro; IPR036443; Znf_RanBP2_sf.
DR   PANTHER; PTHR12920; PTHR12920; 1.
DR   Pfam; PF17219; YAF2_RYBP; 1.
DR   Pfam; PF00641; zf-RanBP; 1.
DR   SMART; SM00547; ZnF_RBZ; 1.
DR   SUPFAM; SSF90209; SSF90209; 1.
DR   PROSITE; PS01358; ZF_RANBP2_1; 1.
DR   PROSITE; PS50199; ZF_RANBP2_2; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..385
FT                   /note="RING1 and YY1-binding protein A"
FT                   /id="PRO_0000299078"
FT   ZN_FING         19..48
FT                   /note="RanBP2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00322"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          63..317
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          331..385
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..153
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        156..190
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        191..221
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        232..257
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        258..272
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        289..317
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        331..367
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        368..385
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   385 AA;  43295 MW;  F401743C6389F7ED CRC64;
     MGDKKSPSRP KRQAKPSADN GFWDCSVCTF KNSAEAFKCS ICDVRKGTST RKPRINSQLV
     AQQVAQQYAA PPPAKKERRE RTDRDLPDDD HFDMDNSDSD RLSSLHPDSD HPERLGLEGG
     QLDRGHSLKE RRQERVLDKP QALDTDRRPE RAGLTPDLLQ QQQPQPQQHP QQPQQPQQHS
     QQQPQQHPPQ QHNRIDREHT DRAMLEKLQP LREHMEKDHP HTAGSGMQPA ERMGAEREEL
     KKGKIERAMM EKHKERHKSL TPSKKPTPKK MKPKLIQKSP AGESNGMKPG KSVTKNNKSV
     ISRPKLKNVD RSSAQQLAIT VGNVTVIITD FKEKTRSSST SSSTVTSSAG SEQQHLSSSS
     ESTDKGSSRA STPRRDHSSG HNETL