ID   RYBPB_DANRE             Reviewed;         257 AA.
AC   Q5EG55; A0JMJ2;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=RING1 and YY1-binding protein B;
DE   AltName: Full=Death effector domain-associated factor B;
DE            Short=DED-associated factor B;
GN   Name=rybpb; Synonyms=dedaf; ORFNames=zgc:153842;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Cheng C.-M., Yuo C.-Y.;
RT   "Zebrafish novel protein similar to human death effector domain-associated
RT   factor.";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=WIK; TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be implicated in the regulation of the transcription as a
CC       repressor of the transcriptional activity of E4TF1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Primarily found in the nucleus. {ECO:0000250}.
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DR   EMBL; AY885249; AAW79577.1; -; mRNA.
DR   EMBL; BC125899; AAI25900.1; -; mRNA.
DR   RefSeq; NP_001012373.1; NM_001012373.2.
DR   AlphaFoldDB; Q5EG55; -.
DR   SMR; Q5EG55; -.
DR   STRING; 7955.ENSDARP00000069979; -.
DR   PaxDb; Q5EG55; -.
DR   GeneID; 497613; -.
DR   KEGG; dre:497613; -.
DR   CTD; 497613; -.
DR   ZFIN; ZDB-GENE-061103-96; rybpb.
DR   eggNOG; KOG4477; Eukaryota.
DR   InParanoid; Q5EG55; -.
DR   OrthoDB; 1634090at2759; -.
DR   PhylomeDB; Q5EG55; -.
DR   Reactome; R-DRE-8939243; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.
DR   Reactome; R-DRE-8953750; Transcriptional Regulation by E2F6.
DR   PRO; PR:Q5EG55; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR039958; RYBP/YAF2.
DR   InterPro; IPR033774; YAF2_RYBP.
DR   InterPro; IPR001876; Znf_RanBP2.
DR   InterPro; IPR036443; Znf_RanBP2_sf.
DR   PANTHER; PTHR12920; PTHR12920; 1.
DR   Pfam; PF17219; YAF2_RYBP; 1.
DR   Pfam; PF00641; zf-RanBP; 1.
DR   SMART; SM00547; ZnF_RBZ; 1.
DR   SUPFAM; SSF90209; SSF90209; 1.
DR   PROSITE; PS01358; ZF_RANBP2_1; 1.
DR   PROSITE; PS50199; ZF_RANBP2_2; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..257
FT                   /note="RING1 and YY1-binding protein B"
FT                   /id="PRO_0000097549"
FT   ZN_FING         19..48
FT                   /note="RanBP2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00322"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          45..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..150
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        151..171
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        180..195
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        202..246
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   257 AA;  28667 MW;  FFE563D49F16DE25 CRC64;
     MGDKKSPTRP KRQAKPTADN GFWDCSVCTF RNSAEAFKCS ICDVRKGTST RKPRINSQLV
     AQQVAQQYAT PPPPKKEKKE KPERPEKDRA EEERPDINPP DEHPVEQRDK DKSEKEQPEK
     EKKDREKEII PAITKKPNSK KNRPKSDIHQ SPPSERNSIQ SGKSTTKTKN SHNSRPKLKN
     IDRSTAQQLA ITVGNVTVII TDFKEKTRTS STSSSTVTSS ASSEQQHQSS GSESMDKGSS
     RASTPKGDLS LGHDESF