BEE1_ARATH
ID BEE1_ARATH Reviewed; 260 AA.
AC Q8GZ13; Q9LPQ6;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Transcription factor BEE 1;
DE AltName: Full=Basic helix-loop-helix protein 44;
DE Short=AtbHLH44;
DE Short=bHLH 44;
DE AltName: Full=Protein Brassinosteroid enhanced expression 1;
DE AltName: Full=Transcription factor EN 77;
DE AltName: Full=bHLH transcription factor bHLH044;
GN Name=BEE1; Synonyms=BHLH44, EN77; OrderedLocusNames=At1g18400;
GN ORFNames=F15H18.11, F15H18.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=12454087; DOI=10.1093/genetics/162.3.1445;
RA Friedrichsen D.M., Nemhauser J., Muramitsu T., Maloof J.N., Alonso J.,
RA Ecker J.R., Furuya M., Chory J.;
RT "Three redundant brassinosteroid early response genes encode putative bHLH
RT transcription factors required for normal growth.";
RL Genetics 162:1445-1456(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GENE FAMILY, AND
RP NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [7]
RP GENE FAMILY.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [8]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
CC -!- FUNCTION: Positive regulator of brassinosteroid signaling.
CC {ECO:0000269|PubMed:12454087}.
CC -!- INTERACTION:
CC Q8GZ13; Q38845: PP2AA1; NbExp=3; IntAct=EBI-4440101, EBI-1645478;
CC Q8GZ13; Q9FHZ1: SCL23; NbExp=5; IntAct=EBI-4440101, EBI-1238460;
CC Q8GZ13; Q9LQF0: TCP23; NbExp=3; IntAct=EBI-4440101, EBI-15192297;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- INDUCTION: Induced by brassinosteroid, auxin, ethylene and cytokinin,
CC and repressed by abscisic acid. Insensitive to gibberellic acid.
CC {ECO:0000269|PubMed:12454087}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype. Redundant with BEE2 and
CC BEE3. {ECO:0000269|PubMed:12454087}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF25996.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 2 genes: At1g18390 and At1g18400.; Evidence={ECO:0000305};
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DR EMBL; AY138253; AAN18283.1; -; mRNA.
DR EMBL; AF488579; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC013354; AAF25996.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE29711.1; -; Genomic_DNA.
DR EMBL; AK117269; BAC41942.1; -; mRNA.
DR EMBL; BT005268; AAO63332.1; -; mRNA.
DR RefSeq; NP_173276.2; NM_101698.3.
DR AlphaFoldDB; Q8GZ13; -.
DR SMR; Q8GZ13; -.
DR BioGRID; 23660; 17.
DR IntAct; Q8GZ13; 16.
DR MINT; Q8GZ13; -.
DR STRING; 3702.AT1G18400.1; -.
DR PaxDb; Q8GZ13; -.
DR PRIDE; Q8GZ13; -.
DR EnsemblPlants; AT1G18400.1; AT1G18400.1; AT1G18400.
DR GeneID; 838421; -.
DR Gramene; AT1G18400.1; AT1G18400.1; AT1G18400.
DR KEGG; ath:AT1G18400; -.
DR Araport; AT1G18400; -.
DR TAIR; locus:2014144; AT1G18400.
DR eggNOG; ENOG502QTM9; Eukaryota.
DR HOGENOM; CLU_089115_0_0_1; -.
DR OMA; NTTKTGC; -.
DR OrthoDB; 1206509at2759; -.
DR PhylomeDB; Q8GZ13; -.
DR PRO; PR:Q8GZ13; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8GZ13; baseline and differential.
DR Genevisible; Q8GZ13; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003677; F:DNA binding; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:1902448; P:positive regulation of shade avoidance; IMP:TAIR.
DR GO; GO:2000762; P:regulation of phenylpropanoid metabolic process; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR GO; GO:0006351; P:transcription, DNA-templated; IMP:TAIR.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR031064; bHLH_BEE-like_plant.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR024097; bHLH_ZIP_TF.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR12565; PTHR12565; 1.
DR PANTHER; PTHR12565:SF346; PTHR12565:SF346; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..260
FT /note="Transcription factor BEE 1"
FT /id="PRO_0000302042"
FT DOMAIN 151..201
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 118..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 144
FT /note="H -> P (in Ref. 2; AF488579)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 260 AA; 29364 MW; 404B546423859BA1 CRC64;
MANFENLSSD FQTIAMDIYS SITQAADLNN NNSNLHFQTF HPSSTSLESL FLHHHQQQLL
HFPGNSPDSS NNFSSTSSFL HSDHNIVDET KKRKALLPTL SSSETSGVSD NTNVIATETG
SLRRGKRLKK KKEEEDEKER EVVHVRARRG QATDSHSLAE RVRRGKINER LRCLQDMVPG
CYKAMGMATM LDEIINYVQS LQNQVEFLSM KLTAASSFYD FNSETDAVDS MQRAKARETV
EMGRQTRDGS PVFHLSTWSL
