ID   RZPD_ECOLI              Reviewed;         153 AA.
AC   P75719; P77084; Q2MBM5;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Prophage Rz endopeptidase RzpD {ECO:0000305};
DE            EC=3.4.-.-;
GN   Name=rzpD; Synonyms=ybcT; OrderedLocusNames=b0556, JW5079;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RA   Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA   Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA   Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT   "Sequence of minutes 4-25 of Escherichia coli.";
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- FUNCTION: Necessary for host cell lysis. It is believed to code for an
CC       endopeptidase that cleaves the amino-carboxyl cross-link between the
CC       diaminopimelic acid and D-alanine residues in the murein component of
CC       the bacterial cell wall (By similarity). {ECO:0000250}.
CC   -!- MISCELLANEOUS: Encoded by the cryptic lambdoid prophage DLP12.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB40752.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; U82598; AAB40752.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U00096; AAC73657.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76331.1; -; Genomic_DNA.
DR   PIR; B64788; B64788.
DR   RefSeq; NP_415088.1; NC_000913.3.
DR   AlphaFoldDB; P75719; -.
DR   SMR; P75719; -.
DR   BioGRID; 4262925; 2.
DR   STRING; 511145.b0556; -.
DR   MEROPS; X19.001; -.
DR   PaxDb; P75719; -.
DR   PRIDE; P75719; -.
DR   EnsemblBacteria; AAC73657; AAC73657; b0556.
DR   EnsemblBacteria; BAE76331; BAE76331; BAE76331.
DR   GeneID; 945929; -.
DR   KEGG; ecj:JW5079; -.
DR   KEGG; eco:b0556; -.
DR   PATRIC; fig|1411691.4.peg.1719; -.
DR   EchoBASE; EB3400; -.
DR   eggNOG; ENOG50330HV; Bacteria.
DR   HOGENOM; CLU_117687_2_0_6; -.
DR   InParanoid; P75719; -.
DR   OMA; QCVSTAS; -.
DR   PhylomeDB; P75719; -.
DR   BioCyc; EcoCyc:G6311-MON; -.
DR   PRO; PR:P75719; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0019076; P:viral release from host cell; IEA:InterPro.
DR   HAMAP; MF_04137; I_SPANIN_LAMBDA; 1.
DR   InterPro; IPR004929; I-spanin.
DR   Pfam; PF03245; Phage_lysis; 1.
PE   3: Inferred from homology;
KW   Antimicrobial; Bacteriolytic enzyme; Hydrolase; Protease;
KW   Reference proteome.
FT   CHAIN           1..153
FT                   /note="Prophage Rz endopeptidase RzpD"
FT                   /id="PRO_0000077572"
SQ   SEQUENCE   153 AA;  17226 MW;  AAACE549D943B2FC CRC64;
     MSRVTAIISA LIICIIVSLS WAVNHYRDNA IAYKVQRDKN ARELKLANAA ITDMQMRQRD
     VAALDAKYTK ELADAKAEND ALRDDVAAGR RRLHIKAVCQ SVREATTASG VDNAASPRLA
     DTAERDYFTL RERLITMQKQ LEGTQKYINE QCR