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S100G_MOUSE
ID   S100G_MOUSE             Reviewed;          79 AA.
AC   P97816;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 148.
DE   RecName: Full=Protein S100-G;
DE   AltName: Full=Calbindin-D9k;
DE   AltName: Full=S100 calcium-binding protein G;
DE   AltName: Full=Vitamin D-dependent calcium-binding protein, intestinal;
DE            Short=CABP;
GN   Name=S100g; Synonyms=Calb3, S100d;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=CD-1 / ICR;
RA   Tatsumi K., Higuchi T., Fujiwara H., Nakayama T., Itoh K., Mori T.,
RA   Fujita J.;
RL   Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 23-62.
RC   STRAIN=ICR; TISSUE=Placenta;
RA   Ogura Y., Takakura N., Yoshida H., Nishikawa S.;
RL   Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Kidney;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SIMILARITY: Belongs to the S-100 family. {ECO:0000305}.
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DR   EMBL; AF028071; AAB84041.1; -; mRNA.
DR   EMBL; U88544; AAB48839.1; -; mRNA.
DR   CCDS; CCDS41203.1; -.
DR   RefSeq; NP_033919.1; NM_009789.2.
DR   AlphaFoldDB; P97816; -.
DR   SMR; P97816; -.
DR   STRING; 10090.ENSMUSP00000045120; -.
DR   iPTMnet; P97816; -.
DR   PhosphoSitePlus; P97816; -.
DR   jPOST; P97816; -.
DR   PaxDb; P97816; -.
DR   PeptideAtlas; P97816; -.
DR   PRIDE; P97816; -.
DR   ProteomicsDB; 255431; -.
DR   Antibodypedia; 4324; 77 antibodies from 15 providers.
DR   DNASU; 12309; -.
DR   Ensembl; ENSMUST00000038769; ENSMUSP00000045120; ENSMUSG00000040808.
DR   GeneID; 12309; -.
DR   KEGG; mmu:12309; -.
DR   UCSC; uc009uus.1; mouse.
DR   CTD; 795; -.
DR   MGI; MGI:104528; S100g.
DR   VEuPathDB; HostDB:ENSMUSG00000040808; -.
DR   eggNOG; ENOG502T3Z3; Eukaryota.
DR   GeneTree; ENSGT00530000064238; -.
DR   HOGENOM; CLU_138624_4_0_1; -.
DR   InParanoid; P97816; -.
DR   OMA; QKYAAKE; -.
DR   OrthoDB; 1558629at2759; -.
DR   PhylomeDB; P97816; -.
DR   BioGRID-ORCS; 12309; 1 hit in 72 CRISPR screens.
DR   ChiTaRS; S100g; mouse.
DR   PRO; PR:P97816; -.
DR   Proteomes; UP000000589; Chromosome X.
DR   RNAct; P97816; protein.
DR   Bgee; ENSMUSG00000040808; Expressed in duodenum and 58 other tissues.
DR   ExpressionAtlas; P97816; baseline and differential.
DR   Genevisible; P97816; MM.
DR   GO; GO:0016324; C:apical plasma membrane; IDA:MGI.
DR   GO; GO:0016323; C:basolateral plasma membrane; IDA:MGI.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0048306; F:calcium-dependent protein binding; IBA:GO_Central.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   GO; GO:0005499; F:vitamin D binding; IEA:UniProtKB-KW.
DR   CDD; cd00213; S-100; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR034325; S-100_dom.
DR   InterPro; IPR001751; S100/CaBP7/8-like_CS.
DR   InterPro; IPR013787; S100_Ca-bd_sub.
DR   InterPro; IPR028489; S100G.
DR   PANTHER; PTHR11639:SF73; PTHR11639:SF73; 1.
DR   Pfam; PF00036; EF-hand_1; 1.
DR   Pfam; PF01023; S_100; 1.
DR   SMART; SM00054; EFh; 1.
DR   SMART; SM01394; S_100; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS00303; S100_CABP; 1.
PE   1: Evidence at protein level;
KW   Calcium; Metal-binding; Phosphoprotein; Reference proteome; Repeat;
KW   Vitamin D.
FT   CHAIN           1..79
FT                   /note="Protein S100-G"
FT                   /id="PRO_0000144028"
FT   DOMAIN          13..48
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000305"
FT   DOMAIN          45..79
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         26
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /ligand_note="low affinity"
FT                   /evidence="ECO:0000305"
FT   BINDING         31
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /ligand_note="low affinity"
FT                   /evidence="ECO:0000305"
FT   BINDING         58
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /ligand_note="high affinity"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         60
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /ligand_note="high affinity"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         62
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /ligand_note="high affinity"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         64
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /ligand_note="high affinity"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         69
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /ligand_note="high affinity"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   MOD_RES         42
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02634"
FT   MOD_RES         47
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02634"
SQ   SEQUENCE   79 AA;  8970 MW;  2272059DC925408F CRC64;
     MCAEKSPAEM KSIFQKYAAK EGDPDQLSKE ELKLLIQSEF PSLLKASSTL DNLFKELDKN
     GDGEVSYEEF EAFFKKLSQ
 
 
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