ABCGC_DICDI
ID ABCGC_DICDI Reviewed; 638 AA.
AC Q8T685; Q555D6;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=ABC transporter G family member 12;
DE AltName: Full=ABC transporter ABCG.12;
GN Name=abcG12; ORFNames=DDB_G0274115;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC Eye pigment precursor importer (TC 3.A.1.204) subfamily. {ECO:0000305}.
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DR EMBL; AF482387; AAL91494.1; -; Genomic_DNA.
DR EMBL; AAFI02000012; EAL69950.1; -; Genomic_DNA.
DR RefSeq; XP_644137.1; XM_639045.1.
DR AlphaFoldDB; Q8T685; -.
DR SMR; Q8T685; -.
DR STRING; 44689.DDB0191233; -.
DR PaxDb; Q8T685; -.
DR PRIDE; Q8T685; -.
DR EnsemblProtists; EAL69950; EAL69950; DDB_G0274115.
DR GeneID; 8619567; -.
DR KEGG; ddi:DDB_G0274115; -.
DR dictyBase; DDB_G0274115; abcG12.
DR eggNOG; KOG0061; Eukaryota.
DR HOGENOM; CLU_000604_57_8_1; -.
DR InParanoid; Q8T685; -.
DR OMA; NFMLQFP; -.
DR PhylomeDB; Q8T685; -.
DR Reactome; R-DDI-189451; Heme biosynthesis.
DR Reactome; R-DDI-189483; Heme degradation.
DR Reactome; R-DDI-917937; Iron uptake and transport.
DR Reactome; R-DDI-9753281; Paracetamol ADME.
DR PRO; PR:Q8T685; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IGC:dictyBase.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0030587; P:sorocarp development; IEA:UniProt.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01061; ABC2_membrane; 1.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..638
FT /note="ABC transporter G family member 12"
FT /id="PRO_0000391399"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 459..479
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 484..504
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 516..536
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 544..564
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 612..632
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 58..301
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 374..633
FT /note="ABC transmembrane type-2"
FT REGION 42..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 91..98
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 638 AA; 71288 MW; CC7BFFBFA8A79CA4 CRC64;
MELQTIPNNI SLANGDSKGV QLTFKNIVYK VDNKKYKKLV KKQEKAKKKN DTESSTGDMN
TGVSTTIEKE LTILNNVSGV IEKGELVALM GPSGSGKSTL LDILAQRKST GKITGQLLVN
GKEIGEAYKK YCSYVTQEDV LLQTSTVFET LKFYADLKLP GVSEIEKIKR VEQIIEDIGL
TKRTHSKIGG VLPGGILMKG LSGGEKRRVS IGCGLVTNPS LIFLDEPTSG LDSVAALQIM
KTLLNLTLKG VTVICSIHQP RPEIFALFNK VMVIIKGKMI YSGSNILEYF ESLGYPCPNN
TNPADFCLDS AVEIGEGERY TEICNQWQKI WENELLNEIE YPPVNVEKPK TASWGYQYWI
LLGRTWKDFL RNQGNFVARV GTAVVTGLLF GVCFAGLKET EADVQKILGT IFFLITGLNL
TPFAVISLFL SGRTLFNAER ASKIYHSFPY YMAMVTVETL IVFLVALINA AICYLFAHLR
WTAGHFFFAI MVYFFVHLLS DFMISTIANL TGTSDMTFAY GSGLSVIYML FAGFYVPTNE
LPKSFGWLHW VNPLFYSFVS LVVNQFEDLP LECTRPNIPV GNSTIQIPCQ FSNGNQVIEY
YGIDDWTRGS SFGVVVAWTV FFFWTSYLAL HFLNKEKR
