ID   S10A7_HORSE             Reviewed;         101 AA.
AC   Q14ST5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Protein S100-A7;
DE   AltName: Full=Psoriasin;
DE   AltName: Full=S100 calcium-binding protein A7;
GN   Name=s100A7;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Tongue;
RA   Bruhn O.;
RT   "Expression analysis of equine antimicrobial peptides.";
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Interacts with RANBP9. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Secreted {ECO:0000250}.
CC       Note=Secreted by a non-classical secretory pathway. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the S-100 family. {ECO:0000305}.
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DR   EMBL; AJ781506; CAH03717.1; -; mRNA.
DR   RefSeq; NP_001075349.1; NM_001081880.1.
DR   RefSeq; XP_014595182.1; XM_014739696.1.
DR   AlphaFoldDB; Q14ST5; -.
DR   SMR; Q14ST5; -.
DR   STRING; 9796.ENSECAP00000043895; -.
DR   PaxDb; Q14ST5; -.
DR   PeptideAtlas; Q14ST5; -.
DR   PRIDE; Q14ST5; -.
DR   GeneID; 100033976; -.
DR   KEGG; ecb:100033976; -.
DR   CTD; 6278; -.
DR   HOGENOM; CLU_138624_5_0_1; -.
DR   InParanoid; Q14ST5; -.
DR   OMA; FHNDTRH; -.
DR   OrthoDB; 1486203at2759; -.
DR   TreeFam; TF341148; -.
DR   Proteomes; UP000002281; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0048306; F:calcium-dependent protein binding; IBA:GO_Central.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   CDD; cd00213; S-100; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR034325; S-100_dom.
DR   InterPro; IPR001751; S100/CaBP7/8-like_CS.
DR   InterPro; IPR013787; S100_Ca-bd_sub.
DR   InterPro; IPR028477; S100A7.
DR   PANTHER; PTHR11639:SF67; PTHR11639:SF67; 1.
DR   Pfam; PF01023; S_100; 1.
DR   SMART; SM01394; S_100; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS00303; S100_CABP; 1.
PE   3: Inferred from homology;
KW   Acetylation; Calcium; Cytoplasm; Metal-binding; Reference proteome; Repeat;
KW   Secreted; Zinc.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P31151"
FT   CHAIN           2..101
FT                   /note="Protein S100-A7"
FT                   /id="PRO_0000320086"
FT   DOMAIN          8..42
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000305"
FT   DOMAIN          50..85
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         18
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         25
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         63
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_note="high affinity"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         65
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_note="high affinity"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         67
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_note="high affinity"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         69
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_note="high affinity"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         74
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_note="high affinity"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         87
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         91
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:P31151"
SQ   SEQUENCE   101 AA;  11332 MW;  3C4BC63A5E09EA9D CRC64;
     MSETEAEASV IGIIELFHKY TGRDDMIDKP GLLKMLQDNF PNFLAACDKK GTDYLANVFE
     KKDKNRDKKI DFSEFLSLLG DIATDYHKQS HGAPACSEGD Q