S10AA_CHICK
ID S10AA_CHICK Reviewed; 97 AA.
AC P27003;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Protein S100-A10;
DE AltName: Full=Calpactin I light chain;
DE AltName: Full=Calpactin-1 light chain;
DE AltName: Full=Cellular ligand of annexin II;
DE AltName: Full=S100 calcium-binding protein A10;
DE AltName: Full=p10 protein;
DE AltName: Full=p11;
GN Name=S100A10;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1831433; DOI=10.1016/0378-1119(91)90086-q;
RA Kube E., Weber K., Gerke V.;
RT "Primary structure of human, chicken, and Xenopus laevis p11, a cellular
RT ligand of the Src-kinase substrate, annexin II.";
RL Gene 102:255-259(1991).
CC -!- FUNCTION: Because S100A10 induces the dimerization of ANXA2/p36, it may
CC function as a regulator of protein phosphorylation in that the ANXA2
CC monomer is the preferred target (in vitro) of tyrosine-specific kinase.
CC {ECO:0000250}.
CC -!- SUBUNIT: Heterotetramer containing 2 light chains of S100A10/p11 and 2
CC heavy chains of ANXA2/p36.
CC -!- MISCELLANEOUS: Does not appear to bind calcium. Contains 2 ancestral
CC calcium site related to EF-hand domains that have lost their ability to
CC bind calcium.
CC -!- SIMILARITY: Belongs to the S-100 family. {ECO:0000305}.
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DR EMBL; M38592; AAA48690.1; -; mRNA.
DR PIR; JH0663; JH0663.
DR RefSeq; NP_990837.1; NM_205506.2.
DR RefSeq; XP_015135488.1; XM_015280002.1.
DR AlphaFoldDB; P27003; -.
DR SMR; P27003; -.
DR STRING; 9031.ENSGALP00000041652; -.
DR Ensembl; ENSGALT00000042661; ENSGALP00000041652; ENSGALG00000028774.
DR GeneID; 396506; -.
DR KEGG; gga:396506; -.
DR CTD; 6281; -.
DR VEuPathDB; HostDB:geneid_396506; -.
DR VEuPathDB; HostDB:LOC121107546; -.
DR eggNOG; ENOG502S6TB; Eukaryota.
DR GeneTree; ENSGT00940000154197; -.
DR HOGENOM; CLU_214116_0_0_1; -.
DR InParanoid; P27003; -.
DR OMA; SEMEHAP; -.
DR OrthoDB; 1508691at2759; -.
DR PhylomeDB; P27003; -.
DR PRO; PR:P27003; -.
DR Proteomes; UP000000539; Chromosome 25.
DR Bgee; ENSGALG00000028774; Expressed in granulocyte and 13 other tissues.
DR ExpressionAtlas; P27003; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0048306; F:calcium-dependent protein binding; IBA:GO_Central.
DR CDD; cd05024; S-100A10; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR028476; S100-A10.
DR InterPro; IPR001751; S100/CaBP7/8-like_CS.
DR InterPro; IPR013787; S100_Ca-bd_sub.
DR PANTHER; PTHR11639:SF74; PTHR11639:SF74; 1.
DR Pfam; PF01023; S_100; 1.
DR SMART; SM01394; S_100; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS00303; S100_CABP; 1.
PE 3: Inferred from homology;
KW Reference proteome; Repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..97
FT /note="Protein S100-A10"
FT /id="PRO_0000144007"
FT DOMAIN 47..82
FT /note="EF-hand"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REGION 60..71
FT /note="Ancestral calcium site"
SQ SEQUENCE 97 AA; 11290 MW; 4CF79C4F856971AB CRC64;
MPSQMEHAME TLMFTFHKYA GDKNYLSKED LRALMEKEFP GFLENQRDPM ALDKIMKDLD
QCRDGKVGFQ SFFSLVAGLT IACNDYFVVH MKQKGRK
