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S10AA_PIG
ID   S10AA_PIG               Reviewed;          96 AA.
AC   P04163;
DT   01-NOV-1986, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 2.
DT   25-MAY-2022, entry version 128.
DE   RecName: Full=Protein S100-A10;
DE   AltName: Full=Calpactin I light chain;
DE   AltName: Full=Calpactin-1 light chain;
DE   AltName: Full=Cellular ligand of annexin II;
DE   AltName: Full=S100 calcium-binding protein A10;
DE   AltName: Full=p10 protein;
DE   AltName: Full=p11;
GN   Name=S100A10;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   PROTEIN SEQUENCE OF 2-96.
RC   TISSUE=Intestinal epithelium;
RX   PubMed=2998764; DOI=10.1002/j.1460-2075.1985.tb04023.x;
RA   Gerke V., Weber K.;
RT   "The regulatory chain in the p36-kd substrate complex of viral tyrosine-
RT   specific protein kinases is related in sequence to the S-100 protein of
RT   glial cells.";
RL   EMBO J. 4:2917-2920(1985).
CC   -!- FUNCTION: Because S100A10 induces the dimerization of ANXA2/p36, it may
CC       function as a regulator of protein phosphorylation in that the ANXA2
CC       monomer is the preferred target (in vitro) of tyrosine-specific kinase.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Heterotetramer containing 2 light chains of S100A10/p11 and 2
CC       heavy chains of ANXA2/p36 (By similarity). Interacts with SCN10A (By
CC       similarity). Interacts with TASOR (By similarity).
CC       {ECO:0000250|UniProtKB:P05943, ECO:0000250|UniProtKB:P08207,
CC       ECO:0000250|UniProtKB:P60903}.
CC   -!- MISCELLANEOUS: Does not appear to bind calcium. Contains 2 ancestral
CC       calcium site related to EF-hand domains that have lost their ability to
CC       bind calcium.
CC   -!- SIMILARITY: Belongs to the S-100 family. {ECO:0000305}.
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DR   PIR; A03079; LUPG10.
DR   AlphaFoldDB; P04163; -.
DR   SMR; P04163; -.
DR   IntAct; P04163; 1.
DR   STRING; 9823.ENSSSCP00000007051; -.
DR   PaxDb; P04163; -.
DR   PeptideAtlas; P04163; -.
DR   PRIDE; P04163; -.
DR   eggNOG; ENOG502S6TB; Eukaryota.
DR   HOGENOM; CLU_138624_2_1_1; -.
DR   InParanoid; P04163; -.
DR   OMA; SEMEHAP; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   Genevisible; P04163; SS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0048306; F:calcium-dependent protein binding; IBA:GO_Central.
DR   GO; GO:0044325; F:transmembrane transporter binding; IBA:GO_Central.
DR   CDD; cd05024; S-100A10; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR028476; S100-A10.
DR   InterPro; IPR001751; S100/CaBP7/8-like_CS.
DR   InterPro; IPR013787; S100_Ca-bd_sub.
DR   PANTHER; PTHR11639:SF74; PTHR11639:SF74; 1.
DR   Pfam; PF01023; S_100; 1.
DR   SMART; SM01394; S_100; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00303; S100_CABP; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Direct protein sequencing; Isopeptide bond;
KW   Reference proteome; Ubl conjugation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:2998764"
FT   CHAIN           2..96
FT                   /note="Protein S100-A10"
FT                   /id="PRO_0000144005"
FT   REGION          60..71
FT                   /note="Ancestral calcium site"
FT   MOD_RES         23
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P60903"
FT   MOD_RES         28
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P60903"
FT   MOD_RES         37
FT                   /note="N6-acetyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:P60903"
FT   MOD_RES         54
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P60903"
FT   MOD_RES         57
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P60903"
FT   CROSSLNK        37
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2); alternate"
FT                   /evidence="ECO:0000250|UniProtKB:P60903"
SQ   SEQUENCE   96 AA;  11075 MW;  AE03A6E7DD7A8D65 CRC64;
     MPSQMEHAME TMMFTFHKFA GDKGYLTKED LRVLMEKEFP GFLENQKDPL AVDKIMKDLD
     QCRDGKVGFQ SFFSLIAGLT IACNDYFVVH MKQKGK
 
 
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