BEGIN_SHEEP
ID BEGIN_SHEEP Reviewed; 653 AA.
AC Q6R6L0; Q6R6L1; Q6R6L2; Q6R6L3;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=Brain-enriched guanylate kinase-associated protein;
GN Name=BEGAIN;
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4).
RA Smit M.A., Tordoir X., Gyapay G., Cockett N.E., Georges M., Charlier C.;
RT "BEGAIN: a novel imprinted gene that generates tissue-specific, paternally
RT expressed transcripts using alternate promoters.";
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May sustain the structure of the postsynaptic density (PSD).
CC -!- SUBUNIT: Interacts with DLG4 and DLGAP1 and forms a ternary complex.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1; Synonyms=BEGAIN-2B;
CC IsoId=Q6R6L0-1; Sequence=Displayed;
CC Name=2; Synonyms=BEGAIN-2A;
CC IsoId=Q6R6L0-2; Sequence=VSP_012586;
CC Name=3; Synonyms=BEGAIN-1B;
CC IsoId=Q6R6L0-3; Sequence=VSP_012585;
CC Name=4; Synonyms=BEGAIN-1A;
CC IsoId=Q6R6L0-4; Sequence=VSP_012585, VSP_012586;
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DR EMBL; AY509922; AAR98700.1; -; mRNA.
DR EMBL; AY509923; AAR98701.1; -; mRNA.
DR EMBL; AY509924; AAR98702.1; -; mRNA.
DR EMBL; AY509925; AAR98703.1; -; mRNA.
DR RefSeq; NP_001009766.1; NM_001009766.1. [Q6R6L0-1]
DR AlphaFoldDB; Q6R6L0; -.
DR SMR; Q6R6L0; -.
DR GeneID; 443287; -.
DR KEGG; oas:443287; -.
DR CTD; 57596; -.
DR eggNOG; ENOG502QUGW; Eukaryota.
DR OrthoDB; 443898at2759; -.
DR Proteomes; UP000002356; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR033584; BEGAIN.
DR InterPro; IPR043441; Tjap1/BEGAIN.
DR PANTHER; PTHR28664; PTHR28664; 1.
DR PANTHER; PTHR28664:SF2; PTHR28664:SF2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Membrane; Methylation; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..653
FT /note="Brain-enriched guanylate kinase-associated protein"
FT /id="PRO_0000064907"
FT REGION 241..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 587..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..328
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..608
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..653
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 186
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q68EF6"
FT MOD_RES 249
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BUH8"
FT MOD_RES 278
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q68EF6"
FT MOD_RES 295
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BUH8"
FT MOD_RES 314
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q68EF6"
FT MOD_RES 400
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BUH8"
FT MOD_RES 427
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BUH8"
FT MOD_RES 435
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q68EF6"
FT MOD_RES 523
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BUH8"
FT MOD_RES 533
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q68EF6"
FT MOD_RES 535
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q68EF6"
FT MOD_RES 558
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BUH8"
FT MOD_RES 560
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BUH8"
FT MOD_RES 564
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BUH8"
FT MOD_RES 613
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BUH8"
FT MOD_RES 623
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BUH8"
FT VAR_SEQ 1..14
FT /note="MWTGGRRPGRLRRA -> MGSHQSSQ (in isoform 3 and isoform
FT 4)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_012585"
FT VAR_SEQ 24..53
FT /note="Missing (in isoform 2 and isoform 4)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_012586"
SQ SEQUENCE 653 AA; 70854 MW; 99FF1A913C04EB7A CRC64;
MWTGGRRPGR LRRAASAADM EKLRLRSAWV PSCLGQSRNL QGRRARSSPS LWDSSLQEQK
GELRKRLSYT THRLEKLENE FDSTRHFLEI ELRRAQEELE KVTEKLRRIQ SNYMALQRIN
QELEDKLFRM GQHYEEEKRA LSHEIVALNS HLLEAKVTID KLSEDNELYR KDCSLAAQLL
QCSQAYGRGR KMAELPAEFQ ERMNLHAEKP GCSLPAPPRR PAYADSVPPC VLAKVLEKPD
PGSLSSHLSE ASAQDLGFPE GLEKPGSRPP YKGDIYCSDT ALYCPEARHQ DRRPSVEGPG
SDVGFLQAQN STDSTAEEEE EEEEDTEAGA AAYPASYRHE AFGGYAASLP TSSSYSSFSA
ASEEKEHAQA STLTASQQAI YLNSRDELFG RKPAAAYGSS PRYAAAAAAV AAPLEAAMAP
GFPRTVSPFP GEPFRFPLSP GPQPALMPPN LWNLRAKPGS ARLVAGAGRG QWRPLSVDDI
GAYPFPAAAA APAPSLASPG GGFNDRYFGA RGGPGDNAEG RASPLYASYK ADSFSEGDDL
SQGHLVEPRY LRAAGDLSLS PGHSADPLPS YAASEGDRER LGVQLLGASG SPEPELSLRS
SRDSLEPSSM EASPEMHPGA RLSPQPAFPR AGSSGLSRKD SLTKAQLYGT LLN
