ID   S10AA_XENLA             Reviewed;          96 AA.
AC   P27004;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Protein S100-A10;
DE   AltName: Full=Calpactin I light chain;
DE   AltName: Full=Calpactin-1 light chain;
DE   AltName: Full=Cellular ligand of annexin II;
DE   AltName: Full=S100 calcium-binding protein A10;
DE   AltName: Full=p10 protein;
DE   AltName: Full=p11;
GN   Name=s100a10;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1831433; DOI=10.1016/0378-1119(91)90086-q;
RA   Kube E., Weber K., Gerke V.;
RT   "Primary structure of human, chicken, and Xenopus laevis p11, a cellular
RT   ligand of the Src-kinase substrate, annexin II.";
RL   Gene 102:255-259(1991).
CC   -!- FUNCTION: Because p10 induces the dimerization of annexin II (p36), it
CC       may function as a regulator of protein phosphorylation in that the p36
CC       monomer is the preferred target (in vitro) of tyrosine-specific kinase.
CC   -!- SUBUNIT: Tetramer of 2 light chains (p10) and 2 heavy chains (annexin
CC       II).
CC   -!- MISCELLANEOUS: Does not appear to bind calcium. Contains 2 ancestral
CC       calcium site related to EF-hand domains that have lost their ability to
CC       bind calcium.
CC   -!- SIMILARITY: Belongs to the S-100 family. {ECO:0000305}.
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DR   EMBL; M38593; AAA49676.1; -; mRNA.
DR   PIR; JH0664; JH0664.
DR   RefSeq; NP_001079240.1; NM_001085771.1.
DR   AlphaFoldDB; P27004; -.
DR   SMR; P27004; -.
DR   GeneID; 378505; -.
DR   KEGG; xla:378505; -.
DR   CTD; 378505; -.
DR   Xenbase; XB-GENE-6254353; s100a10.L.
DR   OrthoDB; 1508691at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 378505; Expressed in internal ear and 17 other tissues.
DR   CDD; cd05024; S-100A10; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR028476; S100-A10.
DR   InterPro; IPR013787; S100_Ca-bd_sub.
DR   PANTHER; PTHR11639:SF74; PTHR11639:SF74; 1.
DR   Pfam; PF01023; S_100; 1.
DR   SMART; SM01394; S_100; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..96
FT                   /note="Protein S100-A10"
FT                   /id="PRO_0000144008"
FT   REGION          62..73
FT                   /note="Ancestral calcium site"
SQ   SEQUENCE   96 AA;  11329 MW;  93F5F5BB925313B0 CRC64;
     MVAPSELEHS MEKMLLTFHK FAGEKNYMNR DDLQKLLDSE FSEFLKNQND PMTVDKIMKD
     LDDCRKGQVN FRSYCSLIAG LLIACNEYYV KHMKKR