ID   S10AE_BOVIN             Reviewed;         104 AA.
AC   Q3MHP3;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Protein S100-A14;
DE   AltName: Full=S100 calcium-binding protein A14;
GN   Name=S100A14;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Modulates P53/TP53 protein levels, and thereby plays a role
CC       in the regulation of cell survival and apoptosis. Depending on the
CC       context, it can promote cell proliferation or apoptosis. Plays a role
CC       in the regulation of cell migration by modulating the levels of MMP2, a
CC       matrix protease that is under transcriptional control of P53/TP53. Does
CC       not bind calcium (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Interacts with AGER (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the S-100 family. {ECO:0000305}.
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DR   EMBL; BC105161; AAI05162.1; -; mRNA.
DR   RefSeq; NP_001073102.1; NM_001079634.2.
DR   RefSeq; XP_005203819.1; XM_005203762.1.
DR   AlphaFoldDB; Q3MHP3; -.
DR   SMR; Q3MHP3; -.
DR   STRING; 9913.ENSBTAP00000028498; -.
DR   PaxDb; Q3MHP3; -.
DR   PeptideAtlas; Q3MHP3; -.
DR   Ensembl; ENSBTAT00000028498; ENSBTAP00000028498; ENSBTAG00000021377.
DR   GeneID; 618250; -.
DR   KEGG; bta:618250; -.
DR   CTD; 57402; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021377; -.
DR   VGNC; VGNC:34240; S100A14.
DR   eggNOG; ENOG502SB9V; Eukaryota.
DR   GeneTree; ENSGT00940000161706; -.
DR   HOGENOM; CLU_138624_3_0_1; -.
DR   InParanoid; Q3MHP3; -.
DR   OMA; EKIECLG; -.
DR   OrthoDB; 1506806at2759; -.
DR   TreeFam; TF332727; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000021377; Expressed in surface of tongue and 103 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0048306; F:calcium-dependent protein binding; IBA:GO_Central.
DR   GO; GO:0042379; F:chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
DR   GO; GO:0071624; P:positive regulation of granulocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0090026; P:positive regulation of monocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0032496; P:response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0034142; P:toll-like receptor 4 signaling pathway; IBA:GO_Central.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR013787; S100_Ca-bd_sub.
DR   InterPro; IPR028493; S100A14.
DR   PANTHER; PTHR11639:SF4; PTHR11639:SF4; 1.
DR   Pfam; PF01023; S_100; 1.
DR   SMART; SM01394; S_100; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Cytoplasm; Reference proteome.
FT   CHAIN           1..104
FT                   /note="Protein S100-A14"
FT                   /id="PRO_0000236023"
FT   DOMAIN          27..61
FT                   /note="EF-hand"
SQ   SEQUENCE   104 AA;  11410 MW;  D8BB697ED132DFCE CRC64;
     MGQCRSANAE DAQELSDVER AIETLIKNFH QYSVEGGKET LTPSELRDLV TQQLPHLMPS
     NCGLEEKIAN LGNCNDSKLE FGSFWELIGE AAKSVKLENA VQGS