S10I_ICTPU
ID S10I_ICTPU Reviewed; 92 AA.
AC Q91061;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Ictacalcin;
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Olfactory epithelium;
RX PubMed=8883937; DOI=10.1016/0169-328x(96)00069-1;
RA Porta A.R., Bettini E., Buiakova O.I., Baker H., Danho W., Margolis F.L.;
RT "Molecular cloning of ictacalcin: a novel calcium-binding protein from the
RT channel catfish, Ictalurus punctatus.";
RL Brain Res. Mol. Brain Res. 41:81-89(1996).
CC -!- FUNCTION: Plays an important role in catfish calcium homeostasis.
CC -!- TISSUE SPECIFICITY: Abundant in epithelial cells of olfactory rosette,
CC barbel, skin and gill but not brain or muscle.
CC -!- SIMILARITY: Belongs to the S-100 family. {ECO:0000305}.
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DR EMBL; U33273; AAB52610.1; -; mRNA.
DR RefSeq; NP_001187203.1; NM_001200274.1.
DR RefSeq; XP_017323574.1; XM_017468085.1.
DR AlphaFoldDB; Q91061; -.
DR SMR; Q91061; -.
DR STRING; 7998.ENSIPUP00000004927; -.
DR GeneID; 100305037; -.
DR GeneID; 108265573; -.
DR KEGG; ipu:100305037; -.
DR KEGG; ipu:108265573; -.
DR OrthoDB; 1560865at2759; -.
DR Proteomes; UP000221080; Chromosome 1.
DR GO; GO:0005509; F:calcium ion binding; IDA:AgBase.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR CDD; cd00213; S-100; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR034325; S-100_dom.
DR InterPro; IPR001751; S100/CaBP7/8-like_CS.
DR InterPro; IPR013787; S100_Ca-bd_sub.
DR Pfam; PF00036; EF-hand_1; 1.
DR Pfam; PF01023; S_100; 1.
DR SMART; SM00054; EFh; 1.
DR SMART; SM01394; S_100; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS00303; S100_CABP; 1.
PE 2: Evidence at transcript level;
KW Calcium; Metal-binding; Repeat.
FT CHAIN 1..92
FT /note="Ictacalcin"
FT /id="PRO_0000144034"
FT DOMAIN 12..47
FT /note="EF-hand 1"
FT /evidence="ECO:0000305"
FT DOMAIN 49..84
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 27
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /ligand_note="low affinity"
FT /evidence="ECO:0000305"
FT BINDING 32
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /ligand_note="low affinity"
FT /evidence="ECO:0000305"
FT BINDING 62
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 64
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 66
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 73
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 92 AA; 10022 MW; DBFE786B7F921C58 CRC64;
MSDLQKGMAL LISTFHKYSG KEGDKCTLTK GELKDLLTKE LGGAFGNCSD QATLDKIFKD
LDTNADGVVD FQEYATMVAC TTMLCNKSLS KK
