S115A_MOUSE
ID S115A_MOUSE Reviewed; 108 AA.
AC Q6S5I3;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Protein S100-A15A;
DE AltName: Full=Protein S100-A7A;
DE AltName: Full=S100 calcium-binding protein A15A;
DE AltName: Full=S100 calcium-binding protein A7A;
GN Name=S100a15a; Synonyms=S100a15, S100a7, S100a7a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=C57BL/6xC3H; TISSUE=Skin;
RX PubMed=16528363; DOI=10.1038/sj.jid.5700210;
RA Wolf R., Voscopoulos C.J., FitzGerald P.C., Goldsmith P., Cataisson C.,
RA Gunsior M., Walz M., Ruzicka T., Yuspa S.H.;
RT "The mouse S100A15 ortholog parallels genomic organization, structure, gene
RT expression, and protein-processing pattern of the human S100A7/A15
RT subfamily during epidermal maturation.";
RL J. Invest. Dermatol. 126:1600-1608(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=CD-1;
RA Webb M.B., Murphy L.C., Emberley E.D., Myal Y., Shiu R.P., Watson P.H.;
RT "The murine ortholog of human S100A7 (psoriasin).";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the S-100 family. {ECO:0000305}.
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DR EMBL; AY465109; AAR32782.1; -; mRNA.
DR EMBL; AY465110; AAR32783.1; -; Genomic_DNA.
DR EMBL; AY582964; AAS91715.1; -; mRNA.
DR EMBL; BC107307; AAI07308.1; -; mRNA.
DR EMBL; BC107308; AAI07309.1; -; mRNA.
DR CCDS; CCDS17541.1; -.
DR RefSeq; NP_955454.1; NM_199422.1.
DR RefSeq; XP_006501695.1; XM_006501632.3.
DR RefSeq; XP_006501696.1; XM_006501633.3.
DR RefSeq; XP_006501698.1; XM_006501635.3.
DR AlphaFoldDB; Q6S5I3; -.
DR SMR; Q6S5I3; -.
DR STRING; 10090.ENSMUSP00000078268; -.
DR PaxDb; Q6S5I3; -.
DR PRIDE; Q6S5I3; -.
DR ProteomicsDB; 255436; -.
DR DNASU; 381493; -.
DR Ensembl; ENSMUST00000079286; ENSMUSP00000078268; ENSMUSG00000063767.
DR GeneID; 381493; -.
DR KEGG; mmu:381493; -.
DR UCSC; uc008qdc.1; mouse.
DR CTD; 338324; -.
DR MGI; MGI:2687194; S100a7a.
DR VEuPathDB; HostDB:ENSMUSG00000063767; -.
DR eggNOG; ENOG502SXYF; Eukaryota.
DR GeneTree; ENSGT00910000144375; -.
DR HOGENOM; CLU_138624_5_0_1; -.
DR InParanoid; Q6S5I3; -.
DR OMA; FQIIHCF; -.
DR OrthoDB; 1486203at2759; -.
DR PhylomeDB; Q6S5I3; -.
DR TreeFam; TF341148; -.
DR BioGRID-ORCS; 381493; 0 hits in 71 CRISPR screens.
DR PRO; PR:Q6S5I3; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q6S5I3; protein.
DR Bgee; ENSMUSG00000063767; Expressed in esophagus and 50 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0005576; C:extracellular region; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0005509; F:calcium ion binding; ISO:MGI.
DR GO; GO:0048306; F:calcium-dependent protein binding; IBA:GO_Central.
DR GO; GO:0042056; F:chemoattractant activity; IDA:MGI.
DR GO; GO:0043621; F:protein self-association; ISO:MGI.
DR GO; GO:0050786; F:RAGE receptor binding; ISO:MGI.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IDA:MGI.
DR CDD; cd00213; S-100; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR034325; S-100_dom.
DR InterPro; IPR013787; S100_Ca-bd_sub.
DR InterPro; IPR028495; S100A15A.
DR PANTHER; PTHR11639:SF29; PTHR11639:SF29; 1.
DR Pfam; PF00036; EF-hand_1; 1.
DR Pfam; PF01023; S_100; 1.
DR SMART; SM00054; EFh; 1.
DR SMART; SM01394; S_100; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Calcium; Metal-binding; Reference proteome; Zinc.
FT CHAIN 1..108
FT /note="Protein S100-A15A"
FT /id="PRO_0000320087"
FT DOMAIN 53..88
FT /note="EF-hand"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 66
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 68
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 70
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 72
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 77
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 108 AA; 12870 MW; D9B9A13F7A50DBC0 CRC64;
MPDTPVEDSL FQIIHCFHHY AAREGDKETL SLEELKALLL DSVPRFMDTL GRRQPYYITE
LFRAADKNKD NQICFDEFLY ILGKLVKDYH LQFHRQLCAH YCTEHSLY
