S11IP_MOUSE
ID S11IP_MOUSE Reviewed; 1072 AA.
AC Q3TAA7; Q6P7J8; Q9DBT7;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Serine/threonine-protein kinase 11-interacting protein;
DE AltName: Full=LKB1-interacting protein 1;
GN Name=Stk11ip; Synonyms=Lip1, Lkb1ip;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Lung, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP INTERACTION WITH STK11/LKB1.
RX PubMed=11741830; DOI=10.1093/hmg/10.25.2869;
RA Smith D.P., Rayter S.I., Niederlander C., Spicer J., Jones C.M.,
RA Ashworth A.;
RT "LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers
RT syndrome kinase LKB1.";
RL Hum. Mol. Genet. 10:2869-2877(2001).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-388; SER-390; SER-393;
RP SER-761 AND SER-763, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Kidney, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May regulate STK11/LKB1 function by controlling its
CC subcellular localization. {ECO:0000250}.
CC -!- SUBUNIT: Found in a ternary complex composed of STK11/LKB1, STK11IP and
CC SMAD4 (By similarity). Interacts with SMAD4 (By similarity). Interacts
CC with STK11/LKB1. {ECO:0000250, ECO:0000269|PubMed:11741830}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Some cells show
CC granular or punctuate expression. Colocalizes with STK11/LKB1 and SMAD4
CC in granular or punctuate structures (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the STK11IP family. {ECO:0000305}.
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DR EMBL; AK004757; BAB23538.1; -; mRNA.
DR EMBL; AK156122; BAE33593.1; -; mRNA.
DR EMBL; AK171989; BAE42762.1; -; mRNA.
DR EMBL; BC061635; AAH61635.1; -; mRNA.
DR CCDS; CCDS15079.1; -.
DR RefSeq; NP_082162.3; NM_027886.3.
DR AlphaFoldDB; Q3TAA7; -.
DR BioGRID; 214885; 1.
DR IntAct; Q3TAA7; 1.
DR MINT; Q3TAA7; -.
DR STRING; 10090.ENSMUSP00000027414; -.
DR iPTMnet; Q3TAA7; -.
DR PhosphoSitePlus; Q3TAA7; -.
DR EPD; Q3TAA7; -.
DR jPOST; Q3TAA7; -.
DR MaxQB; Q3TAA7; -.
DR PaxDb; Q3TAA7; -.
DR PeptideAtlas; Q3TAA7; -.
DR PRIDE; Q3TAA7; -.
DR ProteomicsDB; 253332; -.
DR Antibodypedia; 34344; 144 antibodies from 26 providers.
DR DNASU; 71728; -.
DR Ensembl; ENSMUST00000027414; ENSMUSP00000027414; ENSMUSG00000026213.
DR Ensembl; ENSMUST00000113553; ENSMUSP00000109182; ENSMUSG00000026213.
DR GeneID; 71728; -.
DR KEGG; mmu:71728; -.
DR UCSC; uc007bpt.2; mouse.
DR CTD; 114790; -.
DR MGI; MGI:1918978; Stk11ip.
DR VEuPathDB; HostDB:ENSMUSG00000026213; -.
DR eggNOG; KOG1859; Eukaryota.
DR GeneTree; ENSGT00940000158471; -.
DR HOGENOM; CLU_008018_0_0_1; -.
DR InParanoid; Q3TAA7; -.
DR OMA; VCDPPGH; -.
DR OrthoDB; 1041637at2759; -.
DR PhylomeDB; Q3TAA7; -.
DR TreeFam; TF326448; -.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 71728; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Stk11ip; mouse.
DR PRO; PR:Q3TAA7; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q3TAA7; protein.
DR Bgee; ENSMUSG00000026213; Expressed in retinal neural layer and 188 other tissues.
DR Genevisible; Q3TAA7; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0019901; F:protein kinase binding; ISO:MGI.
DR GO; GO:0008104; P:protein localization; ISO:MGI.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR031782; LIP1_N.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF15904; LIP1; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Leucine-rich repeat; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..1072
FT /note="Serine/threonine-protein kinase 11-interacting
FT protein"
FT /id="PRO_0000317463"
FT REPEAT 109..130
FT /note="LRR 1"
FT REPEAT 132..152
FT /note="LRR 2"
FT REPEAT 164..185
FT /note="LRR 3"
FT REPEAT 187..209
FT /note="LRR 4"
FT REPEAT 210..231
FT /note="LRR 5"
FT REPEAT 233..254
FT /note="LRR 6"
FT REPEAT 255..276
FT /note="LRR 7"
FT REPEAT 280..301
FT /note="LRR 8"
FT REGION 333..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 441..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 967..993
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..492
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..521
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..762
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 973..993
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 388
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 390
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 393
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 757
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N1F8"
FT MOD_RES 761
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 763
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 57
FT /note="T -> A (in Ref. 1; BAB23538)"
FT /evidence="ECO:0000305"
FT CONFLICT 210
FT /note="E -> D (in Ref. 2; AAH61635)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1072 AA; 118005 MW; D0CD7C67508B6F5F CRC64;
MTTAPRDSVV WKLAGLLRES GDAVLSGCST LSLLTATLQQ LNRVFELYLG PWGPGQTGFV
ALPSHPADSP VILQLQFLFD VLQKTLSLKL VHIPGVGLPG PIKIFPFKSL RQLELRGVPI
HSLCGLRGIY SQLESLVCNR SIQALEELLS ACGGDLCSAL PWLALLSADF SYNALRSLDS
SLRLLSALRF LNLSHNHLQD CKGFLMDLCE LYHLDISYNH LRLVPRVGPS GAALGTLILR
ANELRSLQGL EQLKNLRHLD VAYNLLEGHT ELAPLWLLAE LRKLYLEGNP LWFHPAHRAA
TAQYLSPRAR DAAHGFLLDG KVLSLKDLQQ TSDSSGLGPV IQPLSWPVGS TTETSGGPEL
SDSLSSGGIV AQAPLRKVKS RVRVRRASIS EPSDTDPELR TLDPSPAGWF VQQHRELELL
ASFRERFGCD WLQYRSHLET MGSSPLSTTK TPALSTPPLD VQNLETVCSP PAIEDDTKES
PEKVSEEGRV EPEPQEEERE EQDKEEGSRE DLEEEEEQEQ KAVEAELCRP MLVCPLQGLG
GVQGKECFLR VTSAHLFEVE LQAARTLERL ELQSLVAAEL ESETETQGEP VSEGSGPFPG
APVLVLRFSY ICPDRQLRRY AVLEPEAREA VQELLAVLTP FTSVKEQQPG ANKDPQGARF
QCLRCSCEFK PEESRLGLES DEGWKPLFQN TESPVVCPNC GSDHVVLLAV SGEVPNREQN
QEEQSADSAC DLADHGGCPS RPDGIPPQTS ISHDRSSWSL SPSPGCSGFR SVDHRLRLFL
DVEVFSDSEE EFQCCIKVPV VLAGHTEEFP CLVVVSNHML YLLKVLGAIC GPPASWLQPT
LAIALQDLSG MELGLAGQSL RLEWAAGTGS CVLLPRDARQ CRAFLEELTG VLQSLPRTQR
NCISATEEEV TPQHRLWPLL GKDPSAEVPQ FFYLRAFLAE GSSTCPVSLL LTLSTLYLLD
EDPGGSHAES PLPVVSDETS EQPASLGPGP SLQVREQQPL SCLSSVQLYR TSPLDLRLIF
YDEVSRLESF WALHVVCGEQ LTALLAWIRE PWEELFSIGL RTVTQEALDL DR
