S12A8_HUMAN
ID S12A8_HUMAN Reviewed; 714 AA.
AC A0AV02; C9JJJ2; Q68D04; Q6I9Z2; Q6P4C0; Q7Z3A6; Q86WK0; Q8NFX9; Q8WUI3;
AC Q96RF9; Q9H5P9;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 27-MAY-2015, sequence version 4.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Solute carrier family 12 member 8;
DE AltName: Full=Cation-chloride cotransporter 9;
GN Name=SLC12A8; Synonyms=CCC9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUSCEPTIBILITY TO PSORIASIS,
RP FUNCTION, TISSUE SPECIFICITY, AND VARIANTS CYS-181 AND VAL-281.
RX PubMed=11863360; DOI=10.1006/geno.2002.6720;
RA Hewett D., Samuelsson L., Polding J., Enlund F., Smart D., Cantone K.,
RA See C.G., Chadha S., Inerot A., Enerback C., Montgomery D.,
RA Christodolou C., Robinson P., Matthews P., Plumpton M., Wahlstrom J.,
RA Swanbeck G., Martinsson T., Roses A., Riley J., Purvis I.;
RT "Identification of a psoriasis susceptibility candidate gene by linkage
RT disequilibrium mapping with a localized single nucleotide polymorphism
RT map.";
RL Genomics 79:305-314(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS VAL-281 AND GLN-664.
RA Mount D.B.;
RT "Characterization of Homo sapiens CCC9, a novel member of the cation-
RT chloride cotransporter gene family.";
RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
RC TISSUE=Lung;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Endometrial adenocarcinoma, and Salivary gland;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), AND VARIANT
RP VAL-281.
RC TISSUE=Colon, and Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 407-714 (ISOFORM 1).
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP SUSCEPTIBILITY TO PSORIASIS.
RX PubMed=16297188; DOI=10.1111/j.0022-202x.2005.23847.x;
RA Hueffmeier U., Lascorz J., Traupe H., Boehm B., Schuermeier-Horst F.,
RA Staender M., Kelsch R., Baumann C., Kuester W., Burkhardt H., Reis A.;
RT "Systematic linkage disequilibrium analysis of SLC12A8 at PSORS5 confirms a
RT role in susceptibility to psoriasis vulgaris.";
RL J. Invest. Dermatol. 125:906-912(2005).
CC -!- FUNCTION: Cation/chloride cotransporter that may play a role in the
CC control of keratinocyte proliferation. {ECO:0000269|PubMed:11863360}.
CC -!- INTERACTION:
CC A0AV02; P26367: PAX6; NbExp=3; IntAct=EBI-11737524, EBI-747278;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=A0AV02-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A0AV02-2; Sequence=VSP_028330;
CC Name=3;
CC IsoId=A0AV02-3; Sequence=VSP_028329, VSP_028331;
CC Name=4;
CC IsoId=A0AV02-4; Sequence=VSP_028328, VSP_028332;
CC Name=5;
CC IsoId=A0AV02-5; Sequence=VSP_028327;
CC -!- TISSUE SPECIFICITY: Ubiquitous with very low level in normal skin.
CC {ECO:0000269|PubMed:11863360}.
CC -!- DISEASE: Note=SLC12A8 has been identified as a possible susceptibility
CC gene for psoriasis mapped to chromosome 3q21 (PSORS5).
CC -!- SIMILARITY: Belongs to the SLC12A transporter family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH20506.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH63528.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH63528.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAK94307.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAM73657.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAD97969.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF389851; AAK94307.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AF390442; AAM73657.1; ALT_INIT; mRNA.
DR EMBL; AF345197; AAO49174.1; -; mRNA.
DR EMBL; AK026841; BAB15571.1; -; mRNA.
DR EMBL; BX538023; CAD97969.1; ALT_INIT; mRNA.
DR EMBL; CR749632; CAH18426.1; -; mRNA.
DR EMBL; AC055752; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC108688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC117488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC020506; AAH20506.1; ALT_INIT; mRNA.
DR EMBL; BC063528; AAH63528.1; ALT_SEQ; mRNA.
DR EMBL; BC126158; AAI26159.1; -; mRNA.
DR EMBL; BC126160; AAI26161.1; -; mRNA.
DR EMBL; CR457363; CAG33644.1; -; mRNA.
DR CCDS; CCDS43143.1; -. [A0AV02-1]
DR RefSeq; NP_001182412.1; NM_001195483.1. [A0AV02-1]
DR RefSeq; NP_078904.3; NM_024628.5. [A0AV02-1]
DR AlphaFoldDB; A0AV02; -.
DR SMR; A0AV02; -.
DR BioGRID; 124140; 14.
DR IntAct; A0AV02; 4.
DR MINT; A0AV02; -.
DR STRING; 9606.ENSP00000377112; -.
DR TCDB; 2.A.30.1.7; the cation-chloride cotransporter (ccc) family.
DR GlyGen; A0AV02; 1 site.
DR iPTMnet; A0AV02; -.
DR PhosphoSitePlus; A0AV02; -.
DR BioMuta; SLC12A8; -.
DR EPD; A0AV02; -.
DR jPOST; A0AV02; -.
DR MassIVE; A0AV02; -.
DR MaxQB; A0AV02; -.
DR PaxDb; A0AV02; -.
DR PeptideAtlas; A0AV02; -.
DR PRIDE; A0AV02; -.
DR ProteomicsDB; 10; -. [A0AV02-2]
DR ProteomicsDB; 11; -. [A0AV02-3]
DR ProteomicsDB; 12; -. [A0AV02-4]
DR ProteomicsDB; 13; -. [A0AV02-5]
DR ProteomicsDB; 9; -. [A0AV02-1]
DR TopDownProteomics; A0AV02-3; -. [A0AV02-3]
DR TopDownProteomics; A0AV02-5; -. [A0AV02-5]
DR Antibodypedia; 33008; 39 antibodies from 17 providers.
DR DNASU; 84561; -.
DR Ensembl; ENST00000393469.8; ENSP00000377112.4; ENSG00000221955.11. [A0AV02-1]
DR Ensembl; ENST00000430155.6; ENSP00000415713.2; ENSG00000221955.11. [A0AV02-3]
DR Ensembl; ENST00000469902.6; ENSP00000418783.1; ENSG00000221955.11. [A0AV02-1]
DR GeneID; 84561; -.
DR KEGG; hsa:84561; -.
DR MANE-Select; ENST00000469902.6; ENSP00000418783.1; NM_024628.6; NP_078904.4.
DR UCSC; uc003eht.4; human. [A0AV02-1]
DR CTD; 84561; -.
DR DisGeNET; 84561; -.
DR GeneCards; SLC12A8; -.
DR HGNC; HGNC:15595; SLC12A8.
DR HPA; ENSG00000221955; Tissue enhanced (thyroid).
DR MIM; 611316; gene.
DR neXtProt; NX_A0AV02; -.
DR OpenTargets; ENSG00000221955; -.
DR PharmGKB; PA37991; -.
DR VEuPathDB; HostDB:ENSG00000221955; -.
DR eggNOG; KOG2083; Eukaryota.
DR GeneTree; ENSGT00940000160130; -.
DR HOGENOM; CLU_017440_1_1_1; -.
DR InParanoid; A0AV02; -.
DR OMA; WYSGFCN; -.
DR OrthoDB; 792706at2759; -.
DR TreeFam; TF313191; -.
DR PathwayCommons; A0AV02; -.
DR SignaLink; A0AV02; -.
DR BioGRID-ORCS; 84561; 9 hits in 1062 CRISPR screens.
DR ChiTaRS; SLC12A8; human.
DR GeneWiki; SLC12A8; -.
DR GenomeRNAi; 84561; -.
DR Pharos; A0AV02; Tbio.
DR PRO; PR:A0AV02; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; A0AV02; protein.
DR Bgee; ENSG00000221955; Expressed in right lobe of thyroid gland and 137 other tissues.
DR ExpressionAtlas; A0AV02; baseline and differential.
DR Genevisible; A0AV02; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IBA:GO_Central.
DR GO; GO:0006884; P:cell volume homeostasis; IBA:GO_Central.
DR GO; GO:0055064; P:chloride ion homeostasis; IBA:GO_Central.
DR GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
DR GO; GO:0055075; P:potassium ion homeostasis; IBA:GO_Central.
DR GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR030343; SLC12A8.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827; PTHR11827; 1.
DR PANTHER; PTHR11827:SF6; PTHR11827:SF6; 1.
DR Pfam; PF00324; AA_permease; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chloride; Glycoprotein; Ion transport; Membrane;
KW Potassium; Potassium transport; Reference proteome; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..714
FT /note="Solute carrier family 12 member 8"
FT /id="PRO_0000305287"
FT TRANSMEM 37..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..289
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..331
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 360..377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 383..403
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 593..616
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 622..643
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 471..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..498
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..549
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 221
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..406
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_028327"
FT VAR_SEQ 1..247
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028328"
FT VAR_SEQ 1..199
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_028329"
FT VAR_SEQ 1..17
FT /note="MTQMSQVQELFHEAAQQ -> MLPLERTITYRDMSSFIQVKNHFNVVNVTCV
FT SYRSTCFRDMRRFIL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_028330"
FT VAR_SEQ 200..245
FT /note="GSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVFFPAAT -> MR
FT RAAAGGLAVGQLPGEGPAGEEGAALGKAMRGGGCSPHSPSGCLS (in isoform
FT 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_028331"
FT VAR_SEQ 569..661
FT /note="DFFLKSRLQEQDVWRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVN
FT MGVAAIVYFYIGRASPGLHLGSASNFSFFRWMRSLLLPSCR -> G (in isoform
FT 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028332"
FT VARIANT 181
FT /note="R -> C (in dbSNP:rs2993631)"
FT /evidence="ECO:0000269|PubMed:11863360"
FT /id="VAR_035199"
FT VARIANT 266
FT /note="L -> P (in dbSNP:rs863642)"
FT /id="VAR_035200"
FT VARIANT 281
FT /note="I -> V (in dbSNP:rs621383)"
FT /evidence="ECO:0000269|PubMed:11863360,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT /id="VAR_062148"
FT VARIANT 541
FT /note="K -> R (in dbSNP:rs6773138)"
FT /id="VAR_035201"
FT VARIANT 664
FT /note="R -> Q (in dbSNP:rs2981482)"
FT /evidence="ECO:0000269|Ref.2"
FT /id="VAR_035202"
FT CONFLICT 111
FT /note="S -> P (in Ref. 4; CAH18426)"
FT /evidence="ECO:0000305"
FT CONFLICT 319
FT /note="S -> P (in Ref. 1; AAM73657)"
FT /evidence="ECO:0000305"
FT CONFLICT 433
FT /note="L -> P (in Ref. 6; CAG33644)"
FT /evidence="ECO:0000305"
FT CONFLICT 481
FT /note="E -> D (in Ref. 3; BAB15571)"
FT /evidence="ECO:0000305"
FT CONFLICT 512
FT /note="P -> L (in Ref. 4; CAH18426)"
FT /evidence="ECO:0000305"
FT CONFLICT 555
FT /note="L -> P (in Ref. 4; CAD97969)"
FT /evidence="ECO:0000305"
FT CONFLICT 698
FT /note="R -> H (in Ref. 2; AAO49174)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 714 AA; 78239 MW; CE7669E9758EF00D CRC64;
MTQMSQVQEL FHEAAQQDAL AQPQPWWKTQ LFMWEPVLFG TWDGVFTSCM INIFGVVLFL
RTGWLVGNTG VLLGMFLVSF VILVALVTVL SGIGVGERSS IGSGGVYSMI SSVLGGQTGG
TIGLLYVFGQ CVAGAMYITG FAESISDLLG LGNIWAVRGI SVAVLLALLG INLAGVKWII
RLQLLLLFLL AVSTLDFVVG SFTHLDPEHG FIGYSPELLQ NNTLPDYSPG ESFFTVFGVF
FPAATGVMAG FNMGGDLREP AASIPLGSLA AVGISWFLYI IFVFLLGAIC TREALRYDFL
IAEKVSLMGF LFLLGLYISS LASCMGGLYG APRILQCIAQ EKVIPALACL GQGKGPNKTP
VAAICLTSLV TMAFVFVGQV NVLAPIVTIN FMLTYVAVDY SYFSLSMCSC SLTPVPEPVL
REGAEGLHCS EHLLLEKAPS YGSEGPAQRV LEGTLLEFTK DMDQLLQLTR KLESSQPRQG
EGNRTPESQK RKSKKATKQT LQDSFLLDLK SPPSFPVEIS DRLPAASWEG QESCWNKQTS
KSEGTQPEGT YGEQLVPELC NQSESSGEDF FLKSRLQEQD VWRRSTSFYT HMCNPWVSLL
GAVGSLLIMF VIQWVYTLVN MGVAAIVYFY IGRASPGLHL GSASNFSFFR WMRSLLLPSC
RSLRSPQEQI ILAPSLAKVD MEMTQLTQEN ADFATRDRYH HSSLVNREQL MPHY
