ID   S12A8_XENLA             Reviewed;         721 AA.
AC   Q6A4L1;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Solute carrier family 12 member 8;
GN   Name=slc12a8;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Mount D.B.;
RT   "Sequence of the Xenopus ortholog of the SLC12A8 cation-chloride
RT   cotransporter.";
RL   Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cation/chloride cotransporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SLC12A transporter family. {ECO:0000305}.
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DR   EMBL; AF529219; AAQ09093.1; -; mRNA.
DR   RefSeq; NP_001086448.1; NM_001092979.1.
DR   AlphaFoldDB; Q6A4L1; -.
DR   SMR; Q6A4L1; -.
DR   MaxQB; Q6A4L1; -.
DR   PRIDE; Q6A4L1; -.
DR   GeneID; 446259; -.
DR   KEGG; xla:446259; -.
DR   CTD; 446259; -.
DR   Xenbase; XB-GENE-997782; slc12a8.L.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 446259; Expressed in stomach and 17 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015377; F:cation:chloride symporter activity; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR030343; SLC12A8.
DR   InterPro; IPR004842; SLC12A_fam.
DR   PANTHER; PTHR11827; PTHR11827; 1.
DR   PANTHER; PTHR11827:SF6; PTHR11827:SF6; 1.
DR   Pfam; PF00324; AA_permease; 1.
PE   2: Evidence at transcript level;
KW   Chloride; Ion transport; Membrane; Potassium; Potassium transport;
KW   Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..721
FT                   /note="Solute carrier family 12 member 8"
FT                   /id="PRO_0000305290"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        321..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        374..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        397..417
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        606..626
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        628..648
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          473..505
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          533..580
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        481..495
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        538..553
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   721 AA;  79406 MW;  7981E6A08B72F8A3 CRC64;
     MGMIEPNRSV LLNGSMNGSE NIKDLFHEDA QVSQLQSRPW WKIQLFVWEP VLFGTWDGVF
     TSCMINIFGV VLFLRTGWLV GNTGVLLGIV LVSFVILVAL VTVLSGIGVC ERCSIGSGGV
     YSMVSTVLGG KVGGTIGVLY IFGQCVAGAM YITGFAESIS DLLNLENMWV VRGISLAVLV
     GLLGINLAGV KWIIRLQLLL FLLLAVSTLD FVIGSFTHLD PENGFVGYSE ELLRNNTFPD
     YTPGESFFTV FGVFFPAATG VMVGFNMSGD LQRPSINIPL GSLAAIGTSW FLYVVFVFLL
     GAICTREFLR YEFMIAEKVS LVGGLFLLGL YISSLASCMG GLYGAPRILQ CIAQEKVIPA
     LSFLGRGKGP NKTPVAAIFI TGLLTMAFVF IGQVNVLAPI VTINFMLTYS AVDYSYFSVT
     MSYKMQHSPK KNGRPNSRVM SSTQPLILNK STSYGSNGTL LEFTKDMNQL FKPNHTEAPE
     STSSQEKDPK MFKFSKPRKP AKQTLQDSFQ LDLHQGPEHG LESRLLVTDL AENESQNSKA
     EITEDKNQGV DPTESDEPDS EEDVDIQQPT EEQKGDSTVA QKVPEFEIQE LSTSFYAKFC
     NHWVAFLGAI LSIVIMFVIQ WIYALVNLGV AIILYLYIGR VNPGLNPGAA ANFSFFAWIR
     QGARTLCRKP HPKEQFVVTP SLLSVGMETT QLTEENEDFA SRGRYHHSSI ITQGQFIDRY
     N