S12A9_DANRE
ID S12A9_DANRE Reviewed; 899 AA.
AC A2BFP5;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Solute carrier family 12 member 9;
GN Name=slc12a9; ORFNames=si:ch211-284e13.1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- FUNCTION: Seems to correspond to a subunit of a multimeric transport
CC system and thus, additional subunits may be required for its function.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family. {ECO:0000305}.
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DR EMBL; CT025690; CAM14083.1; -; Genomic_DNA.
DR EMBL; BX294181; CAM14083.1; JOINED; Genomic_DNA.
DR EMBL; BX294181; CAM14224.1; -; Genomic_DNA.
DR EMBL; CT025690; CAM14224.1; JOINED; Genomic_DNA.
DR RefSeq; NP_001122020.1; NM_001128548.1.
DR RefSeq; XP_005165422.1; XM_005165365.3.
DR RefSeq; XP_017211661.1; XM_017356172.1.
DR AlphaFoldDB; A2BFP5; -.
DR SMR; A2BFP5; -.
DR STRING; 7955.ENSDARP00000120278; -.
DR PaxDb; A2BFP5; -.
DR PeptideAtlas; A2BFP5; -.
DR Ensembl; ENSDART00000084917; ENSDARP00000079352; ENSDARG00000060366.
DR Ensembl; ENSDART00000139479; ENSDARP00000120278; ENSDARG00000060366.
DR GeneID; 793341; -.
DR KEGG; dre:793341; -.
DR CTD; 56996; -.
DR ZFIN; ZDB-GENE-050208-222; slc12a9.
DR eggNOG; KOG1288; Eukaryota.
DR GeneTree; ENSGT00940000159400; -.
DR HOGENOM; CLU_001883_3_0_1; -.
DR InParanoid; A2BFP5; -.
DR OMA; NAGLYVT; -.
DR OrthoDB; 515568at2759; -.
DR PhylomeDB; A2BFP5; -.
DR TreeFam; TF313191; -.
DR PRO; PR:A2BFP5; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 5.
DR Bgee; ENSDARG00000060366; Expressed in mesonephros and 22 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IBA:GO_Central.
DR GO; GO:0006884; P:cell volume homeostasis; IBA:GO_Central.
DR GO; GO:0055064; P:chloride ion homeostasis; IBA:GO_Central.
DR GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
DR GO; GO:0055075; P:potassium ion homeostasis; IBA:GO_Central.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR030345; SLC12A9.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827; PTHR11827; 1.
DR PANTHER; PTHR11827:SF98; PTHR11827:SF98; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 1.
PE 3: Inferred from homology;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..899
FT /note="Solute carrier family 12 member 9"
FT /id="PRO_0000331418"
FT TOPO_DOM 1..42
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..78
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 100..125
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 147..175
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 197..201
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..306
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..350
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 372..373
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 374..394
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 395..399
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 400..420
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 421
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 422..442
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 443..455
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 456..476
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 477..487
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 488..510
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 511..563
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 564..584
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 585..749
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 750..770
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 771..899
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 228
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 236
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 249
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 899 AA; 98476 MW; 505344603A3B808F CRC64;
MANEHSPLLV HGVYSMMGNA EDSRGGSAGT GEASNPKTDP RKLNTFFGVM VPTILSMFSI
VLFLRTGFVV GHAGLLHGLL MLFVAYFIIS LTILSICAIS TNGAVEGGGA YFMISRSLGP
EFGGSIGLMF YLAKVCACGV YVLGLVEAIM DVFGQDPGSS VAQGLRVLPQ GYWYTVLYSS
VVLLLCMLVC LVGAHIYAKA SFLILLVVTV SLISIIISPL IVSPQGFNIT HTYGNNHSVT
VSPSYTGFNS TTLKNNLGPR YSLDYSTNTM MSFATVFAVM FTSCTGIMAG ANMSGELKNP
SESIPKGTIM AVAYTFTVYV LLYLLLSSTC DRSLLLNDYA VFQRVNVWPP FVTIGVYCAS
LSAAMCSMIG ASRILHALAL DQLFGLPLAP AAVTSSSGNP WVSVLYTWAL VQCTLFAGQL
NVIAGIVTVF YLLAYAAVDL ACLALEWASA PNFRPTFQFF SWHTCLLGII SCVVMMFVIN
PVYSSASIVL LLLLLLFLHY RSPTSSWGYI SQALIFHQVR KYLLMLDSRK DHVKFWRPQV
LLMVSNPRSS CQLICFVNQL KKGGLFVLGH VQIGDLDVLP ADPVQPQYNF WLSLVDKLGV
KAFVDLTLSP SVRQGTQHLL RITGLGGMKP NTLVLGFYDN SYPEDYFLQD PVFCKGDRSE
GDNFGVDLPS LQAHFPPVRH AESPRALQPQ EYVSIIQDAI KMGKNICLAR YFFQLPPESK
GATYMWGKDS MDTIDVWPTN LLTPGSASYA DVGSLFLLQM ACVLNMASGW RRARLRIFVC
VESESEDQGW LAKEEQFREL LGKLRIRAAI KIVAWDNVAR MVRGPNTESQ PVSEDFLCAV
NGLLKEHSST AAVRFLYLPD PPSSCELSQQ YLTQLDTLTR DLGPTLLIHG VTPVTCTEL
