S12A9_XENLA
ID S12A9_XENLA Reviewed; 899 AA.
AC Q0VGW6;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Solute carrier family 12 member 9;
DE AltName: Full=Cation-chloride cotransporter-interacting protein 1;
GN Name=slc12a9; Synonyms=cip1;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=10871601; DOI=10.1074/jbc.m000108200;
RA Caron L., Rousseau F., Gagnon E., Isenring P.;
RT "Cloning and functional characterization of a cation-Cl-cotransporter-
RT interacting protein.";
RL J. Biol. Chem. 275:32027-32036(2000).
CC -!- FUNCTION: Seems to correspond to a subunit of a multimeric transport
CC system and thus, additional subunits may be required for its function.
CC {ECO:0000269|PubMed:10871601}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10871601};
CC Multi-pass membrane protein {ECO:0000269|PubMed:10871601}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family. {ECO:0000305}.
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DR EMBL; BC080420; AAH80420.1; -; mRNA.
DR RefSeq; NP_001090251.1; NM_001096782.1.
DR AlphaFoldDB; Q0VGW6; -.
DR SMR; Q0VGW6; -.
DR PRIDE; Q0VGW6; -.
DR DNASU; 779157; -.
DR GeneID; 779157; -.
DR KEGG; xla:779157; -.
DR CTD; 779157; -.
DR Xenbase; XB-GENE-5943252; slc12a9.L.
DR OMA; NAGLYVT; -.
DR OrthoDB; 515568at2759; -.
DR Proteomes; UP000186698; Chromosome 3L.
DR Bgee; 779157; Expressed in egg cell and 19 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:cation:chloride symporter activity; IEA:InterPro.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR030345; SLC12A9.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827; PTHR11827; 1.
DR PANTHER; PTHR11827:SF98; PTHR11827:SF98; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..899
FT /note="Solute carrier family 12 member 9"
FT /id="PRO_0000331419"
FT TOPO_DOM 1..44
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 66..80
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..127
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..176
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 198..202
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..266
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 288..304
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 305..325
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 326..347
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 369..393
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 394..414
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 415..419
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 420..440
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 441..469
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 470..490
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 491..739
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 740..760
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 761..899
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 235
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 246
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 899 AA; 98345 MW; 359B62D32989C0D9 CRC64;
MTSESSPLLH YRLFSVSDGG LGPPDSSPIM TDAVTVGTGP TQRKLSTFFG VVVPTVLSMF
SIVVFMRIGF VVGHAGLLQS LLMLFVAYVI IWLTVLSVCA ISTNGAVQGG GAYFMISRTL
GPEFGGSIGL MFYLANVFAC GVYVLGLVEA VLDVFGRDPS DVTDSLRSLP QGYGYSFLYA
SIILLLCMAI CLVGASIYSQ ASFFIFLLVF VVLLTILISF LAVRPLTVSI RHGGNVTMTG
VYTGINSSTL HNNLQADYSL DYTTGNLMNF ATVFAVMFNG CTGIMAGCNL SGELKQPSRS
IPMGTIIAVI ITFFVYLILF IFTAFTCDRT LLREDYGFFR SINIWPPFVL IGVYATSLSA
SMSTLIGASR ILHALAKDDL FGVLLAPAKL VSKGGNPWGA VVYTWALVQL VLLAGKLNTI
AGIVTVFYLI AYAAIDLACL ALEWASAPNF RPTFRFFSWH TCLLGILSSL VMMFLINPAY
ASGSIVLLLL LLGSIHFRSS SSSWGYISQA LIFHQVRKYL LLLDVRKDHV KFWRPQILLM
VSNPRTSSQL IRFVNDLKKG GLYILGHVET GDLDTLPSDP VQTHYSFWLS LVDKLNVKAF
VDLTLCPSVR QGTQHLLRIT GLGGMKPNTV VLGFYDDACP DDYFLQDSLF TPGLSPKDDA
FGVDATSLQA HFPPARDPET PRLLSAKDYV SMICDALKMH KNIVLARNFP LLVRPEASSS
SPATYIDVWP LDLLRPQASA YVDVCSLFLL QMACILNMAA SWRRYQLRVF LCVESRGGSD
GASGWLAAEA KFRELLSKLR IRALIRVVAW DRVAAFRVQN MGGQVLNREP ISSEYLNAAK
SAVTDEGGTE TAVRFLYLPR PPADSSLHER YLEELDTLTS GLGPTLLIHG LTPVTCTEL
