S13A1_HUMAN
ID S13A1_HUMAN Reviewed; 595 AA.
AC Q9BZW2; Q9H5Z0;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Solute carrier family 13 member 1;
DE AltName: Full=Renal sodium/sulfate cotransporter;
DE Short=Na(+)/sulfate cotransporter;
DE Short=hNaSi-1;
GN Name=SLC13A1; Synonyms=NAS1, NASI1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RC TISSUE=Kidney;
RX PubMed=11161786; DOI=10.1006/geno.2000.6404;
RA Lee A., Beck L., Markovich D.;
RT "The human renal sodium sulfate cotransporter (SLC13A1; hNaSi-1) cDNA and
RT gene: organization, chromosomal localization, and functional
RT characterization.";
RL Genomics 70:354-363(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ileal mucosa;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- FUNCTION: Sodium/sulfate cotransporter that mediates sulfate
CC reabsorption in the kidney.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Highly expressed in kidney; not detectable in the
CC other tissues tested.
CC -!- INDUCTION: Inhibited by thiosulfate, selenate, molybdate, tungstate,
CC citrate and succinate.
CC -!- SIMILARITY: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family.
CC NADC subfamily. {ECO:0000305}.
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DR EMBL; AF260824; AAG60583.1; -; mRNA.
DR EMBL; AK026413; BAB15477.1; -; mRNA.
DR CCDS; CCDS5786.1; -.
DR RefSeq; NP_001311329.1; NM_001324400.1.
DR RefSeq; NP_071889.2; NM_022444.3.
DR AlphaFoldDB; Q9BZW2; -.
DR SMR; Q9BZW2; -.
DR BioGRID; 112450; 40.
DR STRING; 9606.ENSP00000194130; -.
DR DrugBank; DB00139; Succinic acid.
DR TCDB; 2.A.47.1.16; the divalent anion:na(+) symporter (dass) family.
DR GlyGen; Q9BZW2; 3 sites.
DR PhosphoSitePlus; Q9BZW2; -.
DR BioMuta; SLC13A1; -.
DR DMDM; 23396850; -.
DR EPD; Q9BZW2; -.
DR MassIVE; Q9BZW2; -.
DR PaxDb; Q9BZW2; -.
DR PeptideAtlas; Q9BZW2; -.
DR PRIDE; Q9BZW2; -.
DR Antibodypedia; 62232; 32 antibodies from 12 providers.
DR DNASU; 6561; -.
DR Ensembl; ENST00000194130.7; ENSP00000194130.2; ENSG00000081800.9.
DR GeneID; 6561; -.
DR KEGG; hsa:6561; -.
DR MANE-Select; ENST00000194130.7; ENSP00000194130.2; NM_022444.4; NP_071889.2.
DR UCSC; uc003vkm.4; human.
DR CTD; 6561; -.
DR DisGeNET; 6561; -.
DR GeneCards; SLC13A1; -.
DR HGNC; HGNC:10916; SLC13A1.
DR HPA; ENSG00000081800; Tissue enriched (kidney).
DR MIM; 606193; gene.
DR neXtProt; NX_Q9BZW2; -.
DR OpenTargets; ENSG00000081800; -.
DR PharmGKB; PA322; -.
DR VEuPathDB; HostDB:ENSG00000081800; -.
DR eggNOG; KOG1281; Eukaryota.
DR GeneTree; ENSGT01030000234550; -.
DR HOGENOM; CLU_005170_9_1_1; -.
DR InParanoid; Q9BZW2; -.
DR OMA; YGHLTIM; -.
DR OrthoDB; 389981at2759; -.
DR PhylomeDB; Q9BZW2; -.
DR TreeFam; TF312913; -.
DR PathwayCommons; Q9BZW2; -.
DR Reactome; R-HSA-433137; Sodium-coupled sulphate, di- and tri-carboxylate transporters.
DR BioGRID-ORCS; 6561; 6 hits in 1067 CRISPR screens.
DR ChiTaRS; SLC13A1; human.
DR GenomeRNAi; 6561; -.
DR Pharos; Q9BZW2; Tbio.
DR PRO; PR:Q9BZW2; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q9BZW2; protein.
DR Bgee; ENSG00000081800; Expressed in nephron tubule and 20 other tissues.
DR ExpressionAtlas; Q9BZW2; baseline and differential.
DR Genevisible; Q9BZW2; HS.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0015382; F:sodium:sulfate symporter activity; IBA:GO_Central.
DR GO; GO:0098656; P:anion transmembrane transport; IBA:GO_Central.
DR GO; GO:0008272; P:sulfate transport; IBA:GO_Central.
DR InterPro; IPR031312; Na/sul_symport_CS.
DR InterPro; IPR001898; SLC13A/DASS.
DR Pfam; PF00939; Na_sulph_symp; 1.
DR PROSITE; PS01271; NA_SULFATE; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Ion transport; Membrane; Reference proteome; Sodium;
KW Sodium transport; Sulfate transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..595
FT /note="Solute carrier family 13 member 1"
FT /id="PRO_0000172485"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 464..484
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 491..511
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 512..532
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 554..574
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 174
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 207
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 591
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 42
FT /note="F -> L (in dbSNP:rs28364181)"
FT /id="VAR_029247"
FT VARIANT 44
FT /note="V -> I (in dbSNP:rs28364177)"
FT /id="VAR_029248"
FT VARIANT 157
FT /note="Q -> E (in dbSNP:rs28364196)"
FT /id="VAR_029249"
FT VARIANT 174
FT /note="N -> S (in dbSNP:rs2140516)"
FT /id="VAR_022018"
FT VARIANT 205
FT /note="Y -> C (in dbSNP:rs28364231)"
FT /id="VAR_029250"
FT VARIANT 240
FT /note="T -> M (in dbSNP:rs10231144)"
FT /id="VAR_059804"
FT VARIANT 277
FT /note="R -> H (in dbSNP:rs28364200)"
FT /id="VAR_029251"
FT VARIANT 332
FT /note="V -> A (in dbSNP:rs28364201)"
FT /id="VAR_029252"
FT VARIANT 392
FT /note="I -> T (in dbSNP:rs28364210)"
FT /id="VAR_029253"
FT CONFLICT 481
FT /note="V -> A (in Ref. 2; BAB15477)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 595 AA; 66134 MW; A4C48EC180F6DA14 CRC64;
MKFFSYILVY RRFLFVVFTV LVLLPLPIVL HTKEAECAYT LFVVATFWLT EALPLSVTAL
LPSLMLPMFG IMPSKKVASA YFKDFHLLLI GVICLATSIE KWNLHKRIAL KMVMMVGVNP
AWLTLGFMSS TAFLSMWLSN TSTAAMVMPI AEAVVQQIIN AEAEVEATQM TYFNGSTNHG
LEIDESVNGH EINERKEKTK PVPGYNNDTG KISSKVELEK NSGMRTKYRT KKGHVTRKLT
CLCIAYSSTI GGLTTITGTS TNLIFAEYFN TRYPDCRCLN FGSWFTFSFP AALIILLLSW
IWLQWLFLGF NFKEMFKCGK TKTVQQKACA EVIKQEYQKL GPIRYQEIVT LVLFIIMALL
WFSRDPGFVP GWSALFSEYP GFATDSTVAL LIGLLFFLIP AKTLTKTTPT GEIVAFDYSP
LITWKEFQSF MPWDIAILVG GGFALADGCE ESGLSKWIGN KLSPLGSLPA WLIILISSLM
VTSLTEVASN PATITLFLPI LSPLAEAIHV NPLYILIPST LCTSFAFLLP VANPPNAIVF
SYGHLKVIDM VKAGLGVNIV GVAVVMLGIC TWIVPMFDLY TYPSWAPAMS NETMP
