S13A1_MOUSE
ID S13A1_MOUSE Reviewed; 594 AA.
AC Q9JHI4; Q80YB5; Q8R208; Q9D2C3;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Solute carrier family 13 member 1;
DE AltName: Full=NaSi-1;
DE AltName: Full=Renal sodium/sulfate cotransporter;
DE Short=Na(+)/sulfate cotransporter;
GN Name=Slc13a1; Synonyms=Nas1, Nasi1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=129/Sv; TISSUE=Kidney;
RX PubMed=10766815; DOI=10.1074/jbc.275.16.11880;
RA Beck L., Markovich D.;
RT "The mouse Na+-sulfate cotransporter gene Nas1: cloning, tissue
RT distribution, gene structure, chromosomal assignment, and transcriptional
RT regulation by vitamin D.";
RL J. Biol. Chem. 275:11880-11890(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Ovary, and Uterus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Sodium/sulfate cotransporter that mediates sulfate
CC reabsorption in the kidney.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Comment=Experimental confirmation may be lacking for some isoforms.;
CC Name=1;
CC IsoId=Q9JHI4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9JHI4-2; Sequence=VSP_006121;
CC Name=3;
CC IsoId=Q9JHI4-3; Sequence=VSP_006122;
CC -!- TISSUE SPECIFICITY: Highly expressed in kidney and ileum, detected at
CC lower levels in duodenum/jejunum and colon, and at very low levels in
CC cecum, testis, adrenal and adipose tissues. Expression of isoform 2 is
CC very low.
CC -!- MISCELLANEOUS: [Isoform 2]: Inactive. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 3]: Inactive. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family.
CC NADC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AK019876; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF199365; AAF64648.1; -; mRNA.
DR EMBL; AF199366; AAF64649.1; -; mRNA.
DR EMBL; AF200319; AAF65231.1; -; Genomic_DNA.
DR EMBL; AF200305; AAF65231.1; JOINED; Genomic_DNA.
DR EMBL; AF200306; AAF65231.1; JOINED; Genomic_DNA.
DR EMBL; AF200307; AAF65231.1; JOINED; Genomic_DNA.
DR EMBL; AF200308; AAF65231.1; JOINED; Genomic_DNA.
DR EMBL; AF200309; AAF65231.1; JOINED; Genomic_DNA.
DR EMBL; AF200310; AAF65231.1; JOINED; Genomic_DNA.
DR EMBL; AF200311; AAF65231.1; JOINED; Genomic_DNA.
DR EMBL; AF200312; AAF65231.1; JOINED; Genomic_DNA.
DR EMBL; AF200313; AAF65231.1; JOINED; Genomic_DNA.
DR EMBL; AF200314; AAF65231.1; JOINED; Genomic_DNA.
DR EMBL; AF200315; AAF65231.1; JOINED; Genomic_DNA.
DR EMBL; AF200316; AAF65231.1; JOINED; Genomic_DNA.
DR EMBL; AF200317; AAF65231.1; JOINED; Genomic_DNA.
DR EMBL; AF200318; AAF65231.1; JOINED; Genomic_DNA.
DR EMBL; AK019876; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; CH466533; EDL13827.1; -; Genomic_DNA.
DR EMBL; BC049981; AAH49981.1; -; mRNA.
DR EMBL; BC022672; AAH22672.1; -; mRNA.
DR CCDS; CCDS19940.1; -. [Q9JHI4-1]
DR RefSeq; NP_062354.2; NM_019481.2. [Q9JHI4-1]
DR AlphaFoldDB; Q9JHI4; -.
DR SMR; Q9JHI4; -.
DR STRING; 10090.ENSMUSP00000031713; -.
DR GlyGen; Q9JHI4; 2 sites.
DR iPTMnet; Q9JHI4; -.
DR PhosphoSitePlus; Q9JHI4; -.
DR PaxDb; Q9JHI4; -.
DR PRIDE; Q9JHI4; -.
DR ProteomicsDB; 253346; -. [Q9JHI4-1]
DR ProteomicsDB; 253347; -. [Q9JHI4-2]
DR ProteomicsDB; 253348; -. [Q9JHI4-3]
DR Antibodypedia; 62232; 32 antibodies from 12 providers.
DR DNASU; 55961; -.
DR Ensembl; ENSMUST00000031713; ENSMUSP00000031713; ENSMUSG00000029700. [Q9JHI4-1]
DR GeneID; 55961; -.
DR KEGG; mmu:55961; -.
DR UCSC; uc009bbo.2; mouse. [Q9JHI4-1]
DR UCSC; uc009bbq.1; mouse. [Q9JHI4-3]
DR CTD; 6561; -.
DR MGI; MGI:1859937; Slc13a1.
DR VEuPathDB; HostDB:ENSMUSG00000029700; -.
DR eggNOG; KOG1281; Eukaryota.
DR GeneTree; ENSGT01030000234550; -.
DR HOGENOM; CLU_005170_9_1_1; -.
DR InParanoid; Q9JHI4; -.
DR OMA; YGHLTIM; -.
DR OrthoDB; 389981at2759; -.
DR PhylomeDB; Q9JHI4; -.
DR TreeFam; TF312913; -.
DR Reactome; R-MMU-433137; Sodium-coupled sulphate, di- and tri-carboxylate transporters.
DR BioGRID-ORCS; 55961; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Slc13a1; mouse.
DR PRO; PR:Q9JHI4; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9JHI4; protein.
DR Bgee; ENSMUSG00000029700; Expressed in right kidney and 79 other tissues.
DR Genevisible; Q9JHI4; MM.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:MGI.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IDA:MGI.
DR GO; GO:0015382; F:sodium:sulfate symporter activity; ISO:MGI.
DR GO; GO:0098656; P:anion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006814; P:sodium ion transport; ISO:MGI.
DR GO; GO:0008272; P:sulfate transport; IDA:MGI.
DR InterPro; IPR031312; Na/sul_symport_CS.
DR InterPro; IPR001898; SLC13A/DASS.
DR Pfam; PF00939; Na_sulph_symp; 1.
DR PROSITE; PS01271; NA_SULFATE; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Ion transport; Membrane;
KW Reference proteome; Sodium; Sodium transport; Sulfate transport; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..594
FT /note="Solute carrier family 13 member 1"
FT /id="PRO_0000172486"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 461..481
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 487..507
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 511..531
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 552..572
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 192..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 174
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 590
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 34..76
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10766815"
FT /id="VSP_006121"
FT VAR_SEQ 123..594
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_006122"
FT CONFLICT 470
FT /note="W -> R (in Ref. 1; AAF64648/AAF64649/AAF65231)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 594 AA; 66084 MW; 7B8C347B9DA8F3C6 CRC64;
MKLLNYALVY RRFLLVVFTI LVFLPLPLII RTKEAQCAYI LFVIAIFWIT EALPLSITAL
LPGLMFPMFG IMRSSQVASA YFKDFHLLLI GVICLATSIE KWNLHKRIAL RMVMMVGVNP
AWLTLGFMSS TAFLSMWLSN TSTAAMVMPI VEAVAQQIIS AEAEAEATQM TYFNESAAHG
LDIDETVIGQ ETNEKKEKTK PAPGSSHDKG KVSRKMETEK NAVTGAKYRS RKDHMMCKLM
CLSVAYSSTI GGLTTITGTS TNLIFSEHFN TRYPDCRCLN FGSWFLFSFP VALILLLLSW
IWLQWLYLGF DFKMFKCGKT KTLKEKACAK VIKQEYEKLG PMRYQEIVTL VIFIVMALLW
FSRDPGFVTG WSVLFSEYPG YVTDSTVALV AGILFFLIPA KKVTKMTSAG EIIAFDYTPL
ITWKEFQSFM PWDIAILVGG GFALADGCQV SGLSNWIGSK LSPLGSLPVW LIILISSLIV
TSLTEVASNP ATITILFPIL SPLAEAIQVN PLQILLPSTL CTSFAFLLPV ANPPNAIVFS
YGHLKVIDMV KAGLGVNILG VAVVMLGMFT WIEPMFNLHE YPSWASNFVN QTMP
