S13A1_RAT
ID S13A1_RAT Reviewed; 595 AA.
AC Q07782;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Solute carrier family 13 member 1;
DE AltName: Full=NaSi-1;
DE AltName: Full=Renal sodium/sulfate cotransporter;
DE Short=Na(+)/sulfate cotransporter;
GN Name=Slc13a1; Synonyms=Nas1, Nasi1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Kidney cortex;
RX PubMed=7690140; DOI=10.1073/pnas.90.17.8073;
RA Markovich D., Forgo J., Stange G., Biber J., Murer H.;
RT "Expression cloning of rat renal Na+/SO4(2-) cotransport.";
RL Proc. Natl. Acad. Sci. U.S.A. 90:8073-8077(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Small intestine;
RX PubMed=7816544; DOI=10.1007/bf00724500;
RA Norbis F., Perego C., Markovich D., Stange G., Verri T., Murer H.;
RT "cDNA cloning of a rat small-intestinal Na+/SO4(2-) cotransporter.";
RL Pflugers Arch. 428:217-223(1994).
CC -!- FUNCTION: Sodium/sulfate cotransporter that mediates sulfate
CC reabsorption in the kidney.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Kidney and intestine.
CC -!- SIMILARITY: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family.
CC NADC subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L19102; AAA41677.1; -; mRNA.
DR EMBL; U08031; AAB48989.1; -; mRNA.
DR PIR; A47714; A47714.
DR RefSeq; NP_113839.1; NM_031651.1.
DR AlphaFoldDB; Q07782; -.
DR SMR; Q07782; -.
DR STRING; 10116.ENSRNOP00000010788; -.
DR TCDB; 2.A.47.1.2; the divalent anion:na(+) symporter (dass) family.
DR GlyGen; Q07782; 2 sites.
DR PaxDb; Q07782; -.
DR Ensembl; ENSRNOT00000010788; ENSRNOP00000010788; ENSRNOG00000008121.
DR GeneID; 58980; -.
DR KEGG; rno:58980; -.
DR UCSC; RGD:61919; rat.
DR CTD; 6561; -.
DR RGD; 61919; Slc13a1.
DR eggNOG; KOG1281; Eukaryota.
DR GeneTree; ENSGT01030000234550; -.
DR HOGENOM; CLU_005170_9_1_1; -.
DR InParanoid; Q07782; -.
DR OMA; YGHLTIM; -.
DR OrthoDB; 389981at2759; -.
DR PhylomeDB; Q07782; -.
DR TreeFam; TF312913; -.
DR Reactome; R-RNO-433137; Sodium-coupled sulphate, di- and tri-carboxylate transporters.
DR PRO; PR:Q07782; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000008121; Expressed in duodenum and 9 other tissues.
DR Genevisible; Q07782; RN.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; ISO:RGD.
DR GO; GO:0015382; F:sodium:sulfate symporter activity; IDA:RGD.
DR GO; GO:0098656; P:anion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006814; P:sodium ion transport; IDA:RGD.
DR GO; GO:0008272; P:sulfate transport; IDA:RGD.
DR InterPro; IPR031312; Na/sul_symport_CS.
DR InterPro; IPR001898; SLC13A/DASS.
DR Pfam; PF00939; Na_sulph_symp; 1.
DR PROSITE; PS01271; NA_SULFATE; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Ion transport; Membrane; Reference proteome; Sodium;
KW Sodium transport; Sulfate transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..595
FT /note="Solute carrier family 13 member 1"
FT /id="PRO_0000172487"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 464..484
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 491..511
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 512..532
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 553..573
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 190..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..204
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 174
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 591
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 595 AA; 66059 MW; C905A5898622E317 CRC64;
MKLLNYAFVY RRFLLVVFTV LVLLPLPLII RSKEAECAYI LFVIATFWIT EALPLSITAL
LPGLMFPMFG IMSSTHVASA YFKDFHLLLI GVICLATSIE KWNLHKRIAL RMVMMVGVNP
AWLTLGFMSS TAFLSMWLSN TSTAAMVMPI VEAVAQQITS AEAEAEATQM TYFNESAAQG
LEVDETIIGQ ETNERKEKTK PALGSSNDKG KVSSKMETEK NTVTGAKYRS KKDHMMCKLM
CLCIAYSSTI GGLTTITGTS TNLIFSEHFN TRYPDCRCLN FGSWFLFSFP VAVILLLLSW
IWLQWLFLGF NFKEMFKCGK TKTLKEKACA EVIKQEYEKL GPMRYQEIVT LVIFIVMALL
WFSRDPGFVT GWSVLFSEYP GYVTDSTVAL VAGILFFLIP AKKLTKMTST GDIIAFDYSP
LITWKEFQSF MPWDIAILVG GGFALADGCQ VSGLSSWIGS KLSPLGSLPV WLIILISSLI
VTSLTEVASN PATITILFPI LSPLAEAIHV NPLHILLPST LCTSFAFLLP VANPPNAIVF
SYGHLKVIDM VKAGLGVNIL GVAVVMLGMF TWIEPMFNLH EYPSWAPDIV NQTMP
