S13A2_HUMAN
ID S13A2_HUMAN Reviewed; 592 AA.
AC Q13183; B2RBI9; B4DPL1; E7ETH5; Q4VAR7;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=Solute carrier family 13 member 2;
DE AltName: Full=Na(+)/dicarboxylate cotransporter 1;
DE Short=NaDC-1;
DE AltName: Full=Renal sodium/dicarboxylate cotransporter;
GN Name=SLC13A2; Synonyms=NADC1, SDCT1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Kidney;
RX PubMed=8967342; DOI=10.1152/ajprenal.1996.270.4.f642;
RA Pajor A.M.;
RT "Molecular cloning and functional expression of a sodium-dicarboxylate
RT cotransporter from human kidney.";
RL Am. J. Physiol. 270:F642-F648(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP VAL-550.
RC TISSUE=Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP VARIANT VAL-550.
RX PubMed=17470169; DOI=10.1111/j.1442-2042.2007.01554.x;
RA Okamoto N., Aruga S., Matsuzaki S., Takahashi S., Matsushita K.,
RA Kitamura T.;
RT "Associations between renal sodium-citrate cotransporter (hNaDC-1) gene
RT polymorphism and urinary citrate excretion in recurrent renal calcium stone
RT formers and normal controls.";
RL Int. J. Urol. 14:344-349(2007).
CC -!- FUNCTION: Cotransport of sodium ions and dicarboxylates such as
CC succinate and citrate.
CC -!- INTERACTION:
CC Q13183; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-17460043, EBI-6942903;
CC Q13183; P48165: GJA8; NbExp=3; IntAct=EBI-17460043, EBI-17458373;
CC Q13183; O76024: WFS1; NbExp=3; IntAct=EBI-17460043, EBI-720609;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q13183-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q13183-2; Sequence=VSP_046426, VSP_046427;
CC Name=3;
CC IsoId=Q13183-3; Sequence=VSP_046427;
CC -!- SIMILARITY: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family.
CC NADC subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U26209; AAA98504.1; -; mRNA.
DR EMBL; AK298388; BAG60623.1; -; mRNA.
DR EMBL; AK314684; BAG37236.1; -; mRNA.
DR EMBL; AC015917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC096277; AAH96277.1; -; mRNA.
DR EMBL; BC096278; AAH96278.1; -; mRNA.
DR EMBL; BC096279; AAH96279.1; -; mRNA.
DR CCDS; CCDS11231.1; -. [Q13183-1]
DR CCDS; CCDS54098.1; -. [Q13183-3]
DR RefSeq; NP_001139447.1; NM_001145975.1. [Q13183-3]
DR RefSeq; NP_003975.1; NM_003984.3. [Q13183-1]
DR AlphaFoldDB; Q13183; -.
DR SMR; Q13183; -.
DR BioGRID; 114520; 18.
DR IntAct; Q13183; 14.
DR STRING; 9606.ENSP00000392411; -.
DR BindingDB; Q13183; -.
DR ChEMBL; CHEMBL3712851; -.
DR DrugBank; DB09154; Sodium citrate.
DR DrugBank; DB00139; Succinic acid.
DR TCDB; 2.A.47.1.17; the divalent anion:na(+) symporter (dass) family.
DR iPTMnet; Q13183; -.
DR PhosphoSitePlus; Q13183; -.
DR BioMuta; SLC13A2; -.
DR DMDM; 2499523; -.
DR MassIVE; Q13183; -.
DR PeptideAtlas; Q13183; -.
DR PRIDE; Q13183; -.
DR ProteomicsDB; 18206; -.
DR ProteomicsDB; 59209; -. [Q13183-1]
DR Antibodypedia; 14078; 79 antibodies from 21 providers.
DR DNASU; 9058; -.
DR Ensembl; ENST00000314669.10; ENSP00000316202.6; ENSG00000007216.16. [Q13183-1]
DR Ensembl; ENST00000444914.7; ENSP00000392411.3; ENSG00000007216.16. [Q13183-3]
DR GeneID; 9058; -.
DR KEGG; hsa:9058; -.
DR MANE-Select; ENST00000314669.10; ENSP00000316202.6; NM_003984.4; NP_003975.1.
DR UCSC; uc002hbh.4; human. [Q13183-1]
DR CTD; 9058; -.
DR DisGeNET; 9058; -.
DR GeneCards; SLC13A2; -.
DR HGNC; HGNC:10917; SLC13A2.
DR HPA; ENSG00000007216; Group enriched (intestine, kidney, salivary gland).
DR MIM; 604148; gene.
DR neXtProt; NX_Q13183; -.
DR OpenTargets; ENSG00000007216; -.
DR PharmGKB; PA382; -.
DR VEuPathDB; HostDB:ENSG00000007216; -.
DR eggNOG; KOG1281; Eukaryota.
DR GeneTree; ENSGT01030000234550; -.
DR HOGENOM; CLU_005170_9_1_1; -.
DR InParanoid; Q13183; -.
DR OMA; EAYCAYT; -.
DR OrthoDB; 389981at2759; -.
DR PhylomeDB; Q13183; -.
DR TreeFam; TF312913; -.
DR PathwayCommons; Q13183; -.
DR Reactome; R-HSA-433137; Sodium-coupled sulphate, di- and tri-carboxylate transporters.
DR SABIO-RK; Q13183; -.
DR SignaLink; Q13183; -.
DR BioGRID-ORCS; 9058; 29 hits in 1075 CRISPR screens.
DR ChiTaRS; SLC13A2; human.
DR GeneWiki; SLC13A2; -.
DR GenomeRNAi; 9058; -.
DR Pharos; Q13183; Tbio.
DR PRO; PR:Q13183; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q13183; protein.
DR Bgee; ENSG00000007216; Expressed in jejunal mucosa and 72 other tissues.
DR ExpressionAtlas; Q13183; baseline and differential.
DR Genevisible; Q13183; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0016020; C:membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0015361; F:low-affinity sodium:dicarboxylate symporter activity; TAS:Reactome.
DR GO; GO:0015141; F:succinate transmembrane transporter activity; IDA:ARUK-UCL.
DR GO; GO:0098656; P:anion transmembrane transport; IBA:GO_Central.
DR GO; GO:0071422; P:succinate transmembrane transport; IDA:ARUK-UCL.
DR InterPro; IPR031312; Na/sul_symport_CS.
DR InterPro; IPR001898; SLC13A/DASS.
DR Pfam; PF00939; Na_sulph_symp; 1.
DR PROSITE; PS01271; NA_SULFATE; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Ion transport; Membrane; Reference proteome; Sodium;
KW Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..592
FT /note="Solute carrier family 13 member 2"
FT /id="PRO_0000172488"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 371..391
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 450..470
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 482..502
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 511..531
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 545..565
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 165..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..44
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_046426"
FT VAR_SEQ 77
FT /note="E -> EIIQRPFPSSFESPGECQSVGMSVTASHNLGGTVGDSRVFPPLSHVS
FT TCQ (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_046427"
FT VARIANT 44
FT /note="L -> F (in dbSNP:rs45443898)"
FT /id="VAR_029254"
FT VARIANT 45
FT /note="M -> L (in dbSNP:rs16964363)"
FT /id="VAR_052000"
FT VARIANT 254
FT /note="F -> L (in dbSNP:rs11568461)"
FT /id="VAR_029255"
FT VARIANT 310
FT /note="A -> P (in dbSNP:rs11568441)"
FT /id="VAR_029256"
FT VARIANT 385
FT /note="P -> S (in dbSNP:rs45546232)"
FT /id="VAR_020399"
FT VARIANT 477
FT /note="V -> M (in dbSNP:rs11568476)"
FT /id="VAR_029257"
FT VARIANT 550
FT /note="I -> V (in dbSNP:rs11567842)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:17470169"
FT /id="VAR_020400"
FT CONFLICT 307
FT /note="Q -> R (in Ref. 2; BAG60623)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 592 AA; 64410 MW; 41137D6621A0872A CRC64;
MATCWQALWA YRSYLIVFFV PILLLPLPIL VPSKEAYCAY AIILMALFWC TEALPLAVTA
LFPLILFPMM GIVDASEVAV EYLKDSNLLF FGGLLVAIAV EHWNLHKRIA LRVLLIVGVR
PAPLILGFML VTAFLSMWIS NTATSAMMVP IAHAVLDQLH SSQASSNVEE GSNNPTFELQ
EPSPQKEVTK LDNGQALPVT SASSEGRAHL SQKHLHLTQC MSLCVCYSAS IGGIATLTGT
APNLVLQGQI NSLFPQNGNV VNFASWFSFA FPTMVILLLL AWLWLQILFL GFNFRKNFGI
GEKMQEQQQA AYCVIQTEHR LLGPMTFAEK AISILFVILV LLWFTREPGF FLGWGNLAFP
NAKGESMVSD GTVAIFIGII MFIIPSKFPG LTQDPENPGK LKAPLGLLDW KTVNQKMPWN
IVLLLGGGYA LAKGSERSGL SEWLGNKLTP LQSVPAPAIA IILSLLVATF TECTSNVATT
TIFLPILASM AQAICLHPLY VMLPCTLATS LAFMLPVATP PNAIVFSFGD LKVLDMARAG
FLLNIIGVLI IALAINSWGI PLFSLHSFPS WAQSNTTAQC LPSLANTTTP SP
