S13A2_MOUSE
ID S13A2_MOUSE Reviewed; 586 AA.
AC Q9ES88;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Solute carrier family 13 member 2;
DE AltName: Full=Na(+)/dicarboxylate cotransporter 1;
DE Short=NaDC-1;
DE AltName: Full=Renal sodium/dicarboxylate cotransporter;
GN Name=Slc13a2; Synonyms=Nadc1, Sdct1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Kidney;
RX PubMed=10966927; DOI=10.1152/ajprenal.2000.279.3.f482;
RA Pajor A.M., Sun N.N.;
RT "Molecular cloning, chromosomal organization and functional
RT characterization of a sodium/dicarboxylate cotransporter from mouse
RT kidney.";
RL Am. J. Physiol. 279:F482-F490(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Cotransport of sodium ions and dicarboxylates such as
CC succinate and citrate.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Highly expressed in kidney and small intestine. Not
CC detectable in brain, heart, stomach and skeletal muscle.
CC -!- SIMILARITY: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family.
CC NADC subfamily. {ECO:0000305}.
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DR EMBL; AF201903; AAG15426.1; -; mRNA.
DR EMBL; BC013493; AAH13493.1; -; mRNA.
DR CCDS; CCDS25103.1; -.
DR RefSeq; NP_071856.1; NM_022411.3.
DR AlphaFoldDB; Q9ES88; -.
DR SMR; Q9ES88; -.
DR STRING; 10090.ENSMUSP00000001122; -.
DR iPTMnet; Q9ES88; -.
DR PhosphoSitePlus; Q9ES88; -.
DR PaxDb; Q9ES88; -.
DR PRIDE; Q9ES88; -.
DR ProteomicsDB; 255441; -.
DR Antibodypedia; 14078; 79 antibodies from 21 providers.
DR DNASU; 20500; -.
DR Ensembl; ENSMUST00000001122; ENSMUSP00000001122; ENSMUSG00000001095.
DR GeneID; 20500; -.
DR KEGG; mmu:20500; -.
DR UCSC; uc007kjf.1; mouse.
DR CTD; 9058; -.
DR MGI; MGI:1276558; Slc13a2.
DR VEuPathDB; HostDB:ENSMUSG00000001095; -.
DR eggNOG; KOG1281; Eukaryota.
DR GeneTree; ENSGT01030000234550; -.
DR HOGENOM; CLU_005170_9_1_1; -.
DR InParanoid; Q9ES88; -.
DR OMA; EAYCAYT; -.
DR OrthoDB; 389981at2759; -.
DR PhylomeDB; Q9ES88; -.
DR TreeFam; TF312913; -.
DR Reactome; R-MMU-433137; Sodium-coupled sulphate, di- and tri-carboxylate transporters.
DR BioGRID-ORCS; 20500; 4 hits in 72 CRISPR screens.
DR PRO; PR:Q9ES88; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9ES88; protein.
DR Bgee; ENSMUSG00000001095; Expressed in small intestine Peyer's patch and 59 other tissues.
DR Genevisible; Q9ES88; MM.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0015141; F:succinate transmembrane transporter activity; IDA:ARUK-UCL.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0098656; P:anion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0071422; P:succinate transmembrane transport; IDA:ARUK-UCL.
DR InterPro; IPR031312; Na/sul_symport_CS.
DR InterPro; IPR001898; SLC13A/DASS.
DR Pfam; PF00939; Na_sulph_symp; 1.
DR PROSITE; PS01271; NA_SULFATE; 1.
PE 2: Evidence at transcript level;
KW Ion transport; Membrane; Reference proteome; Sodium; Sodium transport;
KW Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..586
FT /note="Solute carrier family 13 member 2"
FT /id="PRO_0000172489"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 319..339
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 407..427
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 445..465
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 478..498
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 506..526
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 535..555
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 165..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 586 AA; 64111 MW; 56EEAE21532833EE CRC64;
MATCWQALWA YRSYLIVLCL PIFLLPLPLI VQTKEAYCAY SIILMALLWC TEALPLAVTA
LFPIILFPLM GIMEASKVCL EYFKDTNILF VGGLMVAIAV EHWNLHKRIA LGVLLIIGVR
PALLLLGFML VTAFLSMWIS NTATTAMMLP IGYAVLEQLQ GSQKDVEEGN SNPSFELQEA
SPQKEETKLD NGQAVSVSSE PRAQKTKEHH RFSQGLSLCI CYSASIGGIA TLTGTTPNLV
LQGQVNSIFP ENSNVVNFAS WFGFAFPTMV ILLLLAWLWL QVLFLGVNFR KNFGFGEGEE
ERKQAAFQVI KTQHRLLGPM SFAEKAVTFL FVLLVVLWFT REPGFFPGWG DTAFANKKGQ
SMVSDGTVAI FISLIMFIIP SKIPGLTEDP KKPGKLKAPP AILTWKTVND KMPWNILILL
GGGFALAKGS EESGLSKWLG DKLTPLQHVP PSATVLILSL LVAIFTECTS NVATTTLFLP
ILASMAQAIC LHPLYVMLPC TLAASLAFML PVATPPNAIV FSFGGLKVSD MARAGFLLNI
IGVLTITLSI NSWSIPIFKL DTFPTWAYSN TSQCLLNPPN STVPGH
