ID   S13A2_RABIT             Reviewed;         593 AA.
AC   Q28615;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Solute carrier family 13 member 2;
DE   AltName: Full=Na(+)/dicarboxylate cotransporter 1;
DE            Short=NaDC-1;
DE   AltName: Full=Renal sodium/dicarboxylate cotransporter;
GN   Name=SLC13A2; Synonyms=NADC1, SDCT1;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=New Zealand white; TISSUE=Kidney cortex;
RX   PubMed=7890707; DOI=10.1074/jbc.270.11.5779;
RA   Pajor A.M.;
RT   "Sequence and functional characterization of a renal sodium/dicarboxylate
RT   cotransporter.";
RL   J. Biol. Chem. 270:5779-5785(1995).
CC   -!- FUNCTION: Cotransport of sodium ions and dicarboxylates such as
CC       succinate and citrate.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Abundant in kidney and small intestine.
CC   -!- SIMILARITY: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family.
CC       NADC subfamily. {ECO:0000305}.
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DR   EMBL; U12186; AAA99666.1; -; mRNA.
DR   PIR; I46528; I46528.
DR   RefSeq; NP_001171063.1; NM_001177592.1.
DR   AlphaFoldDB; Q28615; -.
DR   SMR; Q28615; -.
DR   STRING; 9986.ENSOCUP00000011839; -.
DR   PRIDE; Q28615; -.
DR   GeneID; 100009593; -.
DR   KEGG; ocu:100009593; -.
DR   CTD; 9058; -.
DR   eggNOG; KOG1281; Eukaryota.
DR   InParanoid; Q28615; -.
DR   OrthoDB; 389981at2759; -.
DR   TreeFam; TF312913; -.
DR   SABIO-RK; Q28615; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0098656; P:anion transmembrane transport; IEA:UniProt.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR031312; Na/sul_symport_CS.
DR   InterPro; IPR001898; SLC13A/DASS.
DR   Pfam; PF00939; Na_sulph_symp; 1.
DR   PROSITE; PS01271; NA_SULFATE; 1.
PE   2: Evidence at transcript level;
KW   Ion transport; Membrane; Reference proteome; Sodium; Sodium transport;
KW   Symport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..593
FT                   /note="Solute carrier family 13 member 2"
FT                   /id="PRO_0000172490"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        327..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        369..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        451..471
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        485..505
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        514..534
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        543..563
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          164..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        164..182
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   593 AA;  65125 MW;  293B6DB915D9E2BC CRC64;
     MATCWQGLWA YRMYLLVFLL PISLLPLPIL VPRKEAYCAY AIILMALFWC TDALPLAVTA
     LLPLCLFPMM GIMEASEVGL EYLKDTNVLF IGGLLLAIAV EHWNLHKRIA LRVLLLTGVR
     PALLILGFMV VTAFLSMWIS NTASTAMMVP IAHAVLQELN NTQSNVEEGS DNPTFELQEP
     SPQKETSKVD EKDNGQAQPL PAVPLESGEH MTQEQLRFSQ GMSLCVCYSA SIGGIATLTG
     TTPNLVLQGQ MTSLFPQNPN VVNFASWFGF AFPIMVILLL LSWLWLQILF LGINFRKNFG
     IREQEHEQQR KQAAYRVIQT QYRLLGPMSF AEKAVFILFV ILVLLWFTRE PGFFHGWGNL
     VFSDASGRVM VSDGSASILI GVFLFMVPSK IPGLTQDPDN PGRLKAPPAL LNWKLVNKKM
     PWNIVLLLGG GYALAKGSEE SGLSQWLGNK LMPLQHVPPP ATVFIICLLV ATFTECTSNA
     ATTTLLLPIL ASMAQAICLH PLYVMLPCTL ASSLAFMLPV ATPPNAIVFS FGGLRVSDMA
     RAGIMLNIIG VLVIMLAINS WGVPMFQLHT FPSWAHSNST THCLASPPTA PSP