ID   S13A2_RAT               Reviewed;         587 AA.
AC   P70545;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2002, sequence version 2.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Solute carrier family 13 member 2;
DE   AltName: Full=Intestinal sodium/dicarboxylate cotransporter;
DE   AltName: Full=Na(+)/dicarboxylate cotransporter 1;
DE            Short=NaDC-1;
GN   Name=Slc13a2; Synonyms=Nadc1, Sdct1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar;
RX   PubMed=8950177; DOI=10.1016/s0167-4781(96)00138-8;
RA   Khatri I.A., Kovacs S.V.B., Forstner J.F.;
RT   "Cloning of the cDNA for a rat intestinal Na+/dicarboxylate cotransporter
RT   reveals partial sequence homology with a rat intestinal mucin.";
RL   Biochim. Biophys. Acta 1309:58-62(1996).
CC   -!- FUNCTION: Cotransport of sodium ions and dicarboxylates such as
CC       succinate and citrate.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family.
CC       NADC subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB97095.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; U51153; AAB97095.1; ALT_FRAME; mRNA.
DR   AlphaFoldDB; P70545; -.
DR   SMR; P70545; -.
DR   STRING; 10116.ENSRNOP00000038185; -.
DR   PaxDb; P70545; -.
DR   RGD; 61920; Slc13a2.
DR   eggNOG; KOG1281; Eukaryota.
DR   InParanoid; P70545; -.
DR   PhylomeDB; P70545; -.
DR   Reactome; R-RNO-433137; Sodium-coupled sulphate, di- and tri-carboxylate transporters.
DR   PRO; PR:P70545; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0015141; F:succinate transmembrane transporter activity; ISO:RGD.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0098656; P:anion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0071422; P:succinate transmembrane transport; ISO:RGD.
DR   InterPro; IPR031312; Na/sul_symport_CS.
DR   InterPro; IPR001898; SLC13A/DASS.
DR   Pfam; PF00939; Na_sulph_symp; 1.
DR   PROSITE; PS01271; NA_SULFATE; 1.
PE   2: Evidence at transcript level;
KW   Ion transport; Membrane; Reference proteome; Sodium; Sodium transport;
KW   Symport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..587
FT                   /note="Solute carrier family 13 member 2"
FT                   /id="PRO_0000172491"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        329..349
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        367..387
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        407..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        445..465
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        477..497
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        506..526
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        535..555
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          187..207
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   587 AA;  64207 MW;  964D80661F1EBE0A CRC64;
     MATCWPALWA YRFYLIVLCL PIFLLPLPLI VQTKEAYCAY SIILMALLWC TEALPLAVTV
     LFPIVLFLLM GIMDASEGLE YFKDTNILFV GGLMVAIAVE HWNLHKRIAL QVLLIIGVRA
     ALLLLGFMLV TAFLSMWISN TATTAMMVPI GHAVLEQLQA SKKDVEGGNN NPTFELQEEC
     PQKEVTKLDN GQPVSAPSEP RTQKTQEHHR FSQGLSLCIC YSASIGGIDN LTGTTPNLVL
     QGQVNSLFPQ NANVVNFASW FGFAFPTMII LLLLAWLWLQ VLFLGVNFRK NFGFGEGEEE
     RKQAAFQVIK TQYRLLGPMS FAEKTCSTVL FVLLVVLWFT REPGFFPGWG DTVFANEKGQ
     SMPSDGTVAI FISLVMFIIP SKIPGLMEDP KKPGKLKAPP AILTWKTVND KMPWNIVILL
     GGGFALAKGS EQSGLSEWLG DKLTPLQHIP PSATAVILCL LIAIFTECTS NVATTTLFLP
     ILASMAQAIC LHPLYVMLPC TLAASLAFML PVATPPNAIV FSFGGLKVSD MARAGFLLNI
     IGVLATTLSI NSWSIPIFKL DTFPSWAHSN TSQCLLNPSN STVPGGL