S13A4_HUMAN
ID S13A4_HUMAN Reviewed; 626 AA.
AC Q9UKG4; A4D1Q4; Q8N631;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2009, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Solute carrier family 13 member 4;
DE AltName: Full=Na(+)/sulfate cotransporter SUT-1;
DE AltName: Full=NaS2;
GN Name=SLC13A4; Synonyms=SUT1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Endothelial cell;
RX PubMed=10535998; DOI=10.1073/pnas.96.22.12772;
RA Girard J.-P., Baekkevold E.S., Feliu J., Brandtzaeg P., Amalric F.;
RT "Molecular cloning and functional analysis of SUT-1, a sulfate transporter
RT from human high endothelial venules.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:12772-12777(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=15607730; DOI=10.1016/j.bbrc.2004.11.102;
RA Markovich D., Regeer R.R., Kunzelmann K., Dawson P.A.;
RT "Functional characterization and genomic organization of the human Na(+)-
RT sulfate cotransporter hNaS2 gene (SLC13A4).";
RL Biochem. Biophys. Res. Commun. 326:729-734(2005).
CC -!- FUNCTION: Sodium/sulfate cotransporter that mediates sulfate
CC reabsorption in the high endothelial venules (HEV).
CC {ECO:0000269|PubMed:10535998, ECO:0000269|PubMed:15607730}.
CC -!- INTERACTION:
CC Q9UKG4; O00590: ACKR2; NbExp=3; IntAct=EBI-12808018, EBI-13379418;
CC Q9UKG4; P27352: CBLIF; NbExp=3; IntAct=EBI-12808018, EBI-3953638;
CC Q9UKG4; P11912: CD79A; NbExp=6; IntAct=EBI-12808018, EBI-7797864;
CC Q9UKG4; Q92903: CDS1; NbExp=3; IntAct=EBI-12808018, EBI-13295305;
CC Q9UKG4; Q9HA82: CERS4; NbExp=3; IntAct=EBI-12808018, EBI-2622997;
CC Q9UKG4; Q8NET1: DEFB108B; NbExp=3; IntAct=EBI-12808018, EBI-13346443;
CC Q9UKG4; Q96Q80: DERL3; NbExp=3; IntAct=EBI-12808018, EBI-12831318;
CC Q9UKG4; P52803: EFNA5; NbExp=3; IntAct=EBI-12808018, EBI-1753674;
CC Q9UKG4; Q5NDL2-3: EOGT; NbExp=3; IntAct=EBI-12808018, EBI-13052900;
CC Q9UKG4; Q7Z2K6: ERMP1; NbExp=3; IntAct=EBI-12808018, EBI-10976398;
CC Q9UKG4; P36382: GJA5; NbExp=3; IntAct=EBI-12808018, EBI-750433;
CC Q9UKG4; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-12808018, EBI-13345167;
CC Q9UKG4; Q9BZJ8: GPR61; NbExp=3; IntAct=EBI-12808018, EBI-12808020;
CC Q9UKG4; P46695: IER3; NbExp=3; IntAct=EBI-12808018, EBI-1748945;
CC Q9UKG4; P24593: IGFBP5; NbExp=3; IntAct=EBI-12808018, EBI-720480;
CC Q9UKG4; Q5J8X5: MS4A13; NbExp=3; IntAct=EBI-12808018, EBI-12070086;
CC Q9UKG4; P41143: OPRD1; NbExp=3; IntAct=EBI-12808018, EBI-2624456;
CC Q9UKG4; Q7RTS5: OTOP3; NbExp=3; IntAct=EBI-12808018, EBI-12853910;
CC Q9UKG4; Q96G79: SLC35A4; NbExp=3; IntAct=EBI-12808018, EBI-12363689;
CC Q9UKG4; Q6ICL7: SLC35E4; NbExp=3; IntAct=EBI-12808018, EBI-12867720;
CC Q9UKG4; Q9H2H9: SLC38A1; NbExp=3; IntAct=EBI-12808018, EBI-9978441;
CC Q9UKG4; Q8IVJ1: SLC41A1; NbExp=3; IntAct=EBI-12808018, EBI-12266234;
CC Q9UKG4; Q9BVK8: TMEM147; NbExp=3; IntAct=EBI-12808018, EBI-348587;
CC Q9UKG4; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-12808018, EBI-2852148;
CC Q9UKG4; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-12808018, EBI-11988865;
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Highly expressed in placenta and testis with
CC intermediate levels in brain and lower levels in heart, thymus and
CC liver. {ECO:0000269|PubMed:10535998, ECO:0000269|PubMed:15607730}.
CC -!- MISCELLANEOUS: Transport is inhibited by thiosulfate, phosphate,
CC molybdate, selenate and tungstate. Not inhibited by oxalate, citrate,
CC succinate, phenol red or 4,4'-diisothiocyanostilbene-2,2'-disulfonic
CC acid (DIDS).
CC -!- SIMILARITY: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family.
CC NADC subfamily. {ECO:0000305}.
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DR EMBL; AF169301; AAF05907.1; -; mRNA.
DR EMBL; AC091736; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH236950; EAL24058.1; -; Genomic_DNA.
DR EMBL; CH471070; EAW83858.1; -; Genomic_DNA.
DR EMBL; BC030689; AAH30689.1; -; mRNA.
DR CCDS; CCDS5840.1; -.
DR RefSeq; NP_001305121.1; NM_001318192.1.
DR RefSeq; NP_036582.2; NM_012450.3.
DR AlphaFoldDB; Q9UKG4; -.
DR SMR; Q9UKG4; -.
DR BioGRID; 117650; 28.
DR IntAct; Q9UKG4; 25.
DR STRING; 9606.ENSP00000297282; -.
DR TCDB; 2.A.47.1.14; the divalent anion:na(+) symporter (dass) family.
DR iPTMnet; Q9UKG4; -.
DR PhosphoSitePlus; Q9UKG4; -.
DR BioMuta; SLC13A4; -.
DR DMDM; 221222500; -.
DR EPD; Q9UKG4; -.
DR MassIVE; Q9UKG4; -.
DR PaxDb; Q9UKG4; -.
DR PeptideAtlas; Q9UKG4; -.
DR PRIDE; Q9UKG4; -.
DR ProteomicsDB; 84786; -.
DR Antibodypedia; 46129; 92 antibodies from 18 providers.
DR DNASU; 26266; -.
DR Ensembl; ENST00000354042.8; ENSP00000297282.5; ENSG00000164707.16.
DR GeneID; 26266; -.
DR KEGG; hsa:26266; -.
DR UCSC; uc003vta.4; human.
DR CTD; 26266; -.
DR DisGeNET; 26266; -.
DR GeneCards; SLC13A4; -.
DR HGNC; HGNC:15827; SLC13A4.
DR HPA; ENSG00000164707; Tissue enriched (choroid).
DR MIM; 604309; gene.
DR neXtProt; NX_Q9UKG4; -.
DR OpenTargets; ENSG00000164707; -.
DR PharmGKB; PA38045; -.
DR VEuPathDB; HostDB:ENSG00000164707; -.
DR eggNOG; KOG1281; Eukaryota.
DR GeneTree; ENSGT01030000234550; -.
DR HOGENOM; CLU_005170_9_1_1; -.
DR InParanoid; Q9UKG4; -.
DR OMA; ASKHIEW; -.
DR OrthoDB; 389981at2759; -.
DR PhylomeDB; Q9UKG4; -.
DR TreeFam; TF312913; -.
DR PathwayCommons; Q9UKG4; -.
DR Reactome; R-HSA-433137; Sodium-coupled sulphate, di- and tri-carboxylate transporters.
DR SignaLink; Q9UKG4; -.
DR BioGRID-ORCS; 26266; 15 hits in 1062 CRISPR screens.
DR ChiTaRS; SLC13A4; human.
DR GenomeRNAi; 26266; -.
DR Pharos; Q9UKG4; Tbio.
DR PRO; PR:Q9UKG4; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q9UKG4; protein.
DR Bgee; ENSG00000164707; Expressed in choroid plexus epithelium and 119 other tissues.
DR ExpressionAtlas; Q9UKG4; baseline and differential.
DR Genevisible; Q9UKG4; HS.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0015382; F:sodium:sulfate symporter activity; TAS:Reactome.
DR GO; GO:0098656; P:anion transmembrane transport; IBA:GO_Central.
DR GO; GO:0008272; P:sulfate transport; TAS:ProtInc.
DR InterPro; IPR001898; SLC13A/DASS.
DR Pfam; PF00939; Na_sulph_symp; 1.
PE 1: Evidence at protein level;
KW Ion transport; Membrane; Reference proteome; Sodium; Sodium transport;
KW Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..626
FT /note="Solute carrier family 13 member 4"
FT /id="PRO_0000172495"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 372..392
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 414..434
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 466..486
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 499..519
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 543..563
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 590..610
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 217..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 451
FT /note="P -> S (in dbSNP:rs36004833)"
FT /id="VAR_057193"
FT CONFLICT 198
FT /note="E -> DR (in Ref. 1; AAF05907)"
FT /evidence="ECO:0000305"
FT CONFLICT 245
FT /note="P -> R (in Ref. 5; AAH30689)"
FT /evidence="ECO:0000305"
FT CONFLICT 539
FT /note="L -> M (in Ref. 1; AAF05907)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 626 AA; 69358 MW; D84A18376DFAFA2B CRC64;
MGLLQGLLRV RKLLLVVCVP LLLLPLPVLH PSSEASCAYV LIVTAVYWVS EAVPLGAAAL
VPAFLYPFFG VLRSNEVAAE YFKNTTLLLV GVICVAAAVE KWNLHKRIAL RMVLMAGAKP
GMLLLCFMCC TTLLSMWLSN TSTTAMVMPI VEAVLQELVS AEDEQLVAGN SNTEEAEPIS
LDVKNSQPSL ELIFVNEESN ADLTTLMHNE NLNGVPSITN PIKTANQHQG KKQHPSQEKP
QVLTPSPRKQ KLNRKYRSHH DQMICKCLSL SISYSATIGG LTTIIGTSTS LIFLEHFNNQ
YPAAEVVNFG TWFLFSFPIS LIMLVVSWFW MHWLFLGCNF KETCSLSKKK KTKREQLSEK
RIQEEYEKLG DISYPEMVTG FFFILMTVLW FTREPGFVPG WDSFFEKKGY RTDATVSVFL
GFLLFLIPAK KPCFGKKNDG ENQEHSLGTE PIITWKDFQK TMPWEIVILV GGGYALASGS
KSSGLSTWIG NQMLSLSSLP PWAVTLLACI LVSIVTEFVS NPATITIFLP ILCSLSETLH
INPLYTLIPV TMCISFAVML PVGNPPNAIV FSYGHCQIKD MVKAGLGVNV IGLVIVMVAI
NTWGVSLFHL DTYPAWARVS NITDQA
