ABCGE_DICDI
ID ABCGE_DICDI Reviewed; 1439 AA.
AC Q55DR1; Q8T679;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=ABC transporter G family member 14;
DE AltName: Full=ABC transporter ABCG.14;
GN Name=abcG14; ORFNames=DDB_G0269210;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
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DR EMBL; AF482392; AAL91499.1; -; Genomic_DNA.
DR EMBL; AAFI02000005; EAL71955.1; -; Genomic_DNA.
DR RefSeq; XP_646070.1; XM_640978.1.
DR AlphaFoldDB; Q55DR1; -.
DR SMR; Q55DR1; -.
DR PaxDb; Q55DR1; -.
DR EnsemblProtists; EAL71955; EAL71955; DDB_G0269210.
DR GeneID; 8617019; -.
DR KEGG; ddi:DDB_G0269210; -.
DR dictyBase; DDB_G0269210; abcG14.
DR eggNOG; KOG0065; Eukaryota.
DR HOGENOM; CLU_000604_35_0_1; -.
DR InParanoid; Q55DR1; -.
DR OMA; VHGVIKP; -.
DR PhylomeDB; Q55DR1; -.
DR PRO; PR:Q55DR1; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IGC:dictyBase.
DR GO; GO:0031152; P:aggregation involved in sorocarp development; IBA:GO_Central.
DR GO; GO:0031288; P:sorocarp morphogenesis; IBA:GO_Central.
DR CDD; cd03233; ABCG_PDR_domain1; 1.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR029481; ABC_trans_N.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034001; ABCG_PDR_1.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010929; PDR_CDR_ABC.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF14510; ABC_trans_N; 1.
DR Pfam; PF06422; PDR_CDR; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1439
FT /note="ABC transporter G family member 14"
FT /id="PRO_0000391400"
FT TRANSMEM 479..499
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 516..536
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 564..584
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 589..609
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 614..634
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 734..754
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1144..1164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1175..1195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1217..1237
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1256..1276
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1283..1303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1413..1433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 117..370
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 475..700
FT /note="ABC transmembrane type-2 1"
FT DOMAIN 805..1049
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1141..1366
FT /note="ABC transmembrane type-2 2"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 841..848
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CONFLICT 1267
FT /note="F -> V (in Ref. 1; AAL91499)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1439 AA; 164076 MW; 4AB7C3F92C6012DA CRC64;
MEENSNKFEQ ELKEIGQDRN QFPHISVEES LQEFDSFSNK IENESKQFGA QKDPESYMAG
GETEEDFKLR KYFENSERMH LENGGNEKKM GVSIRNLTVV GLGADASVIA DMSTPFFSIL
NFFKPSFWTK KTSTFDILHD VTTFCKDGEM VLVLGRPGAG CSTLLRVIAN QTASYVSVKG
DVRYGGIPSK EFERYRAESI YTPEEDSHHP TLTVRETLDF ALKCKTPGNR LPDETKRSFR
EKVFNLLLSM FGIVHQADTI VGNEYVRGLS GGERKRLTIT EAMVSSASIT CWDCSTRGLD
AASAFDYAKS IRIMSDTLHK TTIASFYQAS DSIYNVFDKV CVLEKGRCIY FGPVGMAKQY
FMSLGFDCEP RKSTPDFLTG VTNPQERIIK KGFEGRTPET SADFEAAWKN SDIYRDQLQE
QKEYEELIER TQPKVAFVQE VKDENSKTNF KKSQYTTSFI TQVVALTKRN FQLILNDKFG
LFTKYLSVLI QAFVYSSVFY NMASDINGLF TRGGAILSAV IFNAFLSVGE MSMTFIGRRV
LQKHKSYALY RPSALHIAQV VNDIPFTLLQ VFLFSIIAYF MFGLEYDGGK FFIFSFTLVG
ASLACTALFR CFGYLCPSMY IAQNISNVFI IFMLTYSGYT VPIPKMHPWF SWFRHINIFT
YAFKAIMANE FEGKEFNCLE SAIPYGPAYQ GSEFDAYRIC PLGGIEQGSL YFKGEFYMDK
TLRFKEGEMS QNVIIVYCWW IFFVICNMLA MEYIDHTSGG YTHKVYKKGK APKMNDVEEE
KQQNAIVANA TNNMKDTLHM DGGIFTWQNI RYTVKVPGGE RLLLNNIEGW IKPGQMTALM
GSSGAGKTTL LDVLAKRKTL GVVEGDSHLN GRELEIDFER ITGYVEQMDV HNPGLTVREA
LRFSAKLRQE PEVSLEEKFK YVEHVLEMME MKHLGDALIG TLETGVGISV EERKRLTIGV
ELVAKPQILF LDEPTSGLDA QSSYNIIKFI RKLADAGMPL VCTIHQPSSV LFEHFDRILL
LAKGGKTVYF GDIGEKSKTL TSYFERHGVR PCTESENPAE YILEATGAGV HGKSDVNWPE
TWKQSPELAD ISRELAALKE QGAQQYKIRS DGPAREFSQS TWYQTKEVYK RLNLIWWRDP
YYTYGSFVQS ALCGLIIGFT FWNLQGSSSD MNQRIFFIFE ALMLGILLIF VVMPQLISQR
EYFKRDFASK FYSWFPFAIS IVVVELPFIV ISGTIFFFCS FWTAGLDKTS DSEQTFYFWF
IFVIFLFFCV SFGQAVAAVC INMFFAMTLI PLLIVFLFLF SGVMTPPSSI PTFWRGWVYH
LNPCRYFMEG IVTNILKTVD VKCSYEDMIT FTFPKSYNTC QNYTSAFQSY GPSGYVESSI
LNGEPACSYC IYKNGEQYYK TLGWSDDNRW RNVGIIICFF VFNILMVILF VYLTRKGSR
