S14L3_HUMAN
ID S14L3_HUMAN Reviewed; 400 AA.
AC Q9UDX4; E7EN74; E9PE57; Q495V8; Q495W0; Q495W1;
DT 28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=SEC14-like protein 3;
DE AltName: Full=Tocopherol-associated protein 2;
GN Name=SEC14L3; Synonyms=TAP2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=12757856; DOI=10.1016/s0891-5849(03)00173-4;
RA Kempna P., Zingg J.-M., Ricciarelli R., Hierl M., Saxena S., Azzi A.;
RT "Cloning of novel human SEC14p-like proteins: ligand binding and functional
RT properties.";
RL Free Radic. Biol. Med. 34:1458-1472(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS
RP THR-103 AND GLU-335.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable hydrophobic ligand-binding protein; may play a role
CC in the transport of hydrophobic ligands like tocopherol, squalene and
CC phospholipids.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9UDX4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UDX4-2; Sequence=VSP_045554;
CC Name=3;
CC IsoId=Q9UDX4-3; Sequence=VSP_045553;
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DR EMBL; AY158086; AAO21870.1; -; mRNA.
DR EMBL; AC004832; AAF19258.1; -; Genomic_DNA.
DR EMBL; BC101001; AAI01002.1; -; mRNA.
DR EMBL; BC101002; AAI01003.1; -; mRNA.
DR EMBL; BC101004; AAI01005.1; -; mRNA.
DR CCDS; CCDS13877.1; -. [Q9UDX4-1]
DR CCDS; CCDS58800.1; -. [Q9UDX4-3]
DR CCDS; CCDS58801.1; -. [Q9UDX4-2]
DR RefSeq; NP_001244307.1; NM_001257378.1. [Q9UDX4-3]
DR RefSeq; NP_001244308.1; NM_001257379.1. [Q9UDX4-2]
DR RefSeq; NP_001244311.1; NM_001257382.1. [Q9UDX4-2]
DR RefSeq; NP_777635.1; NM_174975.4. [Q9UDX4-1]
DR PDB; 4UYB; X-ray; 1.50 A; A=1-400.
DR PDBsum; 4UYB; -.
DR AlphaFoldDB; Q9UDX4; -.
DR SMR; Q9UDX4; -.
DR BioGRID; 129297; 6.
DR IntAct; Q9UDX4; 3.
DR STRING; 9606.ENSP00000215812; -.
DR DrugBank; DB14003; alpha-Tocopherol acetate.
DR DrugBank; DB14001; alpha-Tocopherol succinate.
DR DrugBank; DB14002; D-alpha-Tocopherol acetate.
DR DrugBank; DB11635; Tocofersolan.
DR DrugBank; DB11251; Tocopherol.
DR DrugBank; DB00163; Vitamin E.
DR iPTMnet; Q9UDX4; -.
DR PhosphoSitePlus; Q9UDX4; -.
DR BioMuta; SEC14L3; -.
DR DMDM; 29428056; -.
DR EPD; Q9UDX4; -.
DR jPOST; Q9UDX4; -.
DR MassIVE; Q9UDX4; -.
DR MaxQB; Q9UDX4; -.
DR PaxDb; Q9UDX4; -.
DR PeptideAtlas; Q9UDX4; -.
DR PRIDE; Q9UDX4; -.
DR Antibodypedia; 59073; 47 antibodies from 11 providers.
DR DNASU; 266629; -.
DR Ensembl; ENST00000215812.9; ENSP00000215812.5; ENSG00000100012.12. [Q9UDX4-1]
DR Ensembl; ENST00000401751.5; ENSP00000383896.1; ENSG00000100012.12. [Q9UDX4-2]
DR Ensembl; ENST00000402286.5; ENSP00000385004.1; ENSG00000100012.12. [Q9UDX4-3]
DR Ensembl; ENST00000540910.5; ENSP00000439752.1; ENSG00000100012.12. [Q9UDX4-3]
DR GeneID; 266629; -.
DR KEGG; hsa:266629; -.
DR MANE-Select; ENST00000215812.9; ENSP00000215812.5; NM_174975.5; NP_777635.1.
DR UCSC; uc003ahy.4; human. [Q9UDX4-1]
DR CTD; 266629; -.
DR DisGeNET; 266629; -.
DR GeneCards; SEC14L3; -.
DR HGNC; HGNC:18655; SEC14L3.
DR HPA; ENSG00000100012; Tissue enhanced (bone marrow, liver, retina).
DR MIM; 612824; gene.
DR neXtProt; NX_Q9UDX4; -.
DR OpenTargets; ENSG00000100012; -.
DR PharmGKB; PA134960743; -.
DR VEuPathDB; HostDB:ENSG00000100012; -.
DR eggNOG; KOG1471; Eukaryota.
DR GeneTree; ENSGT00940000162077; -.
DR HOGENOM; CLU_014001_2_1_1; -.
DR InParanoid; Q9UDX4; -.
DR OMA; VYIEQMG; -.
DR PhylomeDB; Q9UDX4; -.
DR TreeFam; TF313988; -.
DR PathwayCommons; Q9UDX4; -.
DR SignaLink; Q9UDX4; -.
DR BioGRID-ORCS; 266629; 10 hits in 1066 CRISPR screens.
DR GenomeRNAi; 266629; -.
DR Pharos; Q9UDX4; Tbio.
DR PRO; PR:Q9UDX4; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q9UDX4; protein.
DR Bgee; ENSG00000100012; Expressed in olfactory segment of nasal mucosa and 36 other tissues.
DR ExpressionAtlas; Q9UDX4; baseline and differential.
DR Genevisible; Q9UDX4; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; -; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011074; CRAL/TRIO_N_dom.
DR InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR InterPro; IPR009038; GOLD_dom.
DR InterPro; IPR036598; GOLD_dom_sf.
DR Pfam; PF00650; CRAL_TRIO; 1.
DR SMART; SM01100; CRAL_TRIO_N; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF101576; SSF101576; 1.
DR SUPFAM; SSF46938; SSF46938; 1.
DR SUPFAM; SSF52087; SSF52087; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Lipid-binding; Reference proteome;
KW Transport.
FT CHAIN 1..400
FT /note="SEC14-like protein 3"
FT /id="PRO_0000210758"
FT DOMAIN 76..249
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT DOMAIN 275..383
FT /note="GOLD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
FT VAR_SEQ 1..78
FT /note="MSGRVGDLSPKQAETLAKFRENVQDVLPALPNPDDYFLLRWLRARNFDLQKS
FT EALLRKYMEFRKTMDIDHILDWQPPE -> M (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_045553"
FT VAR_SEQ 1..59
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_045554"
FT VARIANT 103
FT /note="I -> T (in dbSNP:rs4820853)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_024627"
FT VARIANT 214
FT /note="R -> H (in dbSNP:rs2269961)"
FT /id="VAR_024628"
FT VARIANT 335
FT /note="D -> E (in dbSNP:rs2240345)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_022097"
FT VARIANT 364
FT /note="R -> C (in dbSNP:rs35764129)"
FT /id="VAR_061787"
FT HELIX 10..23
FT /evidence="ECO:0007829|PDB:4UYB"
FT TURN 24..26
FT /evidence="ECO:0007829|PDB:4UYB"
FT HELIX 27..29
FT /evidence="ECO:0007829|PDB:4UYB"
FT HELIX 35..44
FT /evidence="ECO:0007829|PDB:4UYB"
FT TURN 45..47
FT /evidence="ECO:0007829|PDB:4UYB"
FT HELIX 49..65
FT /evidence="ECO:0007829|PDB:4UYB"
FT HELIX 68..73
FT /evidence="ECO:0007829|PDB:4UYB"
FT HELIX 78..83
FT /evidence="ECO:0007829|PDB:4UYB"
FT STRAND 86..91
FT /evidence="ECO:0007829|PDB:4UYB"
FT STRAND 97..102
FT /evidence="ECO:0007829|PDB:4UYB"
FT HELIX 108..112
FT /evidence="ECO:0007829|PDB:4UYB"
FT HELIX 117..142
FT /evidence="ECO:0007829|PDB:4UYB"
FT STRAND 149..154
FT /evidence="ECO:0007829|PDB:4UYB"
FT HELIX 160..163
FT /evidence="ECO:0007829|PDB:4UYB"
FT HELIX 165..181
FT /evidence="ECO:0007829|PDB:4UYB"
FT STRAND 186..193
FT /evidence="ECO:0007829|PDB:4UYB"
FT HELIX 198..205
FT /evidence="ECO:0007829|PDB:4UYB"
FT HELIX 206..208
FT /evidence="ECO:0007829|PDB:4UYB"
FT HELIX 211..215
FT /evidence="ECO:0007829|PDB:4UYB"
FT STRAND 217..219
FT /evidence="ECO:0007829|PDB:4UYB"
FT HELIX 224..231
FT /evidence="ECO:0007829|PDB:4UYB"
FT HELIX 234..236
FT /evidence="ECO:0007829|PDB:4UYB"
FT HELIX 239..241
FT /evidence="ECO:0007829|PDB:4UYB"
FT STRAND 243..245
FT /evidence="ECO:0007829|PDB:4UYB"
FT TURN 255..257
FT /evidence="ECO:0007829|PDB:4UYB"
FT HELIX 266..268
FT /evidence="ECO:0007829|PDB:4UYB"
FT STRAND 279..285
FT /evidence="ECO:0007829|PDB:4UYB"
FT STRAND 289..296
FT /evidence="ECO:0007829|PDB:4UYB"
FT STRAND 302..308
FT /evidence="ECO:0007829|PDB:4UYB"
FT STRAND 310..312
FT /evidence="ECO:0007829|PDB:4UYB"
FT STRAND 314..324
FT /evidence="ECO:0007829|PDB:4UYB"
FT HELIX 330..332
FT /evidence="ECO:0007829|PDB:4UYB"
FT STRAND 333..342
FT /evidence="ECO:0007829|PDB:4UYB"
FT STRAND 345..347
FT /evidence="ECO:0007829|PDB:4UYB"
FT STRAND 349..354
FT /evidence="ECO:0007829|PDB:4UYB"
FT STRAND 359..366
FT /evidence="ECO:0007829|PDB:4UYB"
FT STRAND 371..384
FT /evidence="ECO:0007829|PDB:4UYB"
FT HELIX 388..391
FT /evidence="ECO:0007829|PDB:4UYB"
FT HELIX 392..396
FT /evidence="ECO:0007829|PDB:4UYB"
SQ SEQUENCE 400 AA; 46048 MW; 07F880D25B66CC19 CRC64;
MSGRVGDLSP KQAETLAKFR ENVQDVLPAL PNPDDYFLLR WLRARNFDLQ KSEALLRKYM
EFRKTMDIDH ILDWQPPEVI QKYMPGGLCG YDRDGCPVWY DIIGPLDPKG LLFSVTKQDL
LKTKMRDCER ILHECDLQTE RLGKKIETIV MIFDCEGLGL KHFWKPLVEV YQEFFGLLEE
NYPETLKFML IVKATKLFPV GYNLMKPFLS EDTRRKIIVL GNNWKEGLLK LISPEELPAQ
FGGTLTDPDG NPKCLTKINY GGEIPKSMYV RDQVKTQYEH SVQINRGSSH QVEYEILFPG
CVLRWQFSSD GADIGFGVFL KTKMGERQRA GEMTDVLPSQ RYNAHMVPED GNLTCSEAGV
YVLRFDNTYS FVHAKKVSFT VEVLLPDEGM QKYDKELTPV