ID   S14L3_RAT               Reviewed;         400 AA.
AC   Q9Z1J8;
DT   28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=SEC14-like protein 3;
DE   AltName: Full=45 kDa secretory protein;
DE            Short=rsec45;
GN   Name=Sec14l3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 5-11; 22-43; 52-58;
RP   174-184; 217-225; 231-253; 258-266; 269-279 AND 383-396.
RC   TISSUE=Olfactory epithelium;
RX   PubMed=10350070; DOI=10.1016/s0014-5793(99)00470-6;
RA   Merkulova M.I., Andreeva S.G., Shuvaeva T.M., Novoselov S.V.,
RA   Peshenko I.V., Bystrova M.F., Novoselov V.I., Fesenko E.E., Lipkin V.M.;
RT   "A novel 45 kDa secretory protein from rat olfactory epithelium: primary
RT   structure and localisation.";
RL   FEBS Lett. 450:126-130(1999).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-223, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: Probable hydrophobic ligand-binding protein; may play a role
CC       in the transport of hydrophobic ligands like tocopherol, squalene and
CC       phospholipids.
CC   -!- TISSUE SPECIFICITY: Detected in a layer of supportive cells in
CC       olfactory epithelium, in the apical region of the trachea and in the
CC       surface layer of ciliated bronchial epithelium in the lung.
CC   -!- PTM: The N-terminus seems to be blocked.
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DR   EMBL; AJ132352; CAA10644.1; -; mRNA.
DR   AlphaFoldDB; Q9Z1J8; -.
DR   STRING; 10116.ENSRNOP00000006116; -.
DR   iPTMnet; Q9Z1J8; -.
DR   PhosphoSitePlus; Q9Z1J8; -.
DR   jPOST; Q9Z1J8; -.
DR   PaxDb; Q9Z1J8; -.
DR   PRIDE; Q9Z1J8; -.
DR   UCSC; RGD:620812; rat.
DR   RGD; 620812; Sec14l3.
DR   VEuPathDB; HostDB:ENSRNOG00000004555; -.
DR   eggNOG; KOG1471; Eukaryota.
DR   HOGENOM; CLU_014001_2_1_1; -.
DR   InParanoid; Q9Z1J8; -.
DR   PRO; PR:Q9Z1J8; -.
DR   Proteomes; UP000002494; Chromosome 14.
DR   Bgee; ENSRNOG00000004555; Expressed in lung and 13 other tissues.
DR   ExpressionAtlas; Q9Z1J8; baseline and differential.
DR   Genevisible; Q9Z1J8; RN.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 3.40.525.10; -; 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR011074; CRAL/TRIO_N_dom.
DR   InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR   InterPro; IPR009038; GOLD_dom.
DR   InterPro; IPR036598; GOLD_dom_sf.
DR   Pfam; PF00650; CRAL_TRIO; 1.
DR   SMART; SM01100; CRAL_TRIO_N; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF101576; SSF101576; 1.
DR   SUPFAM; SSF46938; SSF46938; 1.
DR   SUPFAM; SSF52087; SSF52087; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS50866; GOLD; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Lipid-binding; Phosphoprotein;
KW   Reference proteome; Transport.
FT   CHAIN           1..400
FT                   /note="SEC14-like protein 3"
FT                   /id="PRO_0000210759"
FT   DOMAIN          76..249
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT   DOMAIN          275..383
FT                   /note="GOLD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
FT   MOD_RES         223
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   400 AA;  46027 MW;  548A72DDA9B4FC26 CRC64;
     MSGRVGDLSP KQAETLAKFR ENVQDVLPAL PNPDDYFLLR WLRARNFDLQ KSEAMLRKYM
     EFRKTMDIDH ILDWQPPEVI QKYMPGGLCG YDRDGCPVWY DIIGPLDPKG LLFSVTKQDL
     LKTKMRDCER ILHECDLQTE RLGRKIETIV MIFDCEGLGL KHFWKPLVEV YQEFFGLLEE
     NYPETLKFML IVKATKLFPV GYNLMKPFLS EDTRRKIVVL GNSWKEGLLK LISPEELPAH
     FGGTLTDPDG NPKCLTKINY GGEIPKSMYV RDQVKTQYEH SVQISRGSSH QVEYEILFPG
     CVLRWQFSSD GADIGFGVFL KTKMGERQKA GEMTEVLTSQ RYNAHMVPED GSLTCTEAGV
     YVLRFDNTYS FVHAKKVSFT VEVLLPDEGM QKYDEELTPI